The role of miRNAs in the regulation of autophagy in autoimmune diseases

Khodakarimi, Sina; Zarebkohan, Amir; Kahroba, Houman; Omrani, Mohammadhassan; Sepasi, Tina; Mohaddes, Gisou; Beyrampour-Basmenj, Hanieh; Ebrahimi, Ayyub; Ebrahimi-Kalan, Abbas

doi:10.1016/j.lfs.2021.119726

Cited by 7 publications

(5 citation statements)

References 104 publications

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“…Many microRNAs (miRNAs) regulate the autophagy pathway and influence various body processes (Khodakarimi et al, 2021 ), including miR-34a, miR-96, miR-182, and miR-183, which are associated with apoptosis and autophagy. For example, miR-34 overexpression significantly decreased ovarian cancer cell proliferation by activating apoptosis and autophagy (Jia et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

“…BIX01294 is an inhibitor of G9a, the enzyme in charge of Histone H3 lysine 9 dimethylation (H3K9me2), and can induce autophagy in various cell types, including neuroblastoma (Ke et al, 2014 ), glioma stem-like (Ciechomska et al, 2016 ), oral squamous cell carcinoma (Ren et al, 2015 ), breast and colon cancer (Kim et al, 2013 ), and osteosarcoma (Fan et al, 2015 ) cells. Many microRNAs (miRNAs) regulate the autophagy pathway and influence body processes (Mao et al, 2018 ; Yuan et al, 2018 ; Chen et al, 2019 ; Xie et al, 2019 ; Khodakarimi et al, 2021 ). In addition, BIX01294 can reduce HCs loss in organ of Corti explant under cisplatin treatment (Yu et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

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Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Zou

et al. 2023

Front. Mol. Neurosci.

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Cisplatin is widely used in clinical tumor chemotherapy but has severe ototoxic side effects, including tinnitus and hearing damage. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. In this study, we used CBA/CaJ mice to establish an ototoxicity model of cisplatin-induced hair cell loss, and our results showed that cisplatin treatment could reduce FOXG1 expression and autophagy levels. Additionally, H3K9me2 levels increased in cochlear hair cells after cisplatin administration. Reduced FOXG1 expression caused decreased microRNA (miRNA) expression and autophagy levels, leading to reactive oxygen species (ROS) accumulation and cochlear hair cell death. Inhibiting miRNA expression decreased the autophagy levels of OC-1 cells and significantly increased cellular ROS levels and the apoptosis ratio in vitro. In vitro, overexpression of FOXG1 and its target miRNAs could rescue the cisplatin-induced decrease in autophagy, thereby reducing apoptosis. BIX01294 is an inhibitor of G9a, the enzyme in charge of H3K9me2, and can reduce hair cell damage and rescue the hearing loss caused by cisplatin in vivo. This study demonstrates that FOXG1-related epigenetics plays a role in cisplatin-induced ototoxicity through the autophagy pathway, providing new ideas and intervention targets for treating ototoxicity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Zou

et al. 2023

Front. Mol. Neurosci.

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“…miRNAs belong to a group of non-coding RNAs with 18 to 25 nucleotides in length and can degrade or suppress target mRNAs' translation through base-pairing with their 3' UTR sites [27]. Numerous studies have shown that miRNAs have crucial roles in various physiological and pathological processes, including metabolism, proliferation, differentiation, and carcinogenesis [28].…”

Section: Discussionmentioning

confidence: 99%

miR-378a-5p represses Barrett’s esophagus cells proliferation, migration and invasion through targeting TSPAN8

Xudong Xie,

Duo Wei

2024

Cell Mol Biol (Noisy-le-grand)

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Barrett's esophagus (BE) belongs to a pathological phenomenon occurring in the esophagus, this paper intended to unveil the underlying function of miR-378a-5p and its target TSPAN8 in BE progression. GEO analysis was conducted to determine differentially expressed genes in BE samples. Non-dysplastic metaplasia BE samples, high-grade dysplastic BE samples and controls were collected from subjects. CP-A and CP-B cells were exposed to bile acids (BA) to mimic gastroesophageal reflux in BE cells. RT-qPCR as well as western blot were applied for verifying expressions of miR-378a-5p, TSPAN8, CDX2 and SOX9. CCK-8, wound scratch together with Transwell assays were exploited for ascertaining cell proliferation, migration as well as invasion. The targeted relationship of miR-378a-5p and TSPAN8 could be verified by correlation analysis, dual-luciferase reporter experiment, and rescue experiments. Through analyzing GSE26886 dataset, we screened the most abundantly expressed gene TSPAN8 in BE samples. miR-378a-5p was reduced whereas TSPAN8 was elevated in CP-A as well as CP-B cells after triggering with BA. Knocking down TSPAN8 could counteract BA-triggered enhancement in BE cell proliferation, migration along with invasion. miR-378a-5p could suppress BE cell proliferation, and migration along with invasion via targeting TSPAN8. In BE, miR-378a-5p targeted TSPAN8 to inhibit BE cell proliferation, and migration along invasion. miR-378a-5p deletion or elevation of TSPAN8 may be key point in regulating CDX2 and SOX9 levels, thereby promoting BE formation.

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“…miRNAs are involved in the regulation of several human diseases including cancer, liver diseases, neurodegenerative diseases, and autoimmune diseases, and therefore affects many developmental pathways and cellular processes (1,(6)(7)(8)(9). Furthermore, miRNAs are known to play regulatory roles in the pathogenesis of different viral diseases, including in human immunodeficiency virus (HIV)-related disease (10).…”

Section: Introductionmentioning

confidence: 99%

The diverse roles of miRNAs in HIV pathogenesis: Current understanding and future perspectives

et al. 2023

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Despite noteworthy progress made in the management and treatment of HIV/AIDS-related disease, including the introduction of the now almost ubiquitous HAART, there remains much to understand with respect to HIV infection. Although some roles that miRNAs play in some diseases have become more obvious of late, the roles of miRNAs in the context of HIV pathogenesis have not, as yet, been elucidated, and require further investigations. miRNAs can either be beneficial or harmful to the host, depending upon the genes they target. Some miRNAs target the 3′ UTR of viral mRNAs to accomplish restriction of viral infection. However, upon HIV-1 infection, there are several dysregulated host miRNAs which target their respective host factors to either facilitate or abrogate viral infection. In this review, we discuss the miRNAs which play roles in various aspects of viral pathogenesis. We describe in detail the various mechanisms thereby miRNAs either directly or indirectly regulate HIV-1 infection. Moreover, the predictive roles of miRNAs in various aspects of the HIV viral life cycle are also discussed. Contemporary antiretroviral therapeutic drugs have received much attention recently, due to their success in the treatment of HIV/AIDS; therefore, miRNA involvement in various aspects of antiretroviral therapeutics are also elaborated upon herein. The therapeutic potential of miRNAs are discussed, and we also propose herein that the therapeutic potential of one specific miRNA, miR-34a, warrants further exploration, as this miRNA is known to target three host proteins to promote HIV-1 pathogenesis. Finally, future perspectives and some controversy around the expression of miRNAs by HIV-1 are also discussed.

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The role of miRNAs in the regulation of autophagy in autoimmune diseases

Cited by 7 publications

References 104 publications

Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

Role and mechanism of FOXG1-related epigenetic modifications in cisplatin-induced hair cell damage

miR-378a-5p represses Barrett’s esophagus cells proliferation, migration and invasion through targeting TSPAN8

The diverse roles of miRNAs in HIV pathogenesis: Current understanding and future perspectives

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