The role of natural killer cells in innate resistance to infection

Bancroft, Gregory J.

doi:10.1016/0952-7915(93)90030-v

Cited by 290 publications

(186 citation statements)

References 54 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…18 The liver also plays a key role in the innate immune response by influencing the homing and differentiation of NK cells. [31][32][33][34] Up to 65% of all lymphocytes present in the normal liver consists of NK cells, NKT cells, and cd T cells, and the frequency of NK cells among human intrahepatic lymphocytes ranges between 25% and 30%. 31,32 Furthermore, NK cells are located in the liver sinusoids, adherent to the liver sinusoidal endothelial cells and, thus, are well situated to eliminate arriving metastasizing tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Patient survival by Hsp70 membrane phenotype

Pfister

Radons

Busch

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUNDHeat shock proteins (HSPs) play important roles in tumor immunity. The authors prospectively investigated the correlation between the tumor‐specific Hsp70 membrane expression as an independent clinicopathological marker and overall survival in tumor entities that differ in their route of metastasis.METHODSHsp70 membrane expression was examined by flow cytometry in 58 colon, 19 gastric, 54 lower rectal carcinoma, and 19 squamous cell carcinoma specimens and the corresponding normal tissues at time of first diagnosis. Kaplan‐Meier survival curves were analyzed to determine the relation of Hsp70 expression to the patients' prognosis.RESULTSAn Hsp70 membrane‐positive phenotype was found in 40% (colon), 37% (gastric), 43% (lower rectal), and 42% (squamous cell) of the analyzed tumor specimens. None of the corresponding normal tissues was found to be Hsp70 membrane‐positive. In patients with colon (P = .032) and gastric (P = .045) carcinomas, an Hsp70 membrane expression correlated significantly with an improved overall survival; a negative association was seen in lower rectal (P = .085) and squamous cell carcinoma (P = .048).CONCLUSIONSThe authors hypothesized that differing relations between surface expression of Hsp70 on tumor cells and clinical outcomes may reflect differences in the route of metastases. Colon and gastric carcinomas metastasize into the liver where hepatic natural killer cells may have the capacity to recognize and kill Hsp70 membrane‐positive tumor cells and thus account for a better overall survival. Cancer 2007; 110:926–35. © 2007 American Cancer Society.

show abstract

Section: Discussionmentioning

confidence: 99%

Patient survival by Hsp70 membrane phenotype

Pfister

Radons

Busch

et al. 2007

Cancer

View full text Add to dashboard Cite

show abstract

“…4,5,7 Malignant cells derived from epithelial tissues are, in general, resistant to the lytic effects of naive NK cells but are susceptible to lysis by lymphokine-activated NK cells. 7,8 Discovery and characterization of the receptor-ligand systems utilized by naive and activated NK cells have been important to an understanding of the mechanisms by which these lymphocytes provide protection against cancerous diseases.…”

Section: Semiquantitative Analysis Of P385 Gene Transcriptionmentioning

confidence: 99%

“…Interestingly, surface expression of p38.5 was only detected in tumor cell lines that were susceptible to lysis mediated by naive natural killer (NK) cells. NK cells are an important cellular component of the innate immune system 4,5 that are capable of destroying certain malignant cells without prior antigenic stimulation. 6,7 Further studies suggested that p38.5 might play a role in naive NK cell-mediated destruction of hematopoetic tumor cells since the protein specifically bound to NK cells (but not to T lymphocytes) and preincubation of NK cells with the purified protein inhibited cytotoxicity.…”

mentioning

confidence: 99%

Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells

et al. 2001

View full text Add to dashboard Cite

Previous studies from our laboratory revealed a novel protein of 38.5 kD on the surface of malignant cell lines of hematopoetic origin that exhibit susceptibility to naive natural killer (NK) cell-mediated lysis. In contrast, p38.5 was not detected on the surface of NK cell-resistant carcinoma cell lines or normal cells. We now report that this protein is differentially expressed, intracellularly, in malignant cell lines of both hematopoetic and epithelial origin compared with nonmalignant cells. To characterize p38.5 further, we used a previously developed antipeptide antibody (anti-11-mer) to probe cDNA expression libraries and subsequently per-

show abstract

“…This has led to the hypothesis that optimal immune responses in the liver require the presence of NK cells. The role of these cells in the immune response has long been an area of intense interest since these cells may provide a first line of defence against invading infectious pathogens such as viruses, bacteria and parasites [3,23] by exerting effector functions without having to be primed [9]. The activation of NK cells in response to certain pathogens involves an increased cytolytic capacity as well as the induction of cytokine production.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats

Tliba

Chauvin²,

Vern

et al. 2002

Vet. Res.

View full text Add to dashboard Cite

-The in situ distribution of NK cells in rat liver during the first 28 days of an experimental infection with F. hepatica was investigated. NK cells were distributed homogeneously throughout the hepatic parenchyma in uninfected animals. The total number of hepatic mononuclear cells increased significantly following infection, but the proportion of NK cells did not change. After infection, these cells were found around the portal space, around the centrolobular vein, in the periportal fibrosis and in the band of collagen. However, no NK cells could be detected in or around the granuloma during infection. The frequency of both IL-2-and IFNγ -producing NK cells was higher on day 7 postinfection (pi) but only the percentage of IFNγ + CD161 + subsets remained elevated thereafter, whereas the percentage of both IL-2 + CD161 + and IL-4 + CD161 + subsets returned to the baseline. The number of CD161 + IL10 + cells did not change significantly. These results suggest that NK cells could be another source for the early production of IFNγ but provide no evidence that these cells are involved in early events associated with granuloma formation. Fasciola hepatica / NK cells / cytokine / flow cytometry / immunohistochemistryRésumé -Évaluation de la réponse des cellules NK hépatiques pendant la phase précoce d'infestation par Fasciola hepatica chez le rat. Nous avons suivi la localisation et la distribution hépatique des cellules NK durant les 28 premiers jours d'une fasciolose expérimentale chez le rat. Chez les animaux non infestés, les cellules NK sont distribuées de façon homogène dans tout le foie. Chez les animaux infestés, ces cellules sont localisées préférentiellement au niveau des espaces portes, autour des veines centrolobulaires, dans les bandes de collagène et dans la zone de fibrose péri-portale. En revanche, aucune de ces cellules n'a été détectée ni autour ni au sein du granulome. Le

show abstract

The role of natural killer cells in innate resistance to infection

Cited by 290 publications

References 54 publications

Patient survival by Hsp70 membrane phenotype

Patient survival by Hsp70 membrane phenotype

Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells

Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats

Contact Info

Product

Resources

About