The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris

Gancevičienė, Rūta; Böhm, Markus; Fimmel, Sabine; Zouboulis, Christos C.

doi:10.4161/derm.1.3.8496

Cited by 63 publications

(53 citation statements)

References 47 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased α-MSH and MC-1R expression in sebaceous glands has been shown in patients with acne in the case of systemic or cutaneous stress. The α-MSH / MC1R interaction has been suggested to be closely related to keratinocyte proliferation and differentiation [14]. In this study, it was observed that SRS amplitude and latency values of AV patients were not different from healthy controls.…”

Section: Discussionsupporting

confidence: 51%

Assessment of sympathetic skin response to acne vulgaris

Polat¹,

Korkmaz²,

Ozlece³

2017

Med-Science

View full text Add to dashboard Cite

Acne vulgaris (AV) is a common pilosebase unit disease characterized by peripheral inflammation. Because it is associated with the peripheral nervous system, the cranial nervous system and the autonomic nervous system, the skin is a neuroimmunoendocrine organ. Various neuroendocrine hormones and catecholamines are also released by keratinocytes, which stimulate inflammation in the pilosebase unit. In this study, sympathetic skin response (SSR) evaluating the sympathetic nervous system function as a reflex against internal and external stimuli in AV will be evaluated. 31 AV patients (mean age: 22.48 ± 2.35, 20 female, 11 male) and 29 healthy volunteers (mean age: 23.19 ± 1.27, 18 female, 11 male) between the ages of 18-30 were included in the study. All patient and control groups were questioned about detailed disease and medication intake history. Dermatologic examination was performed by a single experienced dermatologist, and global acne score (GAS) was calculated. For SSR measurement, both median nerve were warned separately on both wrists. The frequency filters is set to 0.5-2000 Hz and the analysis time is set to about 10 seconds. The SSR latencies were recorded in seconds (s) and the amplitudes were recorded in millivolts (mV). The mean age and sex of the groups were similar (p> 0,05, for each). There was no significant difference between AV and healthy control groups in terms of SSR latencies and amplitudes in both extremes ((p> 0.05, for each) AV patients had a mean GAS of 15.61. There was no correlation between GAS and latency and amplitude values of both extremities in AV patients (p> 0.05). As a result, it was found that SSR did not differ from normal people in AV cases. Changes in the autonomic nervous system in AV should be evaluated with more sensitive tests.

show abstract

Section: Discussionsupporting

confidence: 51%

Assessment of sympathetic skin response to acne vulgaris

Polat¹,

Korkmaz²,

Ozlece³

2017

Med-Science

View full text Add to dashboard Cite

show abstract

“…Так, Ganceviciene и соавт. в 2009 г. было показано, что в сальных железах больных с акне значительно больше рецепторов к основным гормонам стресса, гонадотропин-рилизинг гормону и меланоцит-стимулирующему гормону, чем в сальных железах здоро-вых добровольцев [5].…”

Section: педиатрическая фармакологияunclassified

“…ЛИЧНОСТНЫЕ И ПСИХИЧЕСКИЕ ОСОБЕННОСТИ ДЕТЕЙ И ПОДРОСТКОВ С УГРЕВОЙ БОЛЕЗНЬЮ В подавляющем большинстве случаев угревая сыпь не представляет угрозы для жизни, но при этом ее нали-чие значительно снижает качество жизни [5]. Психо-эмоциональный стресс, связанный с косметическим дефектом, наиболее выражен у лиц подросткового воз-раста [18].…”

Section: педиатрическая фармакологияunclassified

Psycho-Emotional State of Children and Adolescents With Acne

2012

View full text Add to dashboard Cite

Вопросы взаимосвязи патогенеза кожных болез-ней и состояния нервной системы являются наиболее актуальными в современной дерматологии. Известный отечественный дерматолог профессор А. Г. Полотебнов был одним из первых ученых, поставивших психоэмо-циональные расстройства в ряд центральных факторов прогрессирования кожных болезней. Его фундамен-тальный труд «Нервные страдания кожи», написанный в 1886 г. на немецком языке, послужил основой для дальнейшего развития западной психодерматологии.На протяжении ХIX-XX веков психологи и дерма-тологи, наблюдавшие пациентов с угревой болез-нью, концентрировали свое внимание в первую оче-редь на описании психоэмоционального статуса своих пациентов и поиске комплексных подходов к лечению угревой болезни, включавших не только дерматоло-гические средства, но и коррекцию нарушений мен-тальной сферы. В последнее время все больше работ посвящается аспектам функционирования осей «нерв-ная система-кожа» и «нервная система-кишечник-кожа» [1].В настоящем обзоре аспекты психоэмоционально-го состояния детей и подростков с угревой болезнью (L70 по классификации МКБ-10) будут рассмотрены с позиции междисциплинарного подхода.СВЯЗЬ МЕЖДУ СОСТОЯНИЕМ НЕРВНОЙ СИСТЕМЫ И УГРЕВОЙ БОЛЕЗНЬЮ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ Как известно, и кожа, и нервная система имеют экто дермальное происхождение [2], что определяет их неразрывную связь.Применительно к угревой болезни можно выде-лить три основных уровня взаимосвязей ее патогенеза с психоэмоциональным состоянием: 1. Общие генетические факторы и факторы окружаю-щей среды, предопределяющие как развитие угре-вой болезни, так и нарушения ментальной сферы. 2. Провоцирование развития нозогенных психических расстройств косметическим дефектом. 3. Влияние изменений психической сферы на течение угревой болезни.

show abstract

“…However, in lesional skin of patients with acne, another common dermatosis, intra-cellular upregulation of CRH was detected (23). CRH upregulates 3b-HSD at the mRNA level in human SZ95 sebocytes, thus promoting lesional steroidogenesis and subsequently androgen excess, which is known to be one of the major pathophysiological factors of the disease (24).…”

Section: Accepted For Publication 18 July 2014mentioning

confidence: 99%

Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis

Nikolakis

Zouboulis

2014

Experimental Dermatology

Self Cite

View full text Add to dashboard Cite

The role of skin as a de novo source of glucocorticoids and the importance of cutaneous glucocorticoidogenesis as a homeostatic mechanism in human skin is highlighted by Slominski et al. in a recently published issue. Impairment of glucocorticoidogenesis through noxious stimuli, such as UVB, can explain pathophysiology of skin diseases (e.g. rosacea). In addition to keratinocytes, melanocytes and fibroblasts, cutaneous adnexes also play a significant role as targets and sources of glucocorticoids, because they express most of the enzymes required for steroidogenesis. Glucocorticoids are also involved in the pathogenesis of acne lesions, affecting sebum production in vivo and in vitro. Certain steroidogenic enzymes, such as 11b-hydroxysteroid dehydrogenase, are upregulated in acne lesions. On this background, the paper by Slominski et al. provides further insights into dermatoendocrinology, with emphasis on the importance of an impairment of the skin's own hypothalamic-pituitary-adrenal-like axis in the pathophysiology of several skin diseases.

show abstract

The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris

Cited by 63 publications

References 47 publications

Assessment of sympathetic skin response to acne vulgaris

Assessment of sympathetic skin response to acne vulgaris

Psycho-Emotional State of Children and Adolescents With Acne

Skin and glucocorticoids: effects of local skin glucocorticoid impairment on skin homeostasis

Contact Info

Product

Resources

About