The role of neuroinflammation in the pathogenesis of epilepsy

Abstract

1192019, Санкт-Петербург, ул. Бехтерева, 3; 2 191015, Санкт-Петербург, ул. Кирочная, 41 За

Biomarkers of Drug Resistance in Temporal Lobe Epilepsy in Adults

“…A number of studies have shown a correlation between the severity of epileptic seizures and increased levels of cytokines in the blood plasma ( HMGB-1 , TLR4 , IL-1β , IL-1R1 , and TNF-α ) of patients with drug-resistant epilepsy [ 17 , 27 ]; increased levels of cytokines have also been observed in cerebrospinal fluid ( IL-1β ) [ 16 , 28 ]. The impairment of the profile of pro-inflammatory cytokines in plasma ( IL-1β , IL-6 , IL-8 , TNF-α ) also correlates with the frequency of seizures [ 29 ].…”

“…Experimental and clinical data demonstrate that neuroinflammation and neurodegeneration involved in epileptogenesis make a significant contribution to the development of drug resistance and the chronicity of TLE [ 16 , 17 ]. The mechanism of development of neuroinflammation and neurodegeneration in TLE has been studied in experimental models as well as in clinical samples of biological fluids and tissues of patients [ 17 , 18 , 19 ].…”

“…Experimental and clinical data demonstrate that neuroinflammation and neurodegeneration involved in epileptogenesis make a significant contribution to the development of drug resistance and the chronicity of TLE [ 16 , 17 ]. The mechanism of development of neuroinflammation and neurodegeneration in TLE has been studied in experimental models as well as in clinical samples of biological fluids and tissues of patients [ 17 , 18 , 19 ]. In TLE cases with hippocampal sclerosis (HS), there is a progressive loss of neurons and gliosis in the hippocampus and amygdala, which may be caused by uncontrolled processes of neuroinflammation and neurodegeneration accompanied by disruptions in the blood–brain barrier and damage to brain cells [ 20 ].…”

Neuroinflammatory Dysfunction of the Blood–Brain Barrier and Basement Membrane Dysplasia Play a Role in the Development of Drug-Resistant Epilepsy

“…In the studied blood plasma samples, the content of pro-inflammatory IL-1β and its natural anticonvulsant antagonist IL-1RA did not differ significantly from their content in the group of patients without epilepsy. However, there are data indicating a decrease in IL-1RA/IL-1β after an attack [26]. Such differences may be due to the fact that we took blood during the seizure-free period established in the hospital, while other researchers take blood for analysis immediately after a seizure or after a certain time.…”

Association of the carriage of IL-1B rs1143634 and rs16944 polymorphisms and BDNF rs6265 polymorphism with temporal lobe epilepsy

“…У пациентов с медиобазальной височной эпилепсией и склерозом гиппокампа в сыворотке крови обнаружена гиперэкспрессия ИЛ1β [16]. А повышенный уровень ИЛ1β в цереброспинальной жидкости у больных эпилепсией свидетельствует о нарушении гематоэнцефалического барьера и системном воспалении [17]. Выяв-лен ряд точечных маркеров высокопродуцирующего аллельного варианта гена IL1B, наследуемых чаще сцепленно (3953, -3737, -1469, -999).…”