The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases

Numakawa, Tadahiro; Odaka, Haruki

doi:10.3390/ijms23147726

Cited by 26 publications

(6 citation statements)

References 95 publications

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“…Downregulation of BDNF expression, which is associated with decreased adult hippocampal neurogenesis, occurs in brains of older adults with decreased learning ability [ 27 , 28 ] and those of patients with major depressive disorders [ 29 ]. Moreover, decreased levels of BDNF expression in older adults could result in impaired memory, neurodegeneration and other cognitive impairments typical of Alzheimer’s disease [ 30 ].…”

Section: Bdnfmentioning

confidence: 99%

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

Amagase

Kambayashi

Sugiyama

et al. 2023

IJMS

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The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain function. In the adult hippocampus, BDNF is critical for maintaining adult neurogenesis. Adult hippocampal neurogenesis is involved not only in memory formation and learning ability, but also mood regulation and stress responses. Accordingly, decreased levels of BDNF, accompanied by low levels of adult neurogenesis, occurs in brains of older adults with impaired cognitive function and in those of patients with major depression disorder. Therefore, elucidating the mechanisms that maintain hippocampal BDNF levels is biologically and clinically important. It has been revealed that signalling from peripheral tissues contribute to the regulation of BDNF expression in the brain across the blood–brain barrier. Moreover, recent studies indicated evidence that neuronal pathways can also be a mechanism by which peripheral tissues signal to the brain for the regulation of BDNF expression. In this review, we give an overview of the current status in the regulation of central BDNF expression by peripheral signalling, with a special interest in the regulation of hippocampal BDNF levels by signals via the vagus nerve. Finally, we discuss the relationship between signalling from peripheral tissues and age-associated control of central BDNF expression.

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Section: Bdnfmentioning

confidence: 99%

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

Amagase

Kambayashi

Sugiyama

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…2). 104 The activation of the PI3k/Akt pathway enhances cell survival, inhibits cell apoptosis and promotes axonal regeneration. The ERK pathway is important for the proliferation and differentiation of neurocytes.…”

Section: 2mentioning

confidence: 99%

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

et al. 2023

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“…NTs are essential for synaptic plasticity and to modulate neuronal biochemical pathways that underlie memory formation as the expression of cAMP Response Element-Binding Protein (CREB) [ 14 , 15 , 16 ]. Indeed, the alteration of the activity and levels of neurotrophic factors are related to cognitive deficits and neurodegenerative diseases [ 17 , 18 ]. For this reason, treatments that modulate neurotrophin levels or direct administration of NTs have acquired a great deal of interest in preventing neurodegeneration, promoting neural regeneration in several pathologies [ 17 , 19 , 20 , 21 ] and results promising for the treatment of spinal cord injury and cerebral ischemia [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Nanoplatforms Based on Graphene Oxide and Neurotrophin-Mimicking Peptides

et al. 2023

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Neurotrophins (NTs), which are crucial for the functioning of the nervous system, are also known to regulate vascularization. Graphene-based materials may drive neural growth and differentiation, and, thus, have great potential in regenerative medicine. In this work, we scrutinized the nano–biointerface between the cell membrane and hybrids made of neurotrophin-mimicking peptides and graphene oxide (GO) assemblies (pep−GO), to exploit their potential in theranostics (i.e., therapy and imaging/diagnostics) for targeting neurodegenerative diseases (ND) as well as angiogenesis. The pep−GO systems were assembled via spontaneous physisorption onto GO nanosheets of the peptide sequences BDNF(1-12), NT3(1-13), and NGF(1-14), mimicking the brain-derived neurotrophic factor (BDNF), the neurotrophin 3 (NT3), and the nerve growth factor (NGF), respectively. The interaction of pep−GO nanoplatforms at the biointerface with artificial cell membranes was scrutinized both in 3D and 2D by utilizing model phospholipids self-assembled as small unilamellar vesicles (SUVs) or planar-supported lipid bilayers (SLBs), respectively. The experimental studies were paralleled via molecular dynamics (MD) computational analyses. Proof-of-work in vitro cellular experiments with undifferentiated neuroblastoma (SH-SY5Y), neuron-like, differentiated neuroblastoma (dSH-SY5Y), and human umbilical vein endothelial cells (HUVECs) were carried out to shed light on the capability of the pep−GO nanoplatforms to stimulate the neurite outgrowth as well as tubulogenesis and cell migration.

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The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases

Cited by 26 publications

References 95 publications

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

Ginsenosides can target brain-derived neurotrophic factor to improve Parkinson's disease

Bioinspired Nanoplatforms Based on Graphene Oxide and Neurotrophin-Mimicking Peptides

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