The Role of Modern Antihistamines in the Treatment of Seasonal Allergies

Terekhova, Ye.P.; Nenasheva, N.M.; Terekhov, D.V.

doi:10.33978/2307-3586-2020-16-8-32-40

Cited by 2 publications

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“…It was found that about 100 plant species are important sources of pollinosis, whose role has been confirmed by allergological studies. It is noted that high prevalence of pollinosis is observed in the North Caucasus, Volga and Ural regions of Russia (up to 80% of all patients with allergic rhinitis) [11][12][13].…”

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confidence: 99%

Analysis of air pollen monitoring results in Perm and determination of main directions of pollen grain transfer

Novoselova

Shvarts

Shklyaev

2022

IOP Conf. Ser.: Earth Environ. Sci.

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This paper considers the atmospheric transport of pollen grains of 15 allergenic plant species. An analysis of monitoring results reveals that the most significant numbers of pollen grains refer to birch, nettle, pine, and poplar. Seasonal changes in the numbers of pollen grains have shown that the pollen of elm, blooming in April, is brought from neighboring regions. In May, the main amounts of the bioaerosol are given by birch, maple, spruce, pine, poplar, oak, and hazel. In the period from June to August, the sources of pollen emissions are cereals, nettles, wormwood, sorrel, and plantain. A good quantitative relationship has been revealed between the contents of pollen grains of plantain and sorrel; cereals and wormwood; cereals and nettles; hazel and plantain. A significant, but less close negative relationship has been found between the numbers of pollen grains of poplar and maple. To account for the wind direction accompanying the transfer of the bioaerosol, daily radio sensing data for the period from April to August, 2010 to 2019, are used. As the main direction of transfer, the level of 925 hPa is chosen, which corresponds to heights from 500 to 900 m. These grouped data allow us to obtain "wind rose" diagrams combined with relative numbers of pollen grains of different species. An analysis of the thus obtained diagrams shows that in some years the highest concentration of birch pollen grains in May may not correspond to the prevailing direction of the main transport, which may be due to the influence of less distant emission sources.

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Section: Introductionmentioning

confidence: 99%

Analysis of air pollen monitoring results in Perm and determination of main directions of pollen grain transfer

Novoselova

Shvarts

Shklyaev

2022

IOP Conf. Ser.: Earth Environ. Sci.

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Features of the modern antihistamines use in the treatment of allergic rhinitis

2021

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Allergic rhinitis remains one of the most relevant problems of modern otorhinolaryngology. The widespread prevalence, late diagnosis, underestimation of the possible risks of disease progression, the development of complications (including asthma) prompts the development and improvement of new treatment options for allergic rhinitis. Allergic rhinitis is a heterogeneous disease that presents with various clinical phenotypes, and therefore the severity of nasal symptoms can vary from mild malaise to severe disease.. Today, pharmacotherapy remains the most frequently used treatment tactic for patients with allergic rhinitis. While prescribing therapy the doctor develops an individual treatment plan based on the principles of personalized medicine, considering: the dominant symptoms, anamnesis data on previous therapy and the effect of treatment, the type of inflammation (Th2-type, mixed inflammation), concomitant diseases (conjunctivitis, asthma, etc.) etc.) and patient preferences. The tissue effects of the histamine mediator lead to the development of symptoms during the course of the disease, which determines the wide-spread use of antihistamines in the treatment of rhinitis. Antihistamines of the second generation are devoid of sedative effects, have a long-lasting effect and a good safety profile. One of the modern II generation antihistamines is bilastine. The research results proved the high antihistaminic activity of bilastine 20 mg in vitro and in vivo, the absence of cardiac and sedative side effects on the central nervous system, the ability to eliminate the nasal and ocular symptoms of disease and improve the quality of life of patients with allergic rhinitis. Thus, bilastine fully complies with current EAACI / WAO ARIA requirements for drugs used to treat AR. The paper presents a clinical case of a patient with chronic persistent allergic rhinitis, household sensitization with a slight uncontrolled course. The oral antihistamine bilastine was added to intranasal glucocorticosteroids, which help to relieve symptoms of the disease, stabilize the condition and prepare the patient for subsequent allergen-specific immunotherapy.

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The Role of Modern Antihistamines in the Treatment of Seasonal Allergies

Cited by 2 publications

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Analysis of air pollen monitoring results in Perm and determination of main directions of pollen grain transfer

Analysis of air pollen monitoring results in Perm and determination of main directions of pollen grain transfer

Features of the modern antihistamines use in the treatment of allergic rhinitis

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