The Role of NF-κB in Myocardial Ischemia/Reperfusion Injury

Abstract

Acute myocardial infarction (AMI ) is a threat to human life and physical health all over the world . Timely reperfusion is very important to limit infarct size and protect ischemic myocardium . Unfortunately, it also caused more severer myocardial damage, which is called "myocardial ischemia/reperfusion injury (MIRI )''. There is no effective clinical treatment for it . Over the past two decades, biological studies of NF-κB have improved the understanding of MIRI. Nuclear Factor-κB (NF-κB ) is a major transcription factor associated with cardiovascular health and disease. It is involved in the release of pro-inflammatory factors and apoptosis of cardiomyocytes. Recent studies have shown that inhibition of NF-κB plays a protective role in acute hypoxia and reperfusion injury . Here we review the molecular regulation of NF-κB in MIRI , better understanding of NF-κB signaling mechanisms related to inflammation and crosstalk with endogenous small molecules . We hope this review will aid in improving therapeutic approaches to clinical diagnosing . This review provides evidence for the role of NF-κB in MIRI and supports its use as a therapeutic target .

A plasma proteomic approach in patients with heart failure after acute myocardial infarction: insights into the pathogenesis and progression of the disease

“…NF-κB is central to the immune response to infection ( 35 ). Incorrect regulation of NF-κB is also associated with cancer ( 36 ), inflammation ( 37 ), autoimmune ( 38 ) diseases, septic shock ( 39 ), viral infection ( 40 ), differentiation ( 41 ), apoptosis, ferroptosis ( 42 ) and cardiovascular diseases ( 43 ). NF-κB has been shown to be involved in the process of HF after ischaemia/re-perfusion ( 44 ).…”

Bioinformatics analysis of potential common pathogenic mechanisms for systemic lupus erythematosus and acute myocardial infarction

“…59 Recent studies have shown that the inhibition of NF-κB can protect against reperfusion injury. 60 Specificity protein (Sp) is composed of Sp1, Sp2, and Sp3, with Sp1 increasingly implicated in the development of atherosclerosis, including inflammation, lipid metabolism, plaque stability, and endothelial dysfunction. 61 DNA binding analyses have demonstrated that SP1 binds to the CREM promoter, leading to increased CREM expression that promotes the development of SLE.…”

Metabolomics analysis in rat hearts with ischemia/reperfusion injury after diazoxide postconditioning

“…Recently, studies have proven that both the NF-κB signalling pathway and SIRT1 are associated with MIRI ( Xu et al, 2021 ; Aghamohammad et al, 2022 ; Xiao et al, 2022 ). The cardiovascular protective effect of the NF-κB signalling pathway is related to regulating the inflammatory response ( Dong et al, 2022 ). SIRT1, an NAD + -dependent deacetylase, plays a significant role in antioxidative stress activity ( Zhang et al, 2017 ).…”