The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation

Wadugu, Brian A.; Kühn, Bernhard

doi:10.1152/ajpheart.00063.2012

Cited by 114 publications

(92 citation statements)

References 98 publications

(143 reference statements)

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“…This pathway normally acts as a response/repair mechanism to a broad range of myocardial injury. 7 Administration of trastuzumab blocks the ErbB2 receptor, leading to potential myocardial injury via disruption of repair mechanisms. Myocardial trastuzumab uptake is particularly common shortly after anthracycline administration, providing mechanistic evidence to support the clinical observation of the high rates of cardiotoxicity when these agents are used in close temporal relationship to one another.…”

Section: Mechanisms Of Cardiotoxicitymentioning

confidence: 99%

Myocardial Protection During Cardiotoxic Chemotherapy

Witteles

Bosch

2015

Circulation

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Section: Mechanisms Of Cardiotoxicitymentioning

confidence: 99%

Myocardial Protection During Cardiotoxic Chemotherapy

Witteles

Bosch

2015

Circulation

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“…Among the podcasts we produced on the overarching topic of signaling and stress response (34,63,99), several featured articles emerged as seminal discussions. We brought the complexities and importance of O-linked N-acetylglucosamine signaling into context by exploring the work of Facundo et al (25).…”

Section: Podcastsmentioning

confidence: 99%

“…Using a unique and innovative large animal model, Walker et al (101) focused on the oft-ignored issue of right ventricular cardiac disease. The groundbreaking research by Ma et al (56) provided a platform to discuss new methods for generating large quantities of cultured cardiac myocytes using embryoid body formation and blasticidin selection techniques.Among the podcasts we produced on the overarching topic of signaling and stress response (34,63,99), several featured articles emerged as seminal discussions. We brought the complexities and importance of O-linked N-acetylglucosamine signaling into context by exploring the work of Facundo et al (25).…”

mentioning

confidence: 99%

Update on innovative initiatives for the American Journal of Physiology-Heart and Circulatory Physiology

Stanley

Keehan²

2013

American Journal of Physiology-Heart and Circulatory Physiology

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WE WOULD LIKE TO UPDATE the readership of the American Journal of Physiology-Heart and Circulatory Physiology on the progress we have made in instituting the plan we laid out two years ago when we assumed the editorship of this venerable journal. We have expanded the content and features of the journal and have further enhanced the review process. Our time for manuscript review is an impressive 18 days from submission to first decision, and we have put great emphasis on providing authors with unambiguous decisions letters that provide clear and helpful guidance for a successful revision. Our look has changed with the elimination of the print version of the journal, the publication of two issues each month, the division of the table of contents into subspecialties of cardiovascular physiology, and the launch of article collections on hot topics. PodcastsOur principal new feature is the editorial podcast, an audio interview with key contributors aimed at providing unique insights into a featured article. These brief discussions (Ͻ10 min) with an author and a leading expert accompany "hot topic" papers published in the journal and are moderated by our editorial team. In our first two years we recorded 52 podcasts, which are posted online on our journal homepage (http:// ajpheart.physiology.org) and as supplements to the e-articles. Our goal is to make our podcasts easily discoverable via numerous access points, which include posting on our dedicated podcast web server (http://ajpheart.podbean.com), as well as offering podcasts via RSS feed and iTunes. Based on listener feedback and over 9,000 downloads, our podcasts are clearly a success.We have generated podcasts in all subdisciplines of cardiovascular physiology. We produced several podcasts in the field of vascular biology and microcirculation (7, 8, 10, 23,33,34,39,41,53,57,58,67,76,105,106,115,116), and we wish to highlight several key podcasts here. We discussed a human study that looked at the central blood pressure response to the cyclooxygenase inhibitor indomethacin in both old and young healthy adults (5), which addressed the question: What happens when you combine nonsteroidal anti-inflammatory drug-type pain medication and aging-induced arterial stiffening? In conjunction with the 2012 London Summer Olympics Games, we talked with Dick Thijssen (Liverpool John Moores University) about his work on the effects of preconditioning ischemic stimulus applied to the legs of elite athletes as a protection against endothelial dysfunction in the arms after a 5-km run (4). We also tackled the controversial subject of arterial function following menopause in an attempt to understand more clearly whether early intervention with estrogen therapy may combat accelerated vascular aging after menopause (62). In our podcast on the work by Sperandio et al. (85), we discuss how sildenafil, a phosphodiesterase-5 inhibitor, progressed first from ineffective treatment for ischemic heart disease, then later to a widely used treatment for erectile dysfunction, and now to current...

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“…Past studies have shown that cardiomyocyte hyperplastic growth occurs in response to input from a large network of growth factor signaling pathways (Lavine et al, 2005;Ahuja et al, 2007;Bersell et al, 2009;Heallen et al, 2011;Porrello et al, 2011;Xin et al, 2011Xin et al, , 2013Eulalio et al, 2012;von Gise et al, 2012;Wadugu and Kuhn, 2012). However, many basic questions regarding the mechanisms underlying how these growth factors regulate the cardiomyocyte cell cycle remain unanswered.…”

Section: Introductionmentioning

confidence: 99%

Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development

Dorr

Amin

et al. 2015

Development

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Organ growth occurs through the integration of external growth signals during the G1 phase of the cell cycle to initiate DNA replication. Although numerous growth factor signals have been shown to be required for the proliferation of cardiomyocytes, genetic studies have only identified a very limited number of transcription factors that act to regulate the entry of cardiomyocytes into S phase. Here, we report that the cardiac para-zinc-finger protein CASZ1 is expressed in murine cardiomyocytes. Genetic fate mapping with an inducible Casz1 allele demonstrates that CASZ1-expressing cells give rise to cardiomyocytes in the first and second heart fields. We show through the generation of a cardiac conditional null mutation that Casz1 is essential for the proliferation of cardiomyocytes in both heart fields and that loss of Casz1 leads to a decrease in cardiomyocyte cell number. We further report that the loss of Casz1 leads to a prolonged or arrested S phase, a decrease in DNA synthesis, an increase in phospho-RB and a concomitant decrease in the cardiac mitotic index. Taken together, these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields.

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The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation

Cited by 114 publications

References 98 publications

Myocardial Protection During Cardiotoxic Chemotherapy

Myocardial Protection During Cardiotoxic Chemotherapy

Update on innovative initiatives for the American Journal of Physiology-Heart and Circulatory Physiology

Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development

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