The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive Tract

Abstract

Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.

Transnasal endoscopic repair of choanal atresia in a tertiary care centre: A review of outcomes

“…Besides, the study group were older and had only 2 bilateral cases while the control had 9 (60%) bilateral cases and presented at a younger age. A pubmed search showed 6 more publications (2 case reports and 4 retrospective case series) reporting benefit with the use of mitomycin C in choanal atresia [23,24,[27][28][29][30]. A review of all these publications showed that there was no statistical measures applied to test the significance of the observed benefits and the recent conversion of many to the use of mitomycin C in choanal atresia may not be evidence based.…”

The use of adjunctive topical mitomycin in endoscopic congenital choanal atresia repair

“…Adding very little time to the operation and no complications, mitomycin treatment inhibits fibroblast growth and migration and allows for healing with decreased scar formation. The efficacy of topical mitomycin is reported in different studies [6,7,[22][23][24] from various clinics. As a conclusion they reported that mitomycin not only improves the patency but also decreases the need for dilatations and revision surgery.…”

Mitomycin C in the management of pediatric caustic esophageal strictures

“…Mitomycin C is an antineoplastic agent that inhibits fibroblast proliferation, reduces collagen cross-linking, and has been proven to be effective in reducing scar in animal experiments [2]. It is increasingly being used for the management of laryngotracheal stenosis with encouraging results [3]. We present a case of the use of MMC in the management of caustic esophageal strictures in a toddler.…”