The Role of Mofs in Outcome in Patients With Septic Shock

Abstract

BACKGROUND Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. Infections are the primary outcome determinant of the MOFS in patients with septic shock. This is a prospective study conducted in DMC and H over a period of 15 months, where patients admitted to all kinds of Medicine Department ICU's were studied. The objective of this study is to provide data from our college to study the incidence of MOFS in septic shock patients, number of organs involvement and its influence on mortality. MATERIALS AND METHODS A total of 104 patients were enrolled in the study. Patients were enrolled as per inclusion criteria for septic shock. Out of total 104 patients, 64 patients (61.54%) had MOFS and 40 patients (38.46%) were without MOFS. Out of 64 patients with MOFS, 18 patients had single organ involvement with mortality rate of 11.11%, 12 patients had 2-3 organs involvement, mortality rate of 33.33% and 34 patients were having more than 3 organs involvement with highest mortality rate of 70.58%. UTI was found to be a major source of infection in 60.58% of patients. RESULTS The baseline demographic characteristics and various parameters of recovery of patients were evaluated and noted. Maximum number of patients, 29 (27.88%) were in the age group of 56-65 years followed by age group 46-55 years (22.12%). CONCLUSION So we conclude that MOF due to sepsis in an ICU is frequent with high mortality related to the number of failing organs, age and high APACHE II.

Latitudinal distribution of onygenales and related hyphomycetes in soils of northern chile between 18-34° south latitude

“…In brackets "density of isolates by plates". The relationship between the human-animal presence in the environment and the distribution of keratinophilic fungi in soils has been demonstrated by many papers (11, 23, 25, 26, 27, 28, 29, 30, 36, 39 52) in different latitudes (mostly in the norther~ hemisphere), generally in direct relation to the quantity and quality of the prevailing organic matter (46), mainly supplied by the vegetable cover, the humus content, the presence of fatty acids ( 45) as well as the keratinic material ( 43) or other cm;npon~nt?. ~owever ~ue to the wide geographical dtstnbutlon of tbetr numerous taxa and tbeir ability to metabolize as saprotrophic a great variety of substrata existing in the soils, they are able to coloni~e feather, fur, nail, hoof, horn, bone, dung, dropptng, paper, decaying vegetable matter and other substrata (47).…”