The Role of New Immunosuppressive Drugs in Nonmelanoma Skin Cancer in Renal Transplant Recipients

Bernat-García, Josefa; Suárez-Varela, M. Morales; Vilata-Corell, J.J.; Marquina-Vila, A.; Pallardó, Luís; Crespo, J.F.

doi:10.1016/j.adengl.2014.06.005

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Our results showed that 23% of patients diagnosed with NMSC were within the first 5 years after transplantation, while 51.3% had been transplanted for over 10 years. Advanced age has been identified in the literature as a risk factor for NMSC development in RTx [19,20]. We found that the average age of RTxs at the time of NMSC diagnosis was significantly higher compared to RTx without this type of cancer, increasing the risk of developing this tumor by more than 5 times, consistent with other research in individuals with the same clinical condition [14,20,21].…”

Section: Discussionsupporting

confidence: 90%

“…Advanced age has been identified in the literature as a risk factor for NMSC development in RTx [19,20]. We found that the average age of RTxs at the time of NMSC diagnosis was significantly higher compared to RTx without this type of cancer, increasing the risk of developing this tumor by more than 5 times, consistent with other research in individuals with the same clinical condition [14,20,21]. Furthermore, according to information provided by the Brazilian National Cancer Institute, the highest incidence 10 of NMSC occurs at the age of 40.…”

Section: Discussionmentioning

confidence: 99%

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Routine outpatient dermatological evaluation of kidney transplant recipients using dermatoscopy as an additional tool: a preliminary analysis

Caldas,

Abbud-Filho

et al. 2023

Preprint

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Introduction. Non-melanoma skin cancer (NMSC) is the most common malignancy following renal transplantation and leads to significant years of potential life lost. Dermatoscopy use in the routine clinical setting has shown promise in increasing the diagnosis of NMSC. Objectives. 1) To assess the prevalence of NMSC in renal transplant recipients (RTx) using the dermatoscopy (DC); 2) to identify associated risk factors; 3) to compare the accuracy of dermatoscopy with histopathological results. Methods. A prospective study was conducted from January 2022 to January 2023 and 100 RTx from the outpatient clinic were randomly referred for dermatological examination and then divided into two groups: with NMSC (NMSC; n=39) and without NMSC (non-NMSC; n=61). RTx variables related to habits, tumor characteristics, and transplantation were analyzed. Results: Clinical dermatological evaluation identified 23 squamous cell carcinoma (SCC) (59%) and 16 basal cell carcinoma (BCC) (41%). Factors associated with NMSC included: male gender (OR=2); age over 50 years (OR=5.4); occupational sun exposure (OR=2.5); recreational sun exposure (OR=4.9); actinic keratosis (OR=6.5); family history of NMSC (OR=7.6); and induction with thymoglobulin (OR=2.4). The accuracy rate between clinical diagnosis and dermatoscopy compared to the final histological result after biopsy was 81.25% for suspected NMSC cases. Conclusions: NMSC occurred in 39% of the evaluated RTx cases, with a family history and actinic keratosis being the main risk factors. Dermatoscopy diagnosed NMSC in 81%, and therefore, we suggest that this examination should be incorporated into routine evaluation.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Routine outpatient dermatological evaluation of kidney transplant recipients using dermatoscopy as an additional tool: a preliminary analysis

Caldas,

Abbud-Filho

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…However, as skin cancer incidence correlates with patient age and the duration of immunosuppression, it is expected that we will diagnose more SCCs as the post‐transplantation follow‐up time increases . Nevertheless, the higher number of removed BCCs is not a unique finding; in Swedish, Spanish, German, and Hungarian studies, more BCCs than SCCs were reported in OTRs, which contradicts the findings of earlier publications that OTRs tend to develop 4 times more SCCs than BCCs. A higher BCC to SCC ratio could result from a particular genetic background or more intermittent UV exposure in these patient populations.…”

Section: Discussionmentioning

confidence: 73%

Comparison of pre‐ and post‐transplant sun‐safe behavior of kidney transplant recipients: What is needed to improve?

Gellén

Papp

Janka

et al. 2018

Photoderm Photoimm Photomed

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“…Other risk factors related to posttransplant skin cancer include skin cancer prior to transplant, 8 living vs deceased donor, 21 history of malignant neo-plasm prior to transplant, 22,23 and age, 12,22,24 sex, 25,26 ethnicity, 27 geographic location, 28,29 and smoking. [30][31][32] Melanomaspecific risk factors include older age at transplantation, 24,33 skin type, 31 sun exposure burden, 32,34,35 and duration of immunosuppression. 36 Our analysis corroborates results from current literature.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Melanoma in Renal Transplant Recipients

Ascha

Tanenbaum

et al. 2017

JAMA Dermatol

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IMPORTANCE Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. OBJECTIVE To determine risk factors and characteristics of renal transplant recipients who develop melanoma. DESIGN, SETTING, AND PARTICIPANTSThis cohort study of a large national data registry used a cohort of renal transplant recipients from the United States Renal Data System (USRDS) database from the years 2004 through 2012. Differences in baseline characteristics between those who did and did not develop melanoma were examined, and a survival analysis was performed. Patients with renal transplants who received a diagnosis of melanoma according to any inpatient or outpatient claim associated with a billing code for melanoma were included. A history of pretransplant melanoma, previous kidney transplantation, or transplantation after 2012 or before 2004 were exclusion criteria. The data analysis was conducted from 2015 to 2016. EXPOSURE Receipt of a renal transplant. MAIN OUTCOMES AND MEASURES Incidence and risk factors for melanoma. RESULTS Of 105 174 patients (64 151 [60.7%] male; mean [SD] age, 49.6 [15.3] years) who received kidney transplants between 2004 and 2012, 488 (0.4%) had a record of melanoma after transplantation. Significant risk factors for developing melanoma vs not developing melanoma included older age among recipients (mean [SD] age, 60.5 [10.2] vs 49.7 [15.3] years; P < .001) and donors (42.6 [15.0] vs 39.2 [15.1] years; P < .001), male sex (71.5% vs 60.7%; P < .001), recipient (96.1% vs 66.5%; P < .001) and donor (92.4% vs 82.9%; P < .001) white race, less than 4 HLA mismatches (44.9% vs 37.1%; P = .001), living donors (44.7% vs 33.7%; P < .001), and sirolimus (22.3% vs 13.2%; P < .001) and cyclosporine (4.9% vs 3.2%; P = .04) therapy. Risk factors significant on survival analysis included older recipient age (hazard ratio [HR] per year, 1

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The Role of New Immunosuppressive Drugs in Nonmelanoma Skin Cancer in Renal Transplant Recipients

Cited by 6 publications

References 32 publications

Routine outpatient dermatological evaluation of kidney transplant recipients using dermatoscopy as an additional tool: a preliminary analysis

Routine outpatient dermatological evaluation of kidney transplant recipients using dermatoscopy as an additional tool: a preliminary analysis

Comparison of pre‐ and post‐transplant sun‐safe behavior of kidney transplant recipients: What is needed to improve?

Risk Factors for Melanoma in Renal Transplant Recipients

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