The Role of miRNA-424 in Various Cancers: Focusing on Drug Resistance and Sensitivity

Abstract

However, advanced technologies have been developed in the treatment of various cancers the mortality rate of this disease is still very high. Drug resistance is a major problem for cancer patients which causes the treatment process to fail. In addition to inhibiting drug resistance, targeted therapy is also very important in its treatment. Nowadays, miRNAs have gained increasing interest in recent years which play a major role in both drug resistance and target therapy. MicroRNA (miRNA) is an important part of non-coding RNA that regulates gene expression at a posttranscriptional level. One of these microRNAs is miR-424 that by targeting genes involved in various cellular processes can participate in proliferation, differentiation, apoptosis, invasion, angiogenesis, and drug resistance and sensitivity. In this study, we collected the role of miR-424 in a variety of cancers and by identifying the role of miR-424 in drug resistance we can reduce the effect of drug resistance in many cancers.