The role of neurotrophins in bipolar disorder

Scola, Gustavo; Andreazza, Ana Cristina

doi:10.1016/j.pnpbp.2014.08.013

Cited by 52 publications

(43 citation statements)

References 80 publications

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“…For instance, there is a phasic alteration in VEGF levels in BD, being usually high in maniac and depressive stages. It has also been noticed that lithium treatment apparently decreases VEGF expression in remissive patients (Scola & Andreazza, 2015). This may hint towards the role of VEGF in pharmacological effects of mood stabilizers such as lithium.…”

Section: Introductionmentioning

confidence: 98%

“…Further, IGF-1 might have a significant role in the pathogenesis of BD, since its gene is located on a BD-associated chromosomal region. Additionally, its peripheral levels seem to be decreased in BD patients and up-regulated in lithium responsive patients (Scola & Andreazza, 2015). It will be interesting to examine if alterations in IGF-1 levels in BD patients are a universal phenomenon, or differ based on patients’ manic, depressive or euthymic status at the time of blood withdrawal.…”

Section: Introductionmentioning

confidence: 99%

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Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Sharma

Silva

Soares

et al. 2016

Journal of Affective Disorders

116

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Rationale The neurotrophin hypothesis of major depressive disorder (MDD) postulates that this illness results from aberrant neurogenesis in brain regions that regulates emotion and memory. Notwithstanding this theory has primarily implicated BDNF in the neurobiology of MDD. Recent evidence suggests that other trophic factors namely GDNF, VEGF and IGF-1 may also be involved. Purpose The present review aimed to critically summarize evidence regarding changes in GDNF, IGF-1 and VEGF in individuals with MDD compared to healthy controls. In addition, we also evaluated the role of these mediators as potential treatment response biomarkers for MDD. Methods A comprehensive review of original studies studies measuring peripheral, central or mRNA levels of GDNF, IGF-1 or VEGF in patients with MDD was conducted. The PubMed/MEDLINE database was searched for peer-reviewed studies published in English through June 2nd, 2015. Results Most studies reported a reduction in peripheral GDNF and its mRNA levels in MDD patients versus controls. In contrast, IGF-1 levels in MDD patients compared to controls were discrepant across studies. Finally, most studies reported high peripheral VEGF levels and mRNA expression in MDD patients compared to healthy controls. Conclusions GDNF, IGF-1 and VEGF levels and their mRNA expression appear to be differentially altered in MDD patients compared to healthy individuals, indicating that these molecules might play an important role in the pathophysiology of depression and antidepressant action of therapeutic interventions.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Sharma

Silva

Soares

et al. 2016

Journal of Affective Disorders

116

View full text Add to dashboard Cite

show abstract

“…The underlying patho-etiology of BD remains incompletely elucidated but may involve the complex interaction of genetic and environmental factors (Nurnberger et al, 2014;Uher, 2014). Furthermore, several lines of evidence indicate that a cascade of events, including but not limited to an over-activation of inflammatory pathways, along with oxidative and nitrosative stress (O&NS) and a diminished neurotrophic support lead to neuroprogressive changes (Anderson and Maes, 2015;Berk et al, 2011;Modabbernia et al, 2013;Scola and Andreazza, 2015).…”

Section: Introductionmentioning

confidence: 99%

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Colpo¹,

Leffa

Köhler

et al. 2015

Journal of Affective Disorders

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“…133 More information on their general description, mechanisms of action, and their effects on BD is presented in Scola and Andreazza. 4 Currently, decreased peripheral levels of BDNF represent the most consistent finding replicated in studies of BD and is also considered as a potential peripheral biomarker for assessing disease progression. 2 In addition, more studies are needed to better understand how these interleukins and trophic factors exhibit their activities in a multifaceted environment such as BD.…”

Section: Inflammation and Neurotrophic Factorsmentioning

confidence: 96%

“…These alterations could be directly correlated to dysregulation of the molecular pathways of inflammation and neurotrophins. 3,4 The factors that regulate neurological cells are expressed in a region-specific manner in the brain and the peripheral tissues. This suggests the possibility of using peripheral markers to address alterations in the brain that occur during the development of BD and other psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Biomarkers for bipolar disorder: current insights

Duong¹,

Syed²,

Scola³

2015

CBF

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Abstract:Currently, there exists a lack of definitive diagnostic tools for neuropsychiatric disorders, particularly molecular markers that could help assess the illness and develop more personalized treatments for different disorders. Understanding of the neurobiology and potential novel treatments for bipolar disorder (BD), one of the most complex psychiatric illnesses, remains poor. This review aims to compile the most reproducible findings regarding the molecular, genetic, and structural changes that occur in BD. Neuroimaging studies have indicated alterations in neural circuits, disrupted white matter integrity, alterations in reward activation, and decreased gray matter (GM) volume. Genetic studies have identified variations in a number of genes that confer risk for BD development. Studies involving peripheral biomarkers include alterations in the levels of oxidative stress, inflammation, and neurotrophins. These potential molecular markers could be used as tools for diagnosis, to assess illness progression, and to help with the improvement of more specific and personalized treatments for patients with BD. Identification of biologically relevant markers could improve the quality of life of patients with BD and revolutionize public health.

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The role of neurotrophins in bipolar disorder

Cited by 52 publications

References 80 publications

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies

Is bipolar disorder associated with accelerating aging? A meta-analysis of telomere length studies

Biomarkers for bipolar disorder: current insights

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