The role of N6-methyladenosine modification in rodent models of neuropathic pain: from the mechanism to therapeutic potential

Wu, Liping; Tang, Hongliang

doi:10.1016/j.biopha.2023.115398

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2024

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“…Recognition of m 6 A by the “reader” RBPs YTHDF1/2/3 imparts changes in mRNA expression, processing, localization, translation, and decay. The role of m 6 A was the subject of two recent reviews (Albik & Tao, 2021; Wu & Tang, 2023). Below we provide a brief overview of key findings in the field, but refer readers to these excellent reviews for a comprehensive discussion of m 6 A and pain.…”

Section: Main Textmentioning

confidence: 99%

RNA‐binding proteins in pain

Smith,

Campbell

2024

WIREs RNA

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RNAs are meticulously controlled by proteins. Through direct and indirect associations, every facet in the brief life of an mRNA is subject to regulation. RNA‐binding proteins (RBPs) permeate biology. Here, we focus on their roles in pain. Chronic pain is among the largest challenges facing medicine and requires new strategies. Mounting pharmacologic and genetic evidence obtained in pre‐clinical models suggests fundamental roles for a broad array of RBPs. We describe their diverse roles that span RNA modification, splicing, stability, translation, and decay. Finally, we highlight opportunities to expand our understanding of regulatory interactions that contribute to pain signaling.This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications Translation > Regulation RNA in Disease and Development > RNA in Disease

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Section: Main Textmentioning

confidence: 99%