The role of N6-methyladenosine (m6A) in eye diseases

IGF2BP2 Maintains Retinal Pigment Epithelium Homeostasis by Stabilizing PAX6 and OTX2

“…Research into the m 6 A readers, including the YTHDF family and YTHDC2, highlights their diverse and significant impacts on eye-related pathologies and RNA dynamics. 26 YTHDF2 has been implicated in RNA degradation and is associated with the regulation of corneal neovascularization. 26 , 57 YTHDF1/3 has been suggested to play a role in enhanced translation, and YTHDF1, specifically, may play a role in ocular melanoma and oxygen-induced retinopathy.…”

“… 26 YTHDF2 has been implicated in RNA degradation and is associated with the regulation of corneal neovascularization. 26 , 57 YTHDF1/3 has been suggested to play a role in enhanced translation, and YTHDF1, specifically, may play a role in ocular melanoma and oxygen-induced retinopathy. 58 , 59 YTHDC1 is primarily involved in regulating pre-mRNA splicing and facilitating mRNA nuclear transport, whereas YTHDC2 contributes to mRNA stability and translation.…”

“… 23 Mounting evidence suggests the involvement of m 6 A modifications and their modulators in AMD pathogenesis. 24 – 26 However, there is a lack of studies on the regulation of RPE cell characteristics by m 6 A modification.…”

Biomaterials‐Based Cell Therapy for Myocardial Tissue Regeneration

“…[2,56,75,8,99] Stem cell-derived CMs have emerged as one of the most attractive cellular sources for the rescue of damaged cardiac tissue based on cell therapy, e.g., mouse and human iPS-derived functional CMs, [29,86,100] Gao et al proposed a protocol for the preparation of human cardiac patches (hCMPs), which consisted of derivatizing hiPS into CMs, ECs, and smooth muscle cells, respectively, and mixed them to form hCMPs. [58] In a guinea pig MI model, implantation of an hiPS-derived engineered heart tissue patch showed muscularization of scarring, improvement in left ventricular ejection fraction (LVEF), and reduction in left ventricular end-diastolic diameter. [57] In one study, Chow et al [31] loaded iPSC-derived CMs onto polyethylene glycol (PEG) hydrogel and injected them into MI rats to evaluate their therapeutic effect.…”

“…[56] The field of regenerative medicine has proposed strategies for biomimetic carriers. To date, there are many forms of cell carriers, including patches, [7,36,57,58] particles, [49,[59][60][61] hydrogels, [62][63][64][65] electro-discharge nanofibers, [21,33,[66][67][68] sprays, [6] etc. On the one hand, the delivery of cells through biomaterial carriers can reduce microenvironmental shocks and promote cell survival and retention.…”