The role of mitochondria in ischemia/reperfusion injury

Jassem, Wayel; Fuggle, Susan V.; Rela, Mohamed; Koo, Dicken D.H.; Heaton, Nigel

doi:10.1097/00007890-200202270-00001

Cited by 210 publications

(168 citation statements)

References 62 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Cytochrome c oxidase (cytochrome aa 3 , complex IV) is the terminal complex of the mitochondrial respiratory chain, which is responsible for about 90% of O 2 consumption in mammals (23). NO reversibly binds to the O 2 binding site of cytochrome oxidase and acts as a potent, rapid, and reversible inhibitor of cytochrome oxidase in competition with molecular O 2 (160,161).…”

Section: Mitochondrial Activity and No-mediated O 2 Consumptionmentioning

confidence: 99%

“…Whereas past investigations have focused mainly on tubular injury as the main cause of ischemia-related acute renal failure, increasing evidence implicates alterations in the intrarenal microcirculation pathway (20)(21)(22) and O 2 handling (23)(24)(25). Indeed, although acute tubular necrosis (ATN) has classically been believed to be the leading cause of ARF (6,26), data from biopsies in patients with ATN have shown few or no changes consistent with tubular necrosis (27).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal Hypoxia and Dysoxia After Reperfusion of the Ischemic Kidney

Legrand

Mik

Johannes³

et al. 2008

Mol Med

237

169

View full text Add to dashboard Cite

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue hypoxia is thought to be a major component in the development of acute renal failure in promoting the initial tubular damage. Renal oxygenation originates from a balance between oxygen supply and consumption. Recent investigations have provided new insights into alterations in oxygenation pathways in the ischemic kidney. These findings have identified a central role of microvascular dysfunction related to an imbalance between vasoconstrictors and vasodilators, endothelial damage and endothelium-leukocyte interactions, leading to decreased renal oxygen supply. Reduced microcirculatory oxygen supply may be associated with altered cellular oxygen consumption (dysoxia), because of mitochondrial dysfunction and activity of alternative oxygen-consuming pathways. Alterations in oxygen utilization and/or supply might therefore contribute to the occurrence of organ dysfunction. This view places oxygen pathways' alterations as a potential central player in the pathogenesis of acute kidney injury. Both in regulation of oxygen supply and consumption, nitric oxide seems to play a pivotal role. Furthermore, recent studies suggest that, following acute ischemic renal injury, persistent tissue hypoxia contributes to the development of chronic renal dysfunction. Adaptative mechanisms to renal hypoxia may be ineffective in more severe cases and lead to the development of chronic renal failure following ischemia-reperfusion. This paper is aimed at reviewing the current insights into oxygen transport pathways, from oxygen supply to oxygen consumption in the kidney and from the adaptation mechanisms to renal hypoxia. Their role in the development of ischemia-induced renal damage and ischemic acute renal failure are discussed.

show abstract

Section: Mitochondrial Activity and No-mediated O 2 Consumptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renal Hypoxia and Dysoxia After Reperfusion of the Ischemic Kidney

Legrand

Mik

Johannes³

et al. 2008

Mol Med

237

169

View full text Add to dashboard Cite

show abstract

“…Several sources may be responsible for oxygen free radical production during ischaemia-reperfusion. These include alterations in mitochondrial electron transport, arachidonic acid metabolism, activation of xanthine oxidase, catecholamines or haemoglobin oxidation, as well as massive release of iron (Jassem et al, 2002). The results from previous studies indicate that leucocytes play a key role in ischaemia-reperfusion injury (Harris et al, 1996).…”

Section: Early Phase Of Reperfusion Of Human Kidney Allograft and Thementioning

confidence: 99%

“…However, proper evaluation of the process seems to be crucial in everyday practice as well as in experimental studies. Thermovision camera helped us to determine the moment when the whole graft was perfused with recipient's blood (Gnaiger et al, 1999;Jassem et al, 2002;Ostrowski et al, 2004). We suggest that this method is an important step to objective assessment of early reperfusion.…”

Section: Activity Of Cuzn-superoxide Dismutase Catalase and Glutathimentioning

confidence: 99%

Ischemia-Reperfusion Injury in the Transplanted Kidney Based on Purine Metabolism Markers and Activity of the Antioxidant System

Domański¹,

Kłoda²,

Ciechanowski³

2012

Organ Donation and Transplantation - Public Policy and Clinical Perspectives

View full text Add to dashboard Cite

“…It performs a plethora of biochemical reactions like oxidative phosphorylation, Krebs cycle, DNA replication, transcription, translation, etc. In addition nuclei are also involved in apoptosis and ionic homeostasis [3]. Because of their multidimensional utility, nuclear proteins are associated with several diseases, including Xeroderma pigmentosum, Fanconis anaemia, Bloom syndrome, Ataxia telangiectasia and Retinoblastoma [4] etc.…”

Section: Introductionmentioning

confidence: 99%

NcPred for Accurate Nuclear Protein Prediction Using n-mer Statistics with Various Classification Algorithms

Islam

Kabir

Sakib

et al. 2011

5th International Conference on Practical Applications of Computational Biology &Amp; Bioinformatics (PACBB 2011)

View full text Add to dashboard Cite

Northumbria University has developed Northumbria Research Link (NRL) to enable users to access the University's research output. Copyright © and moral rights for items on NRL are retained by the individual author(s) and/or other copyright owners. Single copies of full items can be reproduced, displayed or performed, and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided the authors, title and full bibliographic details are given, as well as a hyperlink and/or URL to the original metadata page. The content must not be changed in any way. Full items must not be sold commercially in any format or medium without formal permission of the copyright holder. The full policy is available online: http://nrl.northumbria.ac.uk/policies.html This document may differ from the final, published version of the research and has been made available online in accordance with publisher policies. To read and/or cite from the published version of the research, please visit the publisher's website (a subscription may be required.) NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithmsMd. Saiful Islam, Alaol Kabir, Kazi Sakib, and Md. Alamgir Hossain Abstract Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely Alternating Decision (AD) Tree, Best First (BF) Tree, Random Tree and Adaptive (Ada) Boost. On BaCello dataset [1], NcPred improves about 20% accuracy with Random Tree and about 10% sensitivity with Ada Boost for Animal proteins compared to existing techniques. It also increases the accuracy of Fungal protein prediction by 20% and recall by 4% with AD Tree. In case of Human protein, the accuracy is improved by about 25% and sensitivity about 10% with BF Tree. Performance analysis of NcPred clearly demonstrates its suitability over the contemporary in-silico nuclear protein classification research.

show abstract

The role of mitochondria in ischemia/reperfusion injury

Cited by 210 publications

References 62 publications

Renal Hypoxia and Dysoxia After Reperfusion of the Ischemic Kidney

Renal Hypoxia and Dysoxia After Reperfusion of the Ischemic Kidney

Ischemia-Reperfusion Injury in the Transplanted Kidney Based on Purine Metabolism Markers and Activity of the Antioxidant System

NcPred for Accurate Nuclear Protein Prediction Using n-mer Statistics with Various Classification Algorithms

Contact Info

Product

Resources

About