The Role of Multimodality Cardiac Imaging in the Transplanted Heart

Estep, Jerry D.; Shah, Dipan J.; Nagueh, Sherif F.; Mahmarian, John J.; Torre‐Amione, Guillermo; Zoghbi, William A.

doi:10.1016/j.jcmg.2009.06.006

Cited by 53 publications

(35 citation statements)

References 60 publications

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“…5 ). Left ventricular (LV) ejection fraction (LV EF) is a traditionally used marker of systolic performance based on volume analyses and thus may not reveal subtle changes in contractility.…”

Section: Introductionmentioning

confidence: 99%

Decrease in longitudinal strain in heart transplant recipients is associated with rejection

Podroužková¹,

Bedáňová²,

Třetina³

et al. 2015

BIOMED PAP

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Background. Around 20-40% of heart transplant patients experience moderate to severe rejection within the first year after heart transplantation. Endomyocardial biopsy (EMB) is a gold standard for diagnosing heart transplant rejection. There is a need for non-invasive alternatives that allow for early, safe and reliable diagnosis of acute graft rejection prior to the onset of clinical symptoms. Aims. Our aim was to investigate the potential of speckle tracking derived strain analysis in the diagnosis of acute graft rejection. Methods. Patients indicated for EMB consented to a trans-thoracic echocardiography examination (TTE) within 2 hours of the EMB. Of this cohort, those with at least 2 EMBs separated ≥ 1 week, and whose TTE could be analyzed for strain, were included. The relationship between strain and EMB results was evaluated. Results. Of the 43 patients included (mean age 51.33±1.79, 67% male), 23 had findings of rejection identified on at least one EMB and at least one EMB without rejection for comparison. A significant deterioration in the longitudinal strain during rejection compared to non-rejection was found on apical 4-chamber views (-11.51±0.91 vs -13.48±0.96, P=0.025) and apical 2-chamber views (-11.84±0.78 vs -14.43±0.83, P=0.002). In the patients in whom no rejection was identified on either EBM, there was no significant change in longitudinal strain values at two different time points. Conclusion. Worsening of longitudinal strain was associated with acute cellular rejection. Routine TTE-based strain analysis could help in early detection of cardiac rejection and timing of EMB.

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Section: Introductionmentioning

confidence: 99%

Decrease in longitudinal strain in heart transplant recipients is associated with rejection

Podroužková¹,

Bedáňová²,

Třetina³

et al. 2015

BIOMED PAP

View full text Add to dashboard Cite

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“…Literatürde BT koroner anjiyografinin, koroner arter hastalığı tanısında konvansiyel anjiyografiye yakın, hatta eşit sonuçlar verdiği bildirilmiştir. [1][2][3][4][5] Biz de nakil hastalarında koroner allogreft vaskülopatinin tespiti ve takibi için BT koroner anjiyografinin güve-nilirliğini klasik koroner anjiyografi ile karşılaştırarak araştırdık.…”

Section: Discussionunclassified

“…Çok kesitli BT, lümene ek olarak koroner duvarı da gös-terebildiği için, ekokardiyografi, miyokard perfüzyon görüntülemesi ve MR'ye göre allogreft vaskülopatisini daha erken saptama potansiyeline sahiptir. [5] Kalp nakli yapılan hastaların bir yıllık yaşam oranı %80-90 arasında bildirilmiştir. [6] Ancak uzun dönem yaşam oranları halen sıkıntılıdır.…”

Section: Discussionunclassified

Evaluation of allograft vasculopathy by computed tomography coronary angiography in cardiac transplant recipients

Küçüker¹

2013

Turk Gogus Kalp Dama

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Amaç: Bu çalışmada kalp nakli yapılmış hastalarda bilgisayarlı tomografi (BT) koroner anjiyografinin allogreft vaskü-lopati tanısındaki etkinliği araştırıldı.Ça lış m apla nı:Kalp nakli sonrası iki yılını doldurmuş ve son üç ay içerisinde kontrol koroner anjiyografisi yapıl-mış 10 hasta (9 erkek, 1 kadın; ort. yaş 41±9.2 yıl; dağılım 17-59 yıl) çalışmaya alındı. Bu hastalara BT koroner anjiyografi yapıldı. Tüm hastaların standart anjiyografileri aynı araştırmacı tarafından değerlendirildi. Ardından BT koroner anjiyogramlar, bu değerlendirmelerden habersiz ikinci bir araştırmacı tarafından değerlendirdi. Her iki değerlendirme sonucu, üçüncü bir araştırmacı tarafından karşılaştırıldı. Bul gu lar:Bilgisayarlı tomografi koroner anjiyografide sekiz hastada önemli bir patoloji gözlenmezken, iki hastada sol ön inen koroner arterde yaklaşık %50'lik darlık saptadı. Standart koroner anjiyografide de aynı hastalarda aynı yerleşimde ve benzer oranda sol ön inen koroner arter lezyonları saptandı. Tüm hastalarda standart koroner anjiyografi ve BT koroner anjiyografi sonuçları birbiriyle uyumluydu.So nuç: Bilgisayarlı tomografi koroner anjiyografi daha az invaziv olup, hasta için daha az risk taşımaktadır. Uygulama kolaylığı ve etkin maliyet gibi bazı avantajlara da sahiptir. Hastaneye yatış gerektirmez. Kalp nakli alıcılarında koroner allogreft vaskülopatinin rutin takibinde BT koroner anjiyografi, standart koroner anjiyografiye alternatif olarak kullanı-labilir.Anah tar söz cük ler: Allogreft vaskülopati; kalp nakli; bilgisayarlı tomografi koroner anjiyografi.Background: This study aims to investigate the efficacy of computed tomography (CT) coronary angiography for the diagnosis of allograft vasculopathy.

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“…CMR can be used for the identification of systolic dysfunction and myocardial edema in cardiac transplant recipients allowing early detection of cardiac rejection [73]. Moreover, LGE-CMR is useful indirectly in the detection of cardiac allograft vasculopathy based on the ability to detect silent myocardial infarctions.…”

Section: Cmr In the Transplanted Heartmentioning

confidence: 99%

Cardiovascular Magnetic Resonance in Heart Failure

Karamitsos

Neubauer

2011

Curr Cardiol Rep

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Imaging has a central role in the evaluation of patients with heart failure (HF). Cardiovascular magnetic resonance (CMR) is rapidly evolving as a versatile imaging modality that often provides additional information to echocardiography in patients with suspected or known HF. CMR is the only imaging modality that has the ability to assess, without exposure to ionizing radiation, cardiac function, structure (tissue characterization), perfusion, and viability. Moreover, magnetic resonance spectroscopy techniques can assess the pathophysiologic role of deranged cardiac energetics in HF. In this review we discuss the role of CMR in the evaluation of patients with HF giving particular emphasis to recent developments and the additional information that can be obtained with this imaging modality, over and above standard echocardiography.

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The Role of Multimodality Cardiac Imaging in the Transplanted Heart

Cited by 53 publications

References 60 publications

Decrease in longitudinal strain in heart transplant recipients is associated with rejection

Decrease in longitudinal strain in heart transplant recipients is associated with rejection

Evaluation of allograft vasculopathy by computed tomography coronary angiography in cardiac transplant recipients

Cardiovascular Magnetic Resonance in Heart Failure

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