The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium

Khang, Dongwoo; J, Lu; Yao, Chung-Chen Jane; Haberstroh, Karen M.; Webster, Thomas J.

doi:10.1016/j.biomaterials.2007.11.009

Cited by 394 publications

(286 citation statements)

References 25 publications

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“…In old age, human blood circulation and cardiovascular compensatory mechanisms deteriorate, enhancing the risk for high cholesterol, hypertension, diabetes, cerebrovascular disease, obstructive sleep apnea (OSA), ventricular hypertrophy, ischemic heart disease, myocardial infarction, and related cancers (Cheitlin 2003;Khang et al 2008). These are all serious issues that middle-aged people in modern society must face as they age.…”

Section: Introductionmentioning

confidence: 99%

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Lai

Kuo³

et al. 2014

AGE

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Cardiovascular disease is the second leading cause of death (9.1 %) in Taiwan. Heart function deteriorates with age at a rate of 1 % per year. As society ages, we must study the serious problem of cardiovascular disease. SIRT1 regulates important cellular processes, including anti-apoptosis, neuronal protection, cellular senescence, aging, and longevity. In our previous studies, rats with obesity, high blood pressure, and diabetes exhibiting slowed myocardial performance and induced cell apoptosis were reversed via sports training AGE (2014) 36:9706

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Section: Introductionmentioning

confidence: 99%

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Lai

Kuo³

et al. 2014

AGE

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“…Proofs of these statements are presented in publications [9][10][11][12][13][14][15][16][17][18]. There are materials similar to the structure of the tissue.…”

Section: An Important Aspect In the Development Of An Effective Treatmentioning

confidence: 98%

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

Major¹

2015

Archives of Metallurgy and Materials

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I dedicate this work to my Father, who is also my Mentor.He has enabled me to execute my professional passion.The paper presents the main achievements of the author on the development of blood contacting materials. The main objective of the work is to elaborate materials dedicated for the heart support systems. Appropriately designed biomaterial surfaces enable fully controlled cellular differentiation, proliferation, and even restoration of the tissue structure on solids. The paper presents two approaches to modify the surface, which can control the life processes of tissue. The first solution considers the topography in the form of cell niches. The main objective of the study is a modified surface of thin films deposited on the polymer substrate constituting the microenvironment for the cells caused by residual stress and optimized stiffness of the surface using the plasma methods. The research hypothesis was the plasma surface modification method generating a controlled contribution of residual stress in the coating affect the surface topography in the form of nano-wrinkles similar to the niches in the tissue environment. Topography and stiffness of the surface coating allows the targeted cellular differentiation. The properly formed surface topography effectively inhibits blood clotting processes. The second solution considers implementation of self-organizing feature of extracellular matrix like coatings and selective cell mobilization. The multiscale analysis and phenomenologic description were performed to experimental research. For this purpose, the deposition method was based on electrostatic interactions in polyelectrolytes. This type of cell-polymer structure imitate the native structures.Keywords: Surface modification, cell-material interaction, tissue precursors, materials for regenerative medicine Praca przedstawia najważniejsze osiągniecia autora dotyczące rozwoju materiałów do kontaktu z krwią. Głównym celem prowadzonych prac są materiały o przeznaczeniu w komorach wspomagania serca. Odpowiednio zaprojektowana powierzchnia biomateriału umożliwia w pełni kontrolowane różnicowanie komórkowe, proliferację i nawet odtworzenie struktury tkanki na ciele stałym. W pracy przedstawiono dwa podejścia modyfikacji powierzchniowej, które pozwalają sterować procesami życio-wymi tkanki. Pierwszym rozwiązaniem są powłoki o topografii nisz komórkowych. Celem głównym badań jest zmodyfikowana powierzchnia materiałów cienkowarstwowych nałożonych na podłoże polimerowe stanowiąca mikrośrodowisko dla wychwytu i kontrolowanego różnicowania komórek uzyskane przez odpowiedni udział naprężeń własnych i zoptymalizowaną sztywność powierzchniową. Ukierunkowana mikrostrukturą i właściwościami powierzchniowymi monowarstwa hamuje procesy wykrzepiania krwi. Drugie rozwiązanie dotyczy powłok o strukturze macierzy zewnątrzkomórkowej. Celem badań jest wieloskalowa analiza i opis fenomenologiczny samoorganizujących się powłok z funkcją selektywnej mobilizacji komórkowej. Jest to nowoczesne podejście na poziomie badań eksperymentalnyc...

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“…Two of the most common bulk techniques are: making the surface more hydrophilic through a variety of processes such as plasma etching [6,[20][21][22][23]; or modifying the surface with a hydrophilic polymer such as polyethylene glycol [24][25][26][27][28][29][30]. Other methodologies have used smallscale modifications at the micro-and nanolevels to create patterned surfaces that can regulate protein and cellular behaviour [31][32][33][34][35][36]. Creating patterns on a surface can result from either top-down or bottom-up processes.…”

Section: (B) Engineering Surfaces To Control Protein Adsorptionmentioning

confidence: 99%

Designing nanostructured block copolymer surfaces to control protein adhesion

Schricker

Palacio

Bhushan

2012

Phil. Trans. R. Soc. A.

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The profile and conformation of proteins that are adsorbed onto a polymeric biomaterial surface have a profound effect on its in vivo performance. Cells and tissue recognize the protein layer rather than directly interact with the surface. The chemistry and morphology of a polymer surface will govern the protein behaviour. So, by controlling the polymer surface, the biocompatibility can be regulated. Nanoscale surface features are known to affect the protein behaviour, and in this overview the nanostructure of self-assembled block copolymers will be harnessed to control protein behaviour. The nanostructure of a block copolymer can be controlled by manipulating the chemistry and arrangement of the blocks. Random, A-B and A-B-A block copolymers composed of methyl methacrylate copolymerized with either acrylic acid or 2-hydroxyethyl methacrylate will be explored. Using atomic force microscopy (AFM), the surface morphology of these block copolymers will be characterized. Further, AFM tips functionalized with proteins will measure the adhesion of that particular protein to polymer surfaces. In this manner, the influence of block copolymer morphology on protein adhesion can be measured. AFM tips functionalized with antibodies to fibronectin will determine how the surfaces will affect the conformation of fibronectin, an important parameter in evaluating surface biocompatibility.

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The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium

Cited by 394 publications

References 25 publications

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

Designing nanostructured block copolymer surfaces to control protein adhesion

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