The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology

DeVallance, Evan; Li, Yao; Jurczak, Michael J.; Cifuentes-Pagano, Eugenia; Pagano, Patrick J.

doi:10.1089/ars.2018.7674

Cited by 60 publications

(79 citation statements)

References 228 publications

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“…Studying SNPs in oxidative stress‐related genes is a useful method to determine the genetic predisposition of patients to oxidative stress and clarify the pathogenesis of disease. MPO and NADPH oxidase catalyse the generation of HOCl and O 2 •‐ , promote the formation of various reactive oxygen and nitrogen species and play important roles in the pathogenesis of diseases 7,8,15 …”

Section: Discussionmentioning

confidence: 99%

“…The NADPH oxidase (NOX) family of enzymes is a major driver of redox signalling through the production of superoxide anion (O 2 •‐ ), H 2 O 2 and downstream metabolites, and these enzymes play key roles in physiological redox homeostasis and the occurrence of several diseases 15 . The p22phox subunit, a transmembrane protein encoded by the CYBA gene, is a major component of NOX complexes 15 . The C242T (rs4673) SNP, which is located in exon 4 of the CYBA gene, encodes a CAC → TAC codon change, leading to a nonconservative substitution, His72Tyr 16 .…”

Section: Introductionmentioning

confidence: 99%

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Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome

Liu

et al. 2020

Eur J Clin Investigation

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Background Oxidative stress plays a pivotal role in the pathogenesis of polycystic ovary syndrome (PCOS). Genetic variations in myeloperoxidase (MPO; G‐463A) and NADPH oxidase p22phox subunit (CYBA; C242T) cause inter‐individual variability in enzyme activities. Here, we investigated the associations between MPO activity and the MPO G‐463A and CYBA C242T polymorphisms in Chinese women with PCOS. Methods This case‐control study included 1003 patients with PCOS and 810 controls. The G‐463A and C242T polymorphisms were detected by polymerase chain reaction and restriction analysis, and clinical, hormonal, metabolic and oxidative stress parameters and MPO activity were analysed. Results The frequencies of the GA + AA genotype and A allele frequency of the MPO G‐463A polymorphism were significantly higher in the PCOS group than in the control group. Logistic regression analysis showed that the MPO‐463A allele is a risk factor for PCOS (OR = 1.261, 95% CI: 1.042‐1.526, P = .017). Patients with the AA genotype tended to have higher plasma MPO activity than those with the GG genotype. No statistical significance was found in the genotype and allele frequencies of the CYBA C242T polymorphism between the PCOS and control groups. However, we demonstrated that the coexistence of the MPO A allele (GA + AA genotypes) and the CYBA CC genotype was associated with an increased risk of PCOS when compared with the wild‐type GG/CC genotypes (OR = 1.302, 95% CI: 1.030‐1.646, P = .027). Conclusion The MPO G‐463A variant, but not CYBA C242T variant, is associated with a risk of PCOS in Chinese women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome

Liu

et al. 2020

Eur J Clin Investigation

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“…lead to inflammation and development of pathological conditions (DeVallance et al, 2019). Is has been proposed that ROS derived by NOX4, the major adipocyte isoform of NADPH oxidase, may play a role in the onset of insulin resistance and adipose tissue inflammation during the development of obesity in mice fed a high-fat, high-sucrose diet (Den Hartigh et al, 2017).…”

Section: Nox Activation Is a Common Hallmark Of Main Comorbidities Asmentioning

confidence: 99%

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Damiano

Sozio

Rosa

et al. 2020

Front. Cell. Infect. Microbiol.

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“…In fact, obesity induces oxidative stress as a consequence of an imbalance in the redox system due to the excess of free radicals, reactive oxygen species (ROS), and/or antioxidant disruption (Schieber & Chandel, ). The possible contributors to increased ROS in obesity include hyperglycemia (Aronson & Rayfield, ), high accumulation of ectopic fat (Beltowski, Wojcicka, Gorny, & Marciniak, ), vitamin and mineral deficiencies (Ortega et al, ), chronic inflammation (Fernandez‐Sanchez et al, ), hyperleptinemia (Bouloumie, Marumo, Lafontan, & Busse, ), impairment of mitochondrial function (Pennathur & Heinecke, ), and increased of the NADPH oxidase pathway (DeVallance, Li, Jurczak, Cifuentes‐Pagano, & Pagano, ). In addition, endogenous and exogenous antioxidant compounds are inversely related to body fat and visceral obesity and induce cell damage in obese individuals (Chrysohoou et al, ).…”

Section: Obesity and Its Effectsmentioning

confidence: 99%

Ginger and avocado as nutraceuticals for obesity and its comorbidities

Tramontin

Luciano

Marques

et al. 2020

Phytotherapy Research

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Obesity is a worldwide epidemic and is one of the factors involved in the etiology of type 2 diabetes mellitus. Obesity induces low-grade inflammation and oxidative stress. The treatment for obesity involves changes in diet, physical activity, and even medication and surgery. Currently, the use of nutraceutical compounds is associated with health benefits. Ginger and avocado are used for many people all around the world; however, its effect as a nutraceutical compound is less known by the general population. For this reason, we searched information of the literature to point its effects on distinct mechanisms of defense against the obesity its comorbidities. The present review aimed showing that these nutraceuticals may be useful in obesity treatment. Reports have shown that ginger and avocado induce antioxidant and antiinflammatory effects by improving enzymatic activity and modulating obesity-related impairments in the anti-inflammatory system in different tissues, without side effects.Furthermore, ginger and avocado were found to be effective in reversing the harmful effects of obesity on blood lipids. In conclusion, on the basis of the positive effects of ginger and avocado in in vitro, animal, and human studies, these nutraceuticals may be useful in obesity treatment. K E Y W O R D Sdiabetes treatment, inflammation, obesity, oxidative stress, phytotherapeutic approach, unhealthy diet

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The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology

Cited by 60 publications

References 228 publications

Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome

Myeloperoxidase andCYBAgenetic variants in polycystic ovary syndrome

NOX-Dependent Signaling Dysregulation in Severe COVID-19: Clues to Effective Treatments

Ginger and avocado as nutraceuticals for obesity and its comorbidities

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