The role of miRNAs in Behçet’s disease

Gu, Feihan; Huang, Xu; Huang, Wenkai; Zhao, Mingyu; Zheng, Hu; Wang, Yuanyin; Chen, Ran

doi:10.3389/fimmu.2023.1249826

Cited by 6 publications

(2 citation statements)

References 127 publications

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“…Recently, non-coding RNAs (ncRNAs) have garnered significant attention for their functions and potential as diagnostic biomarkers in the modulation of inflammation and autoimmune diseases, including BD. 76 Similarly, ncRNAs have been demonstrated to participate in the progression of AAA. 77 Several important computational models, such as the graph convolutional neural (GCN) network and network distance analysis, facilitate the prediction of lncRNA-miRNA interactions.…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

Liu,

Wu,

et al. 2024

J Cellular Molecular Medi

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Behçet's disease (BD) is a complex autoimmune disorder impacting several organ systems. Although the involvement of abdominal aortic aneurysm (AAA) in BD is rare, it can be associated with severe consequences. In the present study, we identified diagnostic biomarkers in patients with BD having AAA. Mendelian randomization (MR) analysis was initially used to explore the potential causal association between BD and AAA. The Limma package, WGCNA, PPI and machine learning algorithms were employed to identify potential diagnostic genes. A receiver operating characteristic curve (ROC) for the nomogram was constructed to ascertain the diagnostic value of AAA in patients with BD. Finally, immune cell infiltration analyses and single‐sample gene set enrichment analysis (ssGSEA) were conducted. The MR analysis indicated a suggestive association between BD and the risk of AAA (odds ratio [OR]: 1.0384, 95% confidence interval [CI]: 1.0081–1.0696, p = 0.0126). Three hub genes (CD247, CD2 and CCR7) were identified using the integrated bioinformatics analyses, which were subsequently utilised to construct a nomogram (area under the curve [AUC]: 0.982, 95% CI: 0.944–1.000). Finally, the immune cell infiltration assay revealed that dysregulation immune cells were positively correlated with the three hub genes. Our MR analyses revealed a higher susceptibility of patients with BD to AAA. We used a systematic approach to identify three potential hub genes (CD247, CD2 and CCR7) and developed a nomogram to assist in the diagnosis of AAA among patients with BD. In addition, immune cell infiltration analysis indicated the dysregulation in immune cell proportions.

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Section: Discussionmentioning

confidence: 99%

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

Liu,

Wu,

et al. 2024

J Cellular Molecular Medi

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“…They are considered essential regulators of T and B immune cell development and functions. Also, they were proven to play significant functions in different human immune disorders like rheumatoid arthritis, systemic lupus erythematosus (Zhang et al 2020 ), and BD (Gu et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease

Abobakr,

Shaker,

Hegazy

et al. 2024

Immunogenetics

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Behcet’s disease (BD) is a multisystem disease with altered Toll-like receptors (TLRs) on macrophages. Long noncoding RNA Maternally expressed gene 3 (lncRNA MEG3) and lncRNA Musculoaponeurotic fibrosarcoma oncogene family, protein G antisense 1 (MAFG-AS1) are regulators of microRNA (miRNA) 147-b, which is induced upon TLR stimulation. We included fifty BD patients, and fifty age and sex-matched controls. Real-time polymerase chain reaction (PCR) was used to measure the expression levels of serum lncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147-b. LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated while miRNA 147-b was significantly upregulated in the BD patients' serum compared to the controls with p-value <0.001. Receiver operation characteristics (ROC) curve analysis revealed that the three biomarkers can discriminate between BD and control subjects with 76%, 100%, and 70% sensitivity respectively, and 100% specificity for all of them. There was a lower expression level of lnc RNA MEG3 among patients who had new eye involvement in the last month in comparison to those without new eye involvement (p-value=0.017). So, LncRNA MEG3, lncRNA MAFG-AS1, and miRNA147-b are promising diagnostic markers and therapeutic targets for BD patients. LncRNA MEG3 can be used as a predictor for new BD ocular involvement.

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Microribonucleic acid-9 (miRNA-9) as a potential diagnostic marker in Behҫet’s syndrome patients

Saad,

El Gendy,

Behiry

et al. 2024

The Egyptian Rheumatologist

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The role of miRNAs in Behçet’s disease

Cited by 6 publications

References 127 publications

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses

A possible role of lncRNA MEG3 and lncRNA MAFG-AS1 on miRNA 147-b in the pathogenesis of Behcet’s disease

Microribonucleic acid-9 (miRNA-9) as a potential diagnostic marker in Behҫet’s syndrome patients

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