1997
DOI: 10.1002/(sici)1096-9896(199705)182:1<106::aid-path816>3.3.co;2-1
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The Role of Monocyte Chemoattractant Protein‐1 (Mcp‐1) in the Pathogenesis of Collagen‐induced Arthritis in Rats

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Cited by 25 publications
(32 citation statements)
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“…The role of MCP-1 in an inflamed RA joint may be the recruitment of mononuclear phagocytes. And in fact, the effectiveness of anti-MCP-1 antibody treatments against arthritis development has been reported in some arthritis models [32,33]. In our study, IL-1β and MCP-1 mRNA expression were markedly increased in the arthritis group compared to the control group.…”
Section: Discussionsupporting
confidence: 49%
“…The role of MCP-1 in an inflamed RA joint may be the recruitment of mononuclear phagocytes. And in fact, the effectiveness of anti-MCP-1 antibody treatments against arthritis development has been reported in some arthritis models [32,33]. In our study, IL-1β and MCP-1 mRNA expression were markedly increased in the arthritis group compared to the control group.…”
Section: Discussionsupporting
confidence: 49%
“…In the present study, we con®rm the increased production of MCP-1 and RANTES in rats with adjuvantinduced arthritis, in congruence with previous reports [15,16,17,18] and show that their enhanced production as well as the progression of arthritis are suppressed by treatment with KE-298. We also demonstrate that KE-298 suppresses MCP-1 and RANTES production by IL1b-stimulated RA synoviocytes, although MIP-1a in the supernatant of these synoviocytes was not reduced during treatment with KE-298 (data not shown).…”
Section: Discussionsupporting
confidence: 93%
“…Furthermore, excessive production of MCP-1 and RANTES by synoviocytes has been demonstrated in RA [10,11,12,13,14]. Both MCP-1 and RANTES have also been suggested to play important roles in the pathogenesis of arthritis in animal models including adjuvant-induced arthritis in rats, and treatment with an antagonist of these chemokines has signi®cantly suppressed the progression of arthritis in RA animal models [15,16,17,18].…”
Section: Introductionmentioning
confidence: 99%
“…In AIA, anti-TNF␣ antibody treatment improved clinical scores and decreased leukocyte infiltration into the synovium (32). Both anti-MIP-1␣ and anti-MCP-1 antibodies have been tried successfully in CIA (4,49,55). In our recent study, an antibody to ENA-78 administered prior to the onset of AIA could prevent the development of arthritis.…”
Section: Discussionmentioning
confidence: 91%