The role of miRNAs in laryngeal cancer pathogenesis and therapeutic resistance – A focus on signaling pathways interplay

Hegazy, Maghawry; El‐Kady, M. A.; Yehia, Amr Mohamed; Elsakka, Elsayed G.E.; Abulsoud, Ahmed I.; Abdelmaksoud, Nourhan M.; Elshafei, Ahmed; Abdelghany, Tamer M.; Elkhawaga, Samy Y.; Ismail, Ahmed; Mokhtar, Mahmoud Mohamed; El-Mahdy, Hesham A.; Doghish, Ahmed S.

doi:10.1016/j.prp.2023.154510

Cited by 40 publications

(5 citation statements)

References 203 publications

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“…miRNAs are a type of non-coding RNA (ncRNA) that plays a crucial role in a wide variety of biological processes [ 77 ]. Based on the latest research, it has been shown that alterations to miRNAs are what initially set the stage for the development of cancer [ 9 ]. Molecular changes found in carcinogenesis, such as transcriptional deregulations, chromosomal editing, protein abnormalities, and so on, can cause modifications in miRNAs.…”

Section: Discussionmentioning

confidence: 99%

“…As demonstrated by Hegazy et al, specific miRNAs are widely recognized to be associated with tumor occurrence, even in their earliest stages, or with a worse prognosis. Consequently, miRNAs could serve as promising candidates for biomarkers [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Molecular changes found in carcinogenesis, such as transcriptional deregulations, chromosomal editing, protein abnormalities, and so on, can cause modifications in miRNAs. In a recent study, Hegazy et al [9] stated that the advancement of LSCC is influenced by the alteration of miRNA expression. In particular, laryngeal cancer cells show downregulation of miR-138, which leads to less apoptosis and more cell proliferation [78].…”

Section: The Emerging Role Of Lncrnas Mirnas and Mrnasmentioning

confidence: 99%

“…Moreover, miRNAs may possess tumor-suppressive properties or be oncogenic. Recent studies have demonstrated that miRNAs can also influence resistance to different treatments, such as radiotherapy, chemotherapy, and immunotherapy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Updates on Larynx Cancer: Risk Factors and Oncogenesis

Liberale,

Soloperto,

Marchioni

et al. 2023

IJMS

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Laryngeal cancer is a very common tumor in the upper aero-digestive tract. Understanding its biological mechanisms has garnered significant interest in recent years. The development of laryngeal squamous cell carcinoma (LSCC) follows a multistep process starting from precursor lesions in the epithelium. Various risk factors have been associated with laryngeal tumors, including smoking, alcohol consumption, opium use, as well as infections with HPV and EBV viruses, among others. Cancer development involves multiple steps, and genetic alterations play a crucial role. Tumor suppressor genes can be inactivated, and proto-oncogenes may become activated through mechanisms like deletions, point mutations, promoter methylation, and gene amplification. Epigenetic modifications, driven by miRNAs, have been proven to contribute to LSCC development. Despite advances in molecular medicine, there are still aspects of laryngeal cancer that remain poorly understood, and the underlying biological mechanisms have not been fully elucidated. In this narrative review, we examined the literature to analyze and summarize the main steps of carcinogenesis and the risk factors associated with laryngeal cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Emerging Role Of Lncrnas Mirnas and Mrnasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Updates on Larynx Cancer: Risk Factors and Oncogenesis

Liberale,

Soloperto,

Marchioni

et al. 2023

IJMS

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“…In a study of 10,841 laryngeal cancer cases, Broseghini and co-workers found that 69 miRNAs are upregulated in the tumor and 95 miRNAs are downregulated in tumor compared to normal mucosa-the downregulated miRNAs are putative tumor suppressor miRNAs [8]. MiRNAs are found to be linked to several cancers because they can affect mRNA translation through the repression of specific mRNAs during translation or accelerating the destruction of mRNAs, which can trigger cancers, and it has been shown that specific miRNAs are linked to the occurrence of tumors [9,10]. Since miRNAs are stable in bodily fluids like blood, urine, and saliva, they offer a minimally invasive means of assessing disease states and therapeutic efficacy [11].…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Cancer Diagnosis via miRNA-based Decision Tree Model

Arora,

Tsigelny,

Kouznetsova

2023

Preprint

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Purpose Laryngeal cancer (LC) is the most common head and neck cancer, which often goes undiagnosed due to the expensiveness and inaccessible nature of current diagnosis methods. Many recent studies have shown that microRNAs (miRNAs) are crucial biomarkers for a variety of cancers. Methods In this study, we create a decision tree model for the diagnosis of laryngeal cancer using a calculated miRNAs’ attributes, such as sequence-based characteristics, predicted miRNA target genes, and gene pathways. This series of attributes is extracted from both differentially expressed blood-based miRNAs in laryngeal cancer and random, non-associated with cancer miRNAs. Results Several machine-learning (ML) algorithms were tested in the ML model, and the Hoeffding Tree (HT) classifier yields the highest accuracy (86.8%) in miRNAs-based recognition of laryngeal cancer. Furthermore, HT-based model is validated with the independent laryngeal cancer datasets and can accurately diagnose laryngeal cancer with 86% accuracy. We also explored the biological relationships of the attributes used in HT-based model to understand their relationship with cancer proliferation or suppression pathways. Conclusion Our study demonstrates that the proposed model and an inexpensive miRNA testing strategy have the potential to serve as a cost-effective and accessible method for diagnosing laryngeal cancer.

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