The role of neutrophil extracellular traps in cancer metastasis

Wang, William Yang; Zhang, Jiayang; Zheng, Nanan; Li, Li; Wang, Xiangdong; Zeng, Yiming

doi:10.1002/ctm2.126

Cited by 18 publications

(10 citation statements)

References 14 publications

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“…Neutrophil extracellular traps (NETs) are formed when activated neutrophils release their intracellular contents, including DNA, histones and granule components, into the surrounding tissue or circulation [ 290 ]. NET formation is dependent on autophagy and is mediated by citrullination of histones to allow for the unwinding and subsequent expulsion of DNA [ 291 ].…”

Section: The Delicate Balance Between Anti- and Pro-tumor Neutrophilsmentioning

confidence: 99%

“…MPO synergizes with NE in driving chromatin decondensation [ 272 ]. NET formation frequently occurs in cancer where it promotes tumor growth, metastasis and cancer-associated thrombosis [ 290 , 292 , 294 , 296 , 297 , 298 , 299 ]. The production of NETs might also lead to the release of factors that can encourage tumor growth and even metastasis [ 300 ].…”

Section: The Delicate Balance Between Anti- and Pro-tumor Neutrophilsmentioning

confidence: 99%

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Leveling Up the Controversial Role of Neutrophils in Cancer: When the Complexity Becomes Entangled

Sionov

2021

Cells

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Neutrophils are the most abundant immune cell in the circulation of human and act as gatekeepers to discard foreign elements that have entered the body. They are essential in initiating immune responses for eliminating invaders, such as microorganisms and alien particles, as well as to act as immune surveyors of cancer cells, especially during the initial stages of carcinogenesis and for eliminating single metastatic cells in the circulation and in the premetastatic organs. Since neutrophils can secrete a whole range of factors stored in their many granules as well as produce reactive oxygen and nitrogen species upon stimulation, neutrophils may directly or indirectly affect carcinogenesis in both the positive and negative directions. An intricate crosstalk between tumor cells, neutrophils, other immune cells and stromal cells in the microenvironment modulates neutrophil function resulting in both anti- and pro-tumor activities. Both the anti-tumor and pro-tumor activities require chemoattraction towards the tumor cells, neutrophil activation and ROS production. Divergence is seen in other neutrophil properties, including differential secretory repertoire and membrane receptor display. Many of the direct effects of neutrophils on tumor growth and metastases are dependent on tight neutrophil–tumor cell interactions. Among them, the neutrophil Mac-1 interaction with tumor ICAM-1 and the neutrophil L-selectin interaction with tumor-cell sialomucins were found to be involved in the neutrophil-mediated capturing of circulating tumor cells resulting in increased metastatic seeding. On the other hand, the anti-tumor function of neutrophils was found to rely on the interaction between tumor-surface-expressed receptor for advanced glycation end products (RAGE) and Cathepsin G expressed on the neutrophil surface. Intriguingly, these two molecules are also involved in the promotion of tumor growth and metastases. RAGE is upregulated during early inflammation-induced carcinogenesis and was found to be important for sustaining tumor growth and homing at metastatic sites. Cathepsin G was found to be essential for neutrophil-supported lung colonization of cancer cells. These data level up the complexity of the dual role of neutrophils in cancer.

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Section: The Delicate Balance Between Anti- and Pro-tumor Neutrophilsmentioning

confidence: 99%

Section: The Delicate Balance Between Anti- and Pro-tumor Neutrophilsmentioning

confidence: 99%

Leveling Up the Controversial Role of Neutrophils in Cancer: When the Complexity Becomes Entangled

Sionov

2021

Cells

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“…Tumor cells can interact direct or indirectly with neutrophils to induce NET production. Intra-and inter-cellular molecular communications generate micro-environments that act as a premetastatic niche to recruit primary tumor cells and form multiple metastases [144,145]. Park et al, described the relationship between metastatic cancer and NET formation through the use of anti-G-CSF blocking antibodies, which reduce the ability of 4T1 cells to induce NETosis [146].…”

Section: Biomarkers Anaesthetic Technique and Cancermentioning

confidence: 99%

Breast Cancer and Anaesthesia: Genetic Influence

Ponferrada

Orriach

Ruiz

et al. 2021

IJMS

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Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction.

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Section: Neutrophil Extracellular Traps (Nets)mentioning

confidence: 99%