The role of miRNAs in regulating the effect of prenatal cadmium exposure on ovarian granulosa cells in a transgenerational manner in female rats

Liu, Jin; Liao, Jinglan; Zhang, Chenyun; Zeng, Lingfeng; Zong, Chaowei; Lv, Yake; Li, Jingwen; Zhang, Wenchang

doi:10.1016/j.fct.2021.112062

Cited by 22 publications

(5 citation statements)

References 40 publications

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“…Interestingly, decreased progesterone production and StAR expression were continually observed in the F2 rat offspring, indicating that prenatal cadmium-associated epigenetic alterations could have a transgenerational effect ( Liu et al, 2020 ). Moreover, the apoptotic gene, Bcl2, was significantly altered in the ovarian granulosa cells of F1 and F2 rat offspring, accompanied by increased apoptotic cell bodies ( Liu et al, 2021 ). This was accompanied by differential expression of miR-16-5p and miR92a-2-5p, which are regulators of Bcl2 expression ( Liu et al, 2021 ).…”

Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

“…Moreover, the apoptotic gene, Bcl2, was significantly altered in the ovarian granulosa cells of F1 and F2 rat offspring, accompanied by increased apoptotic cell bodies ( Liu et al, 2021 ). This was accompanied by differential expression of miR-16-5p and miR92a-2-5p, which are regulators of Bcl2 expression ( Liu et al, 2021 ). This indicated that prenatal cadmium exposure dysregulated the expression profile of these miRNAs within the ovarian granulosa cells, thereby leading to increased cell death through modulation of Bcl2, in both F1 and F2 offspring ( Liu et al, 2021 ).…”

Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

“…This was accompanied by differential expression of miR-16-5p and miR92a-2-5p, which are regulators of Bcl2 expression ( Liu et al, 2021 ). This indicated that prenatal cadmium exposure dysregulated the expression profile of these miRNAs within the ovarian granulosa cells, thereby leading to increased cell death through modulation of Bcl2, in both F1 and F2 offspring ( Liu et al, 2021 ). Another recent study investigated the multigenerational effects of prenatal cadmium exposure on testicular function.…”

Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

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The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

Lawless

Xie

Zhang

2023

Front. Cell Dev. Biol.

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Exposure to cadmium during pregnancy, from environmental or lifestyle factors, has been shown to have detrimental fetal and placental developmental effects, along with negatively impacting maternal health during gestation. Additionally, prenatal cadmium exposure places the offspring at risk for developing diseases in infancy, adolescence, and adulthood. Although given much attention, the underlying mechanisms of cadmium-induced teratogenicity and disease development remain largely unknown. Epigenetic changes in DNA, RNA and protein modifications have been observed during cadmium exposure, which implies a scientific premise as a conceivable mode of cadmium toxicity for developmental origins of health and disease (DOHaD). This review aims to examine the literature and provide a comprehensive overview of epigenetic alterations induced by prenatal cadmium exposure, within the developing fetus and placenta, and the continued effects observed in childhood and across generations.

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Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

Section: Cadmium-associated Multigenerational Epigenetic Effectsmentioning

confidence: 99%

See 1 more Smart Citation

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

Lawless

Xie

Zhang

2023

Front. Cell Dev. Biol.

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“… [ 66 ] miR-92a-2-5p (Down), miR-181b-5, (Up) SD rats 0.5–8 mg/kg granulosa cells 0–20 μM, 12 h Bcl-2, Bax miRNA profile could be changed in ovarian granulosa cells of rats exposed to CdCl2 during the prenatal period. [ 67 ] miR-92a-2-5p (Up) Female SD rats 8 mg/kg, postnatal day [ 56 ] granulosa cells, COV434 0–20 μM, 24 h c-Myc, Bcl-2, DNMT3B, DNMT1, DNMT3A After cadmium exposure, in rat ovarian granulosa cells, c-Myc could promote the transcription of miR-92a-2-5p. [ 68 ] miR-101 (Down) – – HUVECs 0–80 μM, 0–36 h COX-2, VEGF, eIF2α miR-101 by sponging COX-2 could suppress angiogenesis induced by CdCl2 in HUVECs.…”

Section: Interaction Between Mirnas and Arsenic Compoundsmentioning

confidence: 99%

The interaction between miRNAs and hazardous materials

Ghafouri‐Fard

Shoorei

Oskuei

et al. 2023

Non-coding RNA Research

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“…Recent studies have confirmed small non-coding RNAs as potential mediators of the transmission of environmental information through germlines 24 , 25 . Notably, the mechanism by which non-genetic factors such as small RNAs are induced by the environment represents one of the most significant questions in the study of transgenerational effects 26 .…”

Section: Introductionmentioning

confidence: 98%

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Zhu,

He,

Wang

et al. 2024

Nat Commun

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Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locust outbreaks. However, the pathway of signal transmission from parents to offspring remains unclear. Here, we find that transcription factor Forkhead box protein N1 (FOXN1) responds to high population density and activates the polypyrimidine tract-binding protein 1 (Ptbp1) in locusts. FOXN1–PTBP1 serves as an upstream regulator of miR-276, a miRNA to control egg-hatching synchrony. PTBP1 boosts the nucleo-cytoplasmic transport of pre-miR-276 in a “CU motif”-dependent manner, by collaborating with the primary exportin protein exportin 5 (XPO5). Enhanced nuclear export of pre-miR-276 elevates miR-276 expression in terminal oocytes, where FOXN1 activates Ptbp1 and leads to egg-hatching synchrony in response to high population density. Additionally, PTBP1-prompted nuclear export of pre-miR-276 is conserved in insects, implying a ubiquitous mechanism to mediate transgenerational effects.

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The role of miRNAs in regulating the effect of prenatal cadmium exposure on ovarian granulosa cells in a transgenerational manner in female rats

Cited by 22 publications

References 40 publications

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

The inter- and multi- generational epigenetic alterations induced by maternal cadmium exposure

The interaction between miRNAs and hazardous materials

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

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