The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology

Morash, Margaret; Mitchell, Howard E.; Beltran, Himisha; Elemento, Olivier; Pathak, Jyotishman

doi:10.20944/preprints201807.0071.v1

Cited by 16 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, at the 2023 ASCO meeting, results from a phase I trial using gavocabtagene autoleucel, an autologous genetically engineered anti-mesothelin T cell receptor fusion construct cell therapy, were presented [112] . This trial focused on patients with refractory mesothelioma and other mesothelin-expressing solid tumors, including BTC.…”

Section: Adoptive Immunotherapymentioning

confidence: 99%

Challenges and opportunities for treating intrahepatic cholangiocarcinoma: targeted therapy

Gim,

Badri

2023

Hepatoma Res

View full text Add to dashboard Cite

Over the last two decades, substantial progress has been made in the scope of molecular targeted therapy, leading to transformative advancements in the treatment of various malignancies, including biliary tract cancer (BTC). BTC represents a heterogeneous group of aggressive tumors with historically poor prognoses. However, recent discoveries of novel molecular alterations in BTC have provided new avenues for targeted therapeutic interventions, exemplified by the approval of pemigatinib, specifically designed for FGFR2 gene fusions or rearrangements in advanced BTC. Furthermore, subsequent regulatory approvals and ongoing clinical trials focusing on specific gene mutations have considerably expanded the array of treatment options available, augmenting the potential for personalized treatment strategies. In light of these developments, this review aims to furnish a comprehensive and up-to-date account of the molecular characteristics and potential targeted therapies in BTC. By presenting insights into novel therapeutic approaches and outlining prospective directions for translational and clinical investigations, this review seeks to contribute to the ongoing progress and optimization of therapeutic approaches in managing BTC.

show abstract

Section: Adoptive Immunotherapymentioning

confidence: 99%

Challenges and opportunities for treating intrahepatic cholangiocarcinoma: targeted therapy

Gim,

Badri

2023

Hepatoma Res

View full text Add to dashboard Cite

show abstract

Filming space-time changes of gene expression with expressyouRcell

Paganin¹,

Tebaldi

Lauria³

et al. 2022

Preprint

View full text Add to dashboard Cite

The last decade has witnessed massive advancements in high-throughput techniques capable of producing quantifications of transcript and protein levels across time and space, and at high resolution. Yet, the large volume of big data available and the complexity of experimental designs hamper an easy understanding and effective communication of the results. Here we present expressyouRcell, a unique and easy-to-use R package to map the multi-dimensional variations of transcript and protein levels in cell-pictographs. These variations are outcomes of differential and gene set enrichment analysis across space and time. Our tool directly associates these results with up to twenty specific cellular compartments, visualising them as pictographic representations of four different cellular thematic maps. expressyouRcell visually reduces the complexity of displaying gene expression and protein level changes across multiple time-points by generating dynamic representations of cellular pictographs. We applied expressyouRcell to six datasets, demonstrating its flexibility and usability in the visualization of simple and highly effective static and dynamic representations of time course variations in gene expression. Our approach complements classical plot-based methods for visualization and exploitation of biological data, improving the standard quantitative interpretation and communication of relevant results.

show abstract

Exploiting Cancer’s Tactics to Make Cancer a Manageable Chronic Disease

Afrasiabi

Linskey

Zhou

2020

Cancers

View full text Add to dashboard Cite

The history of modern oncology started around eighty years ago with the introduction of cytotoxic agents such as nitrogen mustard into the clinic, followed by multi-agent chemotherapy protocols. Early success in radiation therapy in Hodgkin lymphoma gave birth to the introduction of radiation therapy into different cancer treatment protocols. Along with better understanding of cancer biology, we developed drugs targeting cancer-related cellular and genetic aberrancies. Discovery of the crucial role of vasculature in maintenance, survival, and growth of a tumor opened the way to the development of anti-angiogenic agents. A better understanding of T-cell regulatory pathways advanced immunotherapy. Awareness of stem-like cancer cells and their role in cancer metastasis and local recurrence led to the development of drugs targeting them. At the same time, sequential and rapidly accelerating advances in imaging and surgical technology have markedly increased our ability to safely remove ≥90% of tumor cells. While we have advanced our ability to kill cells from multiple directions, we have still failed to stop most types of cancer from recurring. Here we analyze the tactics employed in cancer evolution; namely, chromosomal instability (CIN), intra-tumoral heterogeneity (ITH), and cancer-specific metabolism. These tactics govern the resistance to current cancer therapeutics. It is time to focus on maximally delaying the time to recurrence, with drugs that target these fundamental tactics of cancer evolution. Understanding the control of CIN and the optimal state of ITH as the most important tactics in cancer evolution could facilitate the development of improved cancer therapeutic strategies designed to transform cancer into a manageable chronic disease.

show abstract

The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology

Cited by 16 publications

References 21 publications

Challenges and opportunities for treating intrahepatic cholangiocarcinoma: targeted therapy

Challenges and opportunities for treating intrahepatic cholangiocarcinoma: targeted therapy

Filming space-time changes of gene expression with expressyouRcell

Exploiting Cancer’s Tactics to Make Cancer a Manageable Chronic Disease

Contact Info

Product

Resources

About