The Role of Neurokinin 1 Receptors in the Maintenance of Visceral Hyperalgesia Induced by Repeated Stress in Rats

Bradesi, Sylvie; Kokkotou, Efi; Simeonidis, Simos; Patierno, Simona; Ennes, Helena S.; Mittal, Yash; McRoberts, James A.; Ohning, Gordon V.; McLean, Peter G.; Marvizón, Juan Carlos G.; Sternini, Catia; Pothoulakis, Charalabos; Mayer, Emeran A.

doi:10.1053/j.gastro.2006.01.037

Cited by 48 publications

(44 citation statements)

References 65 publications

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“…The specificity of the antibody used was confirmed in our previous study (Kido et al 1999) and other reports (Bradesi et al 2006;Kuramoto et al 2007).…”

Section: Immunolight and Immunoelectron Microscopy Controlssupporting

confidence: 82%

Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats

et al. 2008

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We examined the distribution of substance P and neurokinin-1 (NK1) receptors and substance-P-containing nerve fibers in the peri-implant mucosa around titanium dental implants in rats. Immunohistochemistry and immunocytochemistry revealed that substance-P-immunoreactive nerve fibers abundantly innervated the peri-implant epithelium (PIE) compared with other epithelia of the peri-implant mucosa. NK1 receptor mRNA and protein expression in the peri-implant mucosa were confirmed by reverse transcription with the polymerase chain reaction and immunoblotting. Immunoelectron microscopy revealed that NK1 receptor immunoreactivity was preferentially localized in peri-implant epithelial cells. NK1-receptor-positive products were found on the plasma membrane and in vesicles and granules in PIE cells. Neutrophils and intraepithelial nerve axons in the PIE were positive for the NK1 receptor. NK1 receptor immunoreactivity was also detected in endothelial cells, fibroblasts, and nerve fibers in the connective tissue beneath the PIE. These findings suggest that peri-implant tissue receives sensory information through regenerated nerves expressing substance P and the NK1 receptor. In the peri-implant mucosa, the substance P/NK1 receptor system may play a role in pain transmission, the endocytosis of neutrophils, the extravasation of crevicular fluid, and the migration of macrophages and neutrophils in response to neurogenic inflammation, as in healthy gingiva.

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“…The specificity of the antibody used was confirmed in our previous study (Kido et al 1999) and other reports (Bradesi et al 2006;Kuramoto et al 2007).…”

Section: Immunolight and Immunoelectron Microscopy Controlssupporting

confidence: 82%

Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats

et al. 2008

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“…In vivo studies showed that SR-140333 and MEN-10930, 2 selective antagonists of NK1 receptors, possess significant alleviating effects on inflammatory associated hyperalgesia. [73][74][75] Different animal studies have confirmed that nepadutant and saredutant, 2 NK2 antagonists, can significantly modulate the colorectal hypersensitivity to distension. Talnetant, SB-223412, and SR-142801 are amongst the selective antagonists of NK3 receptors.…”

Section: Tachykininsmentioning

confidence: 99%

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Farzaei

Bahramsoltani

Abdollahi

et al. 2016

J Neurogastroenterol Motil

150

122

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Irritable bowel syndrome (IBS) is the most common disorder referred to gastroenterologists and is characterized by altered bowel habits, abdominal pain, and bloating. Visceral hypersensitivity (VH) is a multifactorial process that may occur within the peripheral or central nervous systems and plays a principal role in the etiology of IBS symptoms. The pharmacological studies on selective drugs based on targeting specific ligands can provide novel therapies for modulation of persistent visceral hyperalgesia. The current paper reviews the cellular and molecular mechanisms underlying therapeutic targeting for providing future drugs to protect or treat visceroperception and pain sensitization in IBS patients. There are a wide range of mediators and receptors participating in visceral pain perception amongst which substances targeting afferent receptors are attractive sources of novel drugs. Novel therapeutic targets for the management of VH include compounds which alter gut-brain pathways and local neuroimmune pathways. Molecular mediators and receptors participating in pain perception and visceroperception include histamine-1 receptors, serotonin (5-hydrodytryptamine) receptors, transient receptor potential vanilloid type I, tachykinins ligands, opioid receptors, voltage-gated channels, tyrosine receptor kinase receptors, protease-activated receptors, adrenergic system ligands, cannabinoid receptors, sex hormones, and glutamate receptors which are discussed in the current review. Moreover, several plant-derived natural compounds with potential to alleviate VH in IBS have been highlighted. VH has an important role in the pathology and severity of complications in IBS. Therefore, managing VH can remarkably modulate the symptoms of IBS. More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH. (J Neurogastroenterol Motil 2016;22:558-574)

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“…Visceral hyperalgesia (Bradesi et al, 2009(Bradesi et al, , 2007(Bradesi et al, , 2006He et al, 2013;Larauche et al, 2008 (Chen et al, 2011;Green et al, 2011b) Chapter 1…”

Section: Colorectal Distensionmentioning

confidence: 99%

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

Madasu

Okine

Olango

et al. 2016

Pharmacological Research

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The Role of Neurokinin 1 Receptors in the Maintenance of Visceral Hyperalgesia Induced by Repeated Stress in Rats

Cited by 48 publications

References 65 publications

Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats

Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey

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