The Role of mTOR, Autophagy, Apoptosis, and Oxidative Stress During Toxic Metal Injury

Chatterjee, Sarmishtha; Munshi, Chayan; Bhattacharya, Shelley

doi:10.1016/b978-0-12-802733-2.00013-x

Cited by 3 publications

(2 citation statements)

References 154 publications

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“…A autofagia celular é um processo homeostático que desempenha papel fundamental na defesa do hospedeiro de patógenos invasores pela digestão do conteúdo plasmático celular por lisossomos e na manutenção da homeostase celular (85,87,88). É um mecanismo envolvido na eliminação de microrganismos, apresentação de antígenos, controle da sinalização pró-inflamatória e secreção de mediadores imunes ou expulsão de partículas virais (26,57,84,85,87). Quando uma célula está necessitando de nutrientes, em parte como consequência de estresse ou infecção viral, iniciam-se processos catabólicos para reciclar componentes intracelulares e gerar energia por vias alternativas (84).…”

Section: Figura 15 Cinética Da Infecção Por Orov Em Células Vero E6 A...unclassified

“…É um mecanismo envolvido na eliminação de microrganismos, apresentação de antígenos, controle da sinalização pró-inflamatória e secreção de mediadores imunes ou expulsão de partículas virais (26,57,84,85,87). Quando uma célula está necessitando de nutrientes, em parte como consequência de estresse ou infecção viral, iniciam-se processos catabólicos para reciclar componentes intracelulares e gerar energia por vias alternativas (84). Isso ocorre tanto pela degradação direta do patógeno quanto pela interface indireta com o sistema imunológico inato e adaptativo, envolvendo a apresentação de antígenos, eliminação…”

Section: Figura 15 Cinética Da Infecção Por Orov Em Células Vero E6 A...unclassified

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Avaliação de potenciais biomarcadores envolvidos no mecanismo de infecção do vírus Oropouche por metabolômica

Cristina Mor

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Oropouche virus (OROV) is an emerging arbovirus that causes acute febrile illness in humans in tropical areas of Central and South America. In Brazil, it is responsible for about half a million cases since its discovery. It is considered one of the most prevalent arboviruses in the Northern region of Brazil affecting mainly cities and villages in the Amazon and Central regions of the country. It is an RNA virus transmitted to humans through mosquito bites, mainly Culicoides paraenses, which transmits the so-called Oropouche fever, clinical manifestations similar to other frequent arboviruses such as Dengue, Chikungunya fever, and Zika virus disease. Despite its considerable presence in the Brazilian territory, the actual incidence of OROV infection can be masked by other arboviruses due to the similarity of symptoms, which leads to underreporting of cases, omission of potential disease-specific clinical aggravations, and makes specialized treatment difficult. At present, there are no specific therapeutic or preventive approaches to combat the virus, besides there is few data on its pathogenicity. Moreover, its vector has a wide geographic distribution in South and Central America, which makes evident the considerable risk of OROV dissemination and the emergence of a major public health problem similar to what happened with Chikungunya in 2014 and also with Zika in 2016. The study and understanding of morphological and metabolic alterations, including the identification of potential biomarkers in infected C6/36 and Vero cells and possible mechanisms associated with OROV infection in these cell lines by high-resolution electrospray ionization mass spectrometry (ESI-HRMS) suggests that OROV infection induces morphological and metabolomic alterations in both mosquito and mammalian cells, mainly associated with intravesicular trafficking and lipid synthesis. This information can contribute to the establishment of new targets for viral control and also to the development of a specific diagnosis.

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Section: Figura 15 Cinética Da Infecção Por Orov Em Células Vero E6 A...unclassified

Avaliação de potenciais biomarcadores envolvidos no mecanismo de infecção do vírus Oropouche por metabolômica

Cristina Mor

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Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death

Vongthip,

Nilkhet,

Boonruang

et al. 2024

Sci Rep

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Neurodegenerative diseases, characterized by progressive neuronal dysfunction and loss, pose significant health challenges. Glutamate accumulation contributes to neuronal cell death in diseases such as Alzheimer's disease. This study investigates the neuroprotective potential of Albizia lebbeck leaf extract and its major constituent, luteolin, against glutamate-induced hippocampal neuronal cell death. Glutamate-treated HT-22 cells exhibited reduced viability, altered morphology, increased ROS, and apoptosis, which were attenuated by pre-treatment with A. lebbeck extract and luteolin. Luteolin also restored mitochondrial function, decreased mitochondrial superoxide, and preserved mitochondrial morphology. Notably, we first found that luteolin inhibited the excessive process of mitophagy via the inactivation of BNIP3L/NIX and inhibited lysosomal activity. Our study suggests that glutamate-induced autophagy-mediated cell death is attenuated by luteolin via activation of mTORC1. These findings highlight the potential of A. lebbeck as a neuroprotective agent, with luteolin inhibiting glutamate-induced neurotoxicity by regulating autophagy and mitochondrial dynamics.

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A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer

VOON

Gazali

Zamri

et al. 2022

J. Comput. Biophys. Chem.

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Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on [Formula: see text]-unsaturated carbonyl molecules. Structural modifications to [Formula: see text]-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic [Formula: see text]-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies.

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The Role of mTOR, Autophagy, Apoptosis, and Oxidative Stress During Toxic Metal Injury

Cited by 3 publications

References 154 publications

Avaliação de potenciais biomarcadores envolvidos no mecanismo de infecção do vírus Oropouche por metabolômica

Avaliação de potenciais biomarcadores envolvidos no mecanismo de infecção do vírus Oropouche por metabolômica

Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death

A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer

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