2017
DOI: 10.1007/s10557-017-6731-4
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The Role of MKP-1 in Insulin-Induced Cardioprotection

Abstract: Inhibition of MKP-1 with sanguinarine abolished the insulin-induced improvement in functional recovery, but reduced infarct size. Although the data suggest a role for this phosphatase in insulin-induced cardioprotection, the multiple downstream effects of insulin hamper interpretation of the data obtained. In addition, the effects of sanguinarine per se in myocardial ischaemia/reperfusion need to be further elucidated.

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Cited by 7 publications
(4 citation statements)
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“…After screening titles and abstracts, 40 studies were considered potentially eligible for inclusion. After estimating full-text publications, 14 studies were excluded due to intervention or outcome data were unqualified [28][29][30][31][32][33][34][35][36][37][38][39][40][41], and four studies were excluded because pure alkaloids were not assessed [42][43][44][45]. Finally, 22 studies were included in the present meta-analysis [13-14, 19-27, 46-56] (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…After screening titles and abstracts, 40 studies were considered potentially eligible for inclusion. After estimating full-text publications, 14 studies were excluded due to intervention or outcome data were unqualified [28][29][30][31][32][33][34][35][36][37][38][39][40][41], and four studies were excluded because pure alkaloids were not assessed [42][43][44][45]. Finally, 22 studies were included in the present meta-analysis [13-14, 19-27, 46-56] (Figure 1).…”
Section: Resultsmentioning
confidence: 99%
“…1E). Of note, GO and KEGG analyses predicted that MAPK phosphatase activity and the inhibition of MKP-1 mRNA expression might exert a cardioprotective effect in the ischemic rat model (Webster et al, 2017;Yoshikawa et al, 2019).…”
Section: Downregulation Of Mkp-1 Gene Expression In Rat Ischemic Hear...mentioning
confidence: 99%
“…Reperfusion is critical in rescuing the ischemic myocardium from infarction and cardiomyocyte death [43,44]. Insulin protects cardiac myocytes [45,46] while oxidative stress [44] has been implicated in ischemia-reperfusion induced cardiomyocyte apoptosis [44]. In cardiac myocytes, insulin resistance affects the cytoprotective effects of insulin that is mediated by induction of MKP-1 expression [47].…”
Section: Mkp-1 In Cardioprotectionmentioning
confidence: 99%
“…Considering the fact that studies on cardioprotective effects of MKP-1 [45,[47][48][49] including stress-responsive MAPK [68] are controversial, more studies are needed to elucidate how modulation of MKP-1 could be beneficial in the treatment of cardiac diseases. Future work will require cardioprotective analysis of MKP-1 in tissue-specific mouse models.…”
Section: Inhibition Of Mkp-1 In Musclementioning
confidence: 99%