The Role of miRNAs, circRNAs and Their Interactions in Development and Progression of Hepatocellular Carcinoma: An Insilico Approach

Abstract

Hepatocellular carcinoma (HCC) is a type of malignant tumor. miRNAs are noncoding RNAs and their differential expression patterns are observed in HCC-induced by alcoholism, HBV and HCV infections. By acting as a competing endogenous RNA (ceRNA), circRNA regulates the miRNA function, indirectly controlling the gene expression and leading to HCC progression. In the present study, data mining was performed to screen out all miRNAs and circRNA involved in alcohol, HBV or HCV-induced HCC with statistically significant (≤0.05%) expression levels reported in various studies. Further, the interaction of miRNAs and circRNA was also investigated to explore their role in HCC due to various causative agents. Together, these study data provide a deeper understanding of the circRNA–miRNA regulatory mechanisms in HCC. These screened circRNA, miRNA and their interactions can be used as prognostic biomarkers or therapeutic targets for the treatment of HCC.

The Interaction between Stress and Inflammatory Bowel Disease in Pediatric and Adult Patients

“…Extensive research has focused on understanding the roles and modifications of miRNAs in cancer development and progression, with potential implications for significant clinical and therapeutic advancements in molecular research. Additionally, in vitro studies highlight miRNAs as promising candidates for molecular replacement therapy, offering potential avenues to hinder cancer progression, prevent lymph node metastasis, and induce tumor cell apoptosis [ 282 , 283 ]. Furthermore, every investigation into miRNAs advances our understanding of the molecular mechanisms underlying oncogenesis and neurodegenerative disorders.…”

“…Furthermore, every investigation into miRNAs advances our understanding of the molecular mechanisms underlying oncogenesis and neurodegenerative disorders. Recent research underscores the significance of exploring miRNAs and their target genes for their prospective contributions to personalized treatment strategies across diverse diseases [ 279 , 282 , 283 ].…”

“…In the realm of brain development, a solitary miRNA may participate in multiple processes, including synaptic formation and neural development. Contemporary molecular research is centered on identifying clinical alterations resulting from miRNA dysregulation to tailor targeted treatments for various diseases [ 279 , 280 , 282 , 284 ]. Research indicates that miRNAs play a pivotal role in neurological disorders by modulating both the inflammatory response and nerve injury [ 279 , 285 ].…”

Has-miR-129-5p’s Involvement in Different Disorders, from Digestive Cancer to Neurodegenerative Diseases

“…MiRNAs are molecules that respond to stress; in this context, we note that physiological stress causes dysregulation in the expression of miRNAs, showing a higher prevalence in the central amygdala as well as in the hippocampus. In addition, chronic stress results in dysregulation of miRNAs in the frontal cortex, causing depression and neurodegenerative diseases [46][47][48][49][50][51][52]. A study realized by Qinlin.…”

What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

“…Previous research has shown that a great quantity of miRNAs are aberrantly expressed in various cancer cell lines and tissues, and they participate in the biological processes such as the tumor invasion, metastasis, autophagy, regulation of the tumor microenvironment, chemotherapy resistance, and immunotherapy modulation[ 8 - 12 ]. As competitive endogenous RNAs, long noncoding RNAs (lncRNAs) and circRNAs contain miRNA binding sites and promote miRNA target gene expression through competition with miRNAs[ 13 - 17 ]. For example, Wang et al [ 18 ] identified and verified a novel MAGI2-AS3/miRNA-374-5p/FOXO1 network that was associated with HBV-related HCC.…”