The role of naftopidil in the management of benign prostatic hyperplasia

Hara, Noboru; Mizusawa, Takaki; Obara, Kenji; Takahashi, Kota

doi:10.1177/1756287212461681

Cited by 18 publications

(13 citation statements)

References 36 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As naftopidil can inhibit the release of adenosine triphosphate (ATP) from the bladder epithelium (8,27), it may facilitate the afferent nerves and evoke the micturition reflex. Clinical studies that have examined the various agents that can improve urine storage symptoms have demonstrated that naftopidil exhibits a clear superiority over the other α1A blockers (6). This action may be related to multiple effects on the cerebrum, spinal cord, and bladder epithelium.…”

mentioning

confidence: 99%

Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

View full text Add to dashboard Cite

The α1D/A receptor antagonist, naftopidil, inhibits micturition reflex by acting on various different sites. We examined the effects of naftopidil on bladder activity and changes in the induced urinary frequency using female rats with pelvic venous congestion (PC). Twenty-four female rats were divided into sham, PC, and PC/naftopidil groups. After anesthetizing rats in the PC and PC/naftopidil groups, the bilateral common iliac veins and uterine veins were ligated. Rats in the sham and PC groups were fed a standard diet, while rats in the PC/naftopidil group were fed diets containing 0.04% naftopidil. After 4 weeks of treatment, locomotor activity, urinary nitric oxide metabolites (NOx), continuous cystometry, and plasma monoamine measurements were performed. PC rats exhibited a decrease of locomotor activity, a shorter interval between bladder contractions on continuous cystometry, and decreased urinary NOx and plasma serotonin levels than the sham rats. The PC/naftopidil rats exhibited an increase of locomotor activity, a longer interval between bladder contractions, and increased urinary NOx and plasma serotonin levels. Therefore, naftopidil might improve bladder dysfunction induced by pelvic venous congestion due to several actions in the central nervous system and bladder tissue, as well as acting as an α1 blocker to cause pelvic venous dilation.Unilateral or bilateral ovarian vein incompetence can cause pelvic congestion syndrome, which induces chronic pain, irritable bladder, dysfunction of the pelvic organs, or vulval varices and varicose veins in the lower limbs (1, 5, 7). Our previous study demonstrated that chronic prostatitis and stress urinary incontinence were related to the existence of vena cava reflux caused by tricuspid regurgitation (28). When we examined a female case with pelvic congestion syndrome using external iliac venography, we found that pelvic venous congestion occurred with tricuspid regurgitation and without pelvic venous valves (25). Our previous studies have also demonstrated that ligation of the bilateral common iliac veins in male rats or ligation of the bilateral common iliac veins and uterine veins in female rats induced changes in the urinary frequency and low locomotor activity (30). As compared to the intact rats, these surgically altered rats exhibited a bladder blood flow decrease that was about 80% of the flow in the intact bladder. Therefore, pelvic venous congestion may be one of the causes of pelvic ischemia, and might be related to several lower urinary tract symptoms/diseases. When examining hypertension, the relevance of lower urinary tract symptoms and their association with hypertension need to be taken into consideration. Spontaneously hypertensive rats have been shown to have a significantly lower bladder capacity and voiding volume (24), and these rats also exhibit

show abstract

mentioning

confidence: 99%

Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous congestion

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Biomed. Res.

View full text Add to dashboard Cite

show abstract

“…For example, nonselective AR antagonist alfuzosin causes hypotension without ejaculation problems; on the other hand, tamsulosin causes ejaculation problems without hypotension [24,25]. Meanwhile naftopidil shows minimal effects on the cardiovascular system and ejaculatory function [26]. Further studies of add-on therapy to maximize the treatment efficacy or minimize the side effects might provide an opportunity to find a new modality.…”

Section: Discussionmentioning

confidence: 99%

Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

Moon

Kim

et al. 2016

Int Neurourol J

View full text Add to dashboard Cite

PurposeOveractive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats.MethodsThe OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days. The experimental groups were divided into 5 groups: control group, OAB-induction group, OAB-induction and tamsulosin monotherapy group, OAB-induction and naftopidil monotherapy group, and OAB-induction and tamsulosin-naftopidil combination therapy group. For the drug-treated groups, each drug was administrated for 14 days after the OAB induction. Cystometry for urodynamic evaluation and immunohistochemical stain for c-Fos and nerve growth factor (NGF) expressions in the central micturition centers were performed.ResultsIncreased contraction pressure and time with enhanced c-Fos and NGF expressions in the central micturition centers were found in the OAB rats. Tamsulosin suppressed contraction pressure and time while inhibiting c-Fos and NGF expressions. Naftopidil showed no significant effect and combination therapy showed less of an effect on contraction pressure and time. Naftopidil and combination therapy exerted no significant effect on the c-Fos and NGF expressions.ConclusionsTamsulosin showed the most prominent efficacy for the treatment of OAB compared to the naftopidil and combination. The combination of tamsulosin with naftopidil showed no synergistic effects on OAB; however, further studies of addon therapy might provide opportunities to find a new modality.

show abstract

“…Naftopidil, an α1D/A blocker, attenuates urethral outflow resistance in smooth muscle relaxation of the bladder neck and prostatic urethra, and is used to treat benign prostatic hyperplasia . Clinically, the effect of naftopidil is excellent compared to other α1 blockers for urine storage disorders such as nocturia . In animal experiments, microinjection of naftopidil into the medial frontal lobe or intrathecal injection of naftopidil suppresses the micturition reflex .…”

Section: Introductionmentioning

confidence: 99%

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

Sugaya¹,

Nishijima²,

Kadekawa³

et al. 2016

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

The role of naftopidil in the management of benign prostatic hyperplasia

Cited by 18 publications

References 36 publications

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

<b>Naftopidil improves locomotor activity and urinary frequency in rats with pelvic venous </b><b>congestion </b>

Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats

Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats

Contact Info

Product

Resources

About