The role of modeling and simulation to improve the treatment of fungal infections caused by Cryptococcus : A literature review
Keli Jaqueline Staudt,
Laura Ben Olivo,
Izabel Almeida Alves
et al.
Abstract:The treatment of fungal infections presents problems in relation to toxicity, pharmacokinetic properties, and undesirable side effects among other factors. An alternative to clarify some of these problems is the use of mathematical modeling and simulation of the pharmacokinetics and pharmacodynamics data of antifungals, in order to seek greater support in decision making regarding the treatment of Cryptococcus infection. Here, we describe the results of
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