The role of neuroinflammation on the pathogenesis of Parkinson's disease

Chung, Young Cheul; Ko, Hyuk Wan; Bok, Eugene; Park, Eun Su; Huh, Sue H.; Nam, Jung‐Hwan; Jin, Byung Kwan

doi:10.5483/bmbrep.2010.43.4.225

Cited by 140 publications

(130 citation statements)

References 78 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Immune cell trafficking to the CNS has also been found to occur in other neurodegenerative conditions such as AD, Parkinson's disease and neuroAIDS and is thought to contribute to varying extents to disease progression. In Parkinson's disease, T lymphocytes are present in the midbrain, and leukocyte infiltration occurs in brains of mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [77] . Furthermore, mice deficient in CD4 are resistant to MPTP-induced neurotoxicity in the substantia nigra [77] .…”

Section: Diseases Involving the Bbb And Neuroimmune Mechanismsmentioning

confidence: 99%

“…In Parkinson's disease, T lymphocytes are present in the midbrain, and leukocyte infiltration occurs in brains of mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) [77] . Furthermore, mice deficient in CD4 are resistant to MPTP-induced neurotoxicity in the substantia nigra [77] . In the context of AD, evidence suggests that circulating immune cells of monocyte lineage enter the CNS and can effectively clear amyloid-␤ (A ␤ ) from the brain [78] .…”

Section: Diseases Involving the Bbb And Neuroimmune Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

Erickson

Dohi²,

Banks³

2012

Neuroimmunomodulation

198

134

View full text Add to dashboard Cite

The blood-brain barrier (BBB) is not simply a physical barrier but a regulatory interface between the central nervous system (CNS) and immune system. The BBB both affects and is affected by the immune system and connects at many levels with the CNS, including the following: (1) the BBB transports cytokines and secretes various substances with neuroinflammatory properties; (2) transporters are altered in disease states including traumatic injury, Alzheimer’s disease and inflammatory processes; (3) cytokines and other immune secretions from the cells comprising the BBB are both constitutive and inducible; (4) immune cells are transported across the BBB by the highly regulated process termed diapedesis, which involves communication and interactions between the brain endothelial cells and the immune cells; (5) the neuroimmune system has various effects on the BBB, including modulation of important transport systems and in extreme pathological conditions even disruption of the BBB, and (6) the brain-to-blood efflux transporter P-glycoprotein is altered in inflammatory conditions, thus affecting drug delivery to the brain. In summary, the BBB is an interactive interface that regulates and defines many of the ways that the CNS and the immune system communicate with one another.

show abstract

Section: Diseases Involving the Bbb And Neuroimmune Mechanismsmentioning

confidence: 99%

Section: Diseases Involving the Bbb And Neuroimmune Mechanismsmentioning

confidence: 99%

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

Erickson

Dohi²,

Banks³

2012

Neuroimmunomodulation

198

134

View full text Add to dashboard Cite

show abstract

“…+ is a well-known neurotoxin that can induce neuronal cell death by generating reactive oxygen species (ROS) and DNA damage (11,23,24). To determine whether the transduced PEP-1-p18 has a functional role in neuronal cell death, we examined the effect of MPP + on cell viability.…”

Section: Mppmentioning

confidence: 99%

PEP-1-p18 prevents neuronal cell death by inhibiting oxidative stress and Bax expression

Kim

Sohn²,

Kim³

et al. 2012

BMB Reports

View full text Add to dashboard Cite

“…Activated glia have an up-regulated expression of cellular adhesion molecules and the subsequent induction of chemokine gradients direct peripheral leucocytes to the site of inflammation (Chung et al, 2010;Stone et al, 2009). Indeed, positron emission tomography (PET) and histological studies of PD patients as well as MPTP and LPS-induced models of PD reveal a pathogenic link between neuroinflammation, increased BBB permeability and the consequent infiltration of systemic inflammatory molecules, and DA neuronal death (Chung et al, 2010). PD patients have a reported dysfunction in the BBB transporter system (Kortekaas et al, 2005) and blood vessels in the midbrain (Faucheux et al, 1999).…”

Section: Systemic Inflammation and Parkinson's Diseasementioning

confidence: 99%