The Role of Multimodality Imaging in the Diagnosis and Follow-Up of Malignant Primary Cardiac Tumors: Myxofibrosarcoma—A Case Report and Literature Review

Șerban, Adela; Dădârlat-Pop, Alexandra; Tomoaia, Raluca; Trifan, Catalin; Molnar, Adrian; Manole, Simona; Achim, Alexandru; Suceveanu, Mihai

doi:10.3390/diagnostics13101811

Cited by 3 publications

(8 citation statements)

References 21 publications

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“…9 Although the majority of primary cardiac tumors are benign, 10 Early diagnosis and prompt treatment are crucial for enhancing patient survival in cases of malignancies, particularly in the context of MFS, because due to the absence of hallmark symptoms during the initial disease stages, these conditions are associated with a poor prognosis. 11 Given the heterogeneous spectrum of cardiac masses, ranging from clots or vegetations to primary or metastatic malignancies, a consensus on the optimal diagnostic approach has yet to be established. 12 According to an article by Lemasle et al, the current Cardiac imaging modalities are transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), cardiac magnetic resonance (cMR), cardiac computed tomography (CT), and 18Ffluorodeoxyglucose positron emission tomography (18F FDG-PET).…”

Section: Discussionmentioning

confidence: 99%

“…Although the majority of primary cardiac tumors are benign, 10 Early diagnosis and prompt treatment are crucial for enhancing patient survival in cases of malignancies, particularly in the context of MFS, because due to the absence of hallmark symptoms during the initial disease stages, these conditions are associated with a poor prognosis. 11 …”

Section: Discussionmentioning

confidence: 99%

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A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review

Soltani,

Garousi,

Mirzaee

et al. 2024

Cancer Reports

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BackgroundPrimary cardiac myxofibrosarcoma is a rare and aggressive malignancy, with the majority of approaching strategies relying on case reports. This article provides insights into its diagnosis and treatment.Case PresentationThis paper presents the case of a 40‐year‐old man with sudden onset hemoptysis, leading to the diagnosis of primary cardiac myxofibrosarcoma. Treatment involved open‐heart surgery to excise the left atrium tumor, followed by 6 cycles of adjuvant chemotherapy. Unfortunately, brain metastasis developed, leading to the patient's death 1 year after initial diagnosis.ConclusionPrimary cardiac myxofibrosarcoma remains a clinical challenge with an unfavorable prognosis. Early diagnosis through advanced imaging is crucial, and research is needed to explore innovative treatments. This case underscores the complexities of managing this rare cardiac malignancy and highlights the necessity for ongoing investigations to enhance patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review

Soltani,

Garousi,

Mirzaee

et al. 2024

Cancer Reports

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“…Multimodality imaging facilitates the differential diagnosis of right cardiac tumors [4]. Some authors consider that, when available, all imaging methods should be used, especially in certain cardiac tumors like myxofibrosarcoma [7,10].…”

Section: Imaging Modalities For Assessing Right Heart Tumorsmentioning

confidence: 99%

“…Two-dimensional transthoracic echocardiography is the first-line non-invasive imaging modality used in the evaluation of heart tumors. It detects cardiac tumors with 90% sensitivity and 95% specificity [7,11].…”

Section: Echocardiographymentioning

confidence: 99%

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Multimodality Imaging in Right Heart Tumors: Proposed Algorithm towards an Appropriate Diagnosis

Floria,

Burlacu,

Morariu

et al. 2024

JCM

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A right heart tumor can be identified by transthoracic echocardiography during a routine examination or due to cardiac symptoms. The first step is the assessment by echocardiography, with its multiple techniques, and the obtained information must be judged in a clinical and biological context. The second step comprises one, sometimes even two, of the more complex modality imaging methods. The choice is driven not only by the advantages of each imaging technique but also by local expertise or the preferred imaging modality in the center. This step is followed by staging, follow-up, and/or imaging-guided excision or biopsy, which is performed in selected cases in order to obtain anatomopathological confirmation. In the presence of features suggestive of malignancy or causing hemodynamic impairment, a transvenous biopsy is essential before the more complex imaging modalities (which are still relevant in the staging process). Using a structured imaging approach, it is possible to reach an appropriate diagnosis without a biopsy. Frequently, these imaging techniques have a complementary role, so an integrated imaging approach is recommended. This proposed algorithm for appropriate diagnosis of right heart tumors could serve as a practical guide for clinicians (not only imaging specialists).

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Multimodality Imaging in Right Heart Tumors: A Practical Algorithm towards an Appropriate Diagnosis

Floria,

Burlacu,

Morariu

et al. 2024

Preprint

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Right heart masses are usually suspected during a routine examination by transthoracic echocardiography or due to cardiac symptoms. Although very important, sometimes it may be a challenge to differentiate between normal structures (variants) and aberrant or pathologic masses regarding the right heart cardiac tumors. In the last entity, the majority of primary cardiac tumors in adults and children are benign; however, they may have a malignant counterpart. Right heart tumors might involve not only the walls (myocardium, endocardium and pericardium), but also valves and cardiac chambers. Cardiac tumors exhibit altered signal intensity and enhancement characteristics, requiring the use of several imaging methods following a multimodality-imaging algorithm that culminates in the excision or biopsy of the tumor formation. Therefore, various imaging modalities, including echocardiography, computer tomography, positron emission tomography, cardiac magnetic resonance imaging, scintigraphy or, even, invasive angiography, can be useful during their diagnosis. Echocardiography is the first-line non-invasive imaging modality used in the evaluation of the right heart tumors. Before the other diagnosis imaging modalities it is essential for defining morphology, assessing size, observing dynamic appearance, and evaluating functional abnormalities and hemodynamic consequences,. However, all imaging methods have frequently a complementary role; therefore, an integrated imaging approach is recommended.

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The Role of Multimodality Imaging in the Diagnosis and Follow-Up of Malignant Primary Cardiac Tumors: Myxofibrosarcoma—A Case Report and Literature Review

Cited by 3 publications

References 21 publications

A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review

A rare presentation of primary cardiac myxofibrosarcoma: Case report and literature review

Multimodality Imaging in Right Heart Tumors: Proposed Algorithm towards an Appropriate Diagnosis

Multimodality Imaging in Right Heart Tumors: A Practical Algorithm towards an Appropriate Diagnosis

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