The role of mucins in gastrointestinal barrier function during health and disease

Breugelmans, Tom; Oosterlinck, Baptiste; Arras, Wout; Ceuleers, Hannah; Man, Joris De; Hold, Georgina L.; Winter, Benedicte Y. De; Smet, Annemieke

doi:10.1016/s2468-1253(21)00431-3

Cited by 43 publications

(44 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, both 25(OH)VD 3 and VD 3 increased the mRNA expression of tight junction proteins, resulting in an improved intestinal barrier function in the weaned piglets. Many studies have reported that the down-regulation of ZO-1, Occludin and Claudin-1 expression would increase intestinal permeability and lead to intestinal-related diseases [ 52 , 53 , 54 ]. The intestinal mucosal defense was conducted by the tight junction expression of the intestinal epithelia along with defensins and lysozymes secreted by the Paneth cells, which could be promoted by dietary VD 3 supplementation [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of 25-Hydroxyvitamin D3 Improves Growth Performance, Antioxidant Capacity and Immune Function in Weaned Piglets

Zhou

Zou

et al. 2022

Antioxidants

View full text Add to dashboard Cite

This study was conducted to evaluate the effects of 25-hydroxyvitamin D3 (25(OH)VD3) and Vitamin D3 (VD3) supplemented in the diet of weaned piglets on their growth performance, bone quality, intestinal integrity, immune function and antioxidant capacity. A total of 192 weaned piglets were allocated into four groups and they were fed a control diet containing 2000 IU VD3 (negative control, NC), NC + 100 ppm colistin sulfate (positive control, PC), NC + 2000 IU VD3 (VD3) and NC + 2000 IU 25(OH)VD3 (25(OH)VD3). The results showed that 25(OH)VD3 improved the growth performance, bone quality and antioxidase activity of piglets compared with the other groups. Meanwhile, 25(OH)VD3 up-regulated ileal mRNA expressions of tight junction proteins and host defense peptides. The VD3 group had an increased intestinal sIgA content and mRNA expression of pBD-1 compared with the NC group. Both groups of VD3 and 25(OH)VD3 altered the microbial β-diversity compared with the NC group, and 25(OH)VD3 increased ileal concentrations of acetate and butyrate. In conclusion, our findings indicated that a regular dosage of 2000 IU VD3 in the weaned piglets’ diet did not achieve optimal antioxidant capacity and immune function. 25(OH)VD3 had better growth performance than VD3 at the same inclusion level, which is associated with the improved intestinal integrity and antioxidant capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary Supplementation of 25-Hydroxyvitamin D3 Improves Growth Performance, Antioxidant Capacity and Immune Function in Weaned Piglets

Zhou

Zou

et al. 2022

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Regardless, improper MUC1, MUC4, and MUC13 expression leads to abnormalities of the epithelial-mesenchymal transition (EMT) signaling pathways in the gastrointestinal tract as well as the mechanism by which aberrant catenin, ZEB1, ERK, and ERBB activation causes metastatic development. Thus, the disturbed interplay between TJ and cancer cells facilitates the motility and invasion of tumorigenic cells [ 193 ]. Despite extensive investigation, no conclusive agreement has been established on the function of signaling competent mucin, identified as a fundamental driver of cell proliferation, growth, and survival [ 194 ].…”

Section: Mucus Abnormalities and Diseasementioning

confidence: 99%

View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus

Gao

Xin

et al. 2023

IJMS

View full text Add to dashboard Cite

Due to mucin’s important protective effect on epithelial tissue, it has garnered extensive attention. The role played by mucus in the digestive tract is undeniable. On the one hand, mucus forms “biofilm” structures that insulate harmful substances from direct contact with epithelial cells. On the other hand, a variety of immune molecules in mucus play a crucial role in the immune regulation of the digestive tract. Due to the enormous number of microorganisms in the gut, the biological properties of mucus and its protective actions are more complicated. Numerous pieces of research have hinted that the aberrant expression of intestinal mucus is closely related to impaired intestinal function. Therefore, this purposeful review aims to provide the highlights of the biological characteristics and functional categorization of mucus synthesis and secretion. In addition, we highlight a variety of the regulatory factors for mucus. Most importantly, we also summarize some of the changes and possible molecular mechanisms of mucus during certain disease processes. All these are beneficial to clinical practice, diagnosis, and treatment and can provide some potential theoretical bases. Admittedly, there are still some deficiencies or contradictory results in the current research on mucus, but none of this diminishes the importance of mucus in protective impacts.

show abstract

“…The gut microbiota in healthy people can influence intestinal epithelial cells to prevent the destruction of intestinal mucosa [ 50 , 51 ]. It was found that butyrate derived from gut microbiota can regulate the repair of intestinal mucus barrier by activating the macrophage/wingless and int-1 (Wnt)/extracellular regulated protein kinase (ERK) signaling pathways which effectively separating the body from intestinal pathogens [ 52 ].…”

Section: The Role Of the Gut Microbiota In Health And Diseasesmentioning

confidence: 99%

The role of the gut microbiota in health and cardiovascular diseases

Wang

Zhang

et al. 2022

Mol Biomed

View full text Add to dashboard Cite

The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, and producing metabolites to interact with the host. Meanwhile, increasing evidence indicates that the gut microbiota has a strong correlation with the occurrence, progression and treatment of cardiovascular diseases (CVDs). In patients with CVDs and corresponding risk factors, the composition and ratio of gut microbiota have significant differences compared with their healthy counterparts. Therefore, gut microbiota dysbiosis, gut microbiota-generated metabolites, and the related signaling pathway may serve as explanations for some of the mechanisms about the occurrence and development of CVDs. Several studies have also demonstrated that many traditional and latest therapeutic treatments of CVDs are associated with the gut microbiota and its generated metabolites and related signaling pathways. Given that information, we summarized the latest advances in the current research regarding the effect of gut microbiota on health, the main cardiovascular risk factors, and CVDs, highlighted the roles and mechanisms of several metabolites, and introduced corresponding promising treatments for CVDs regarding the gut microbiota. Therefore, this review mainly focuses on exploring the role of gut microbiota related metabolites and their therapeutic potential in CVDs, which may eventually provide better solutions in the development of therapeutic treatment as well as the prevention of CVDs.

show abstract

The role of mucins in gastrointestinal barrier function during health and disease

Cited by 43 publications

References 96 publications

Dietary Supplementation of 25-Hydroxyvitamin D3 Improves Growth Performance, Antioxidant Capacity and Immune Function in Weaned Piglets

Dietary Supplementation of 25-Hydroxyvitamin D3 Improves Growth Performance, Antioxidant Capacity and Immune Function in Weaned Piglets

View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus

The role of the gut microbiota in health and cardiovascular diseases

Contact Info

Product

Resources

About