The role of miR-320 in glucose and lipid metabolism disorder-associated diseases

Du, Hengzhi; Zhang, Yanru; Yin, Zongsheng; Wang, Dao Wen; Chen, Chen

doi:10.7150/ijbs.53419

Cited by 38 publications

(40 citation statements)

References 148 publications

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“…1 and 2, both miR-27b-3p, miR-320b have multiple targets that can have modulatory effects on brain function. This is consistent with ndings from case-control studies in anxiety or depression showing evidence for an increase in miRs including miR-27b-3 59 and miR-320b 34 , which has been more closely related to metabolic dysfunction 19,20 . For example, global upregulation of miR-320 has been associated with impaired gluconeogenesis, lipid metabolism, and relatively higher expression of in ammation markers 60 .…”

Section: Discussionsupporting

confidence: 91%

“…In comparison, miR-320b is an intragenic miR on chromosome 1 that has been implicated in neuronal differentiation 30,31 , regulation of in ammatory processes via the nucleotide-binding oligomerization domain 32 , and regulation of endoplasmic reticulum stress 33 . miR-320b is robustly increased in anterior cingulate cortex and habenula of individuals with MDD 34 , regions of the brain thought to be important for pain affect and processing 35,36 . Figure 2 shows additional gene targets for miR-320b including DTNA, NUMB, MDFIC, TVP23A, and SEC14L1, which are responsible for functions such as formation and stability of synapses, local repair of brain ventricular wall damage, WNT and JNK signaling, vesiclemediated transport, and innate immune-mediated antiviral inhibition 37 .…”

Section: Introductionmentioning

confidence: 99%

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Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Burrows

Figueroa-Hall

Kuplicki

et al. 2021

Preprint

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This double-blind, randomized, repeated measures study evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females,10 males) completed a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from plasma and sequenced. Results showed that: (1) 600 mg of ibuprofen exhibited higher miR-27b-3p, miR-320b, miR-23b and miR-203a-3p expression than placebo; (2) higher mir-27b-3p was associated with lower insula activation during MID loss anticipation; and (3) there was an inverse relationship between miR-27b-3p and MID gain anticipation in bilateral putamen during placebo, a pattern attenuated by both 200 mg and 600 mg of ibuprofen. Our findings indicate that miR-27b could be an important messaging molecule altered by anti-inflammatory drugs that relates to the processing of positive or negative valenced information.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Burrows

Figueroa-Hall

Kuplicki

et al. 2021

Preprint

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“…Glucose and lipid metabolism are closely linked and the stability of these two metabolic pathways is critical for maintaining body organ function ( Du et al, 2021 ). Insulin resistance is highly associated with the occurrence and development of glucose metabolism disorder ( James et al, 2021 ).…”

Section: The Role Of Ectodysplasin a In Metabolic Diseasesmentioning

confidence: 99%

Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases

et al. 2021

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Ectodysplasin A (EDA) is a member of the tumor necrosis factor (TNF) family of ligands that was initially reported to induce the formation of various ectodermal derivatives during normal prenatal development. EDA exerts its biological activity as two splice variants, namely, EDA-A1 and EDA-A2. The former binds to the EDA receptor (EDAR), resulting in the recruitment of the intracellular EDAR-associated death domain (EDARADD) adapter protein and the activation of the NF-κB signaling pathway, while the latter binds to a different receptor, EDA2R, also known as X-linked ectodermal dysplasia receptor (XEDAR). Inactivation mutation of the EDA gene or the genes coding for its receptors can result in hypohidrosis ectodermal dysplasia (HED), a condition that is characterized by oligotrichosis, edentulosis or oligodontia, and oligohidrosis or anhidrosis. Recently, as a new liver factor, EDA is gradually known and endowed with some new functions. EDA levels were observed to be upregulated in several metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD), obesity, and insulin resistance. In addition, EDA and its receptors have been implicated in tumor pathogenesis through the regulation of tumor cell proliferation, apoptosis, differentiation, and migration. Here, we first review the role of EDA and its two-receptor system in various signaling pathways and then discuss the physiological and pathological roles of EDA and its receptors.

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“…We have also shown that expression levels of miR-223 and miR-320a, as well as miR-320a and miR-486 were positively correlated during the whole training cycle. The miR-320 regulates glucose and lipid metabolism, as well as responses to oxidative stress-induced glycolysis [ 53 , 54 ]. Increased concentration of miR-320 in skeletal muscles reduces the lactate level, whereas its decreased concentration predisposes to the development of type II diabetes and may serve as a predictor biomarker of this condition because reduced circulating level of miR-320 precedes disease symptoms [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Increased concentration of miR-320 in skeletal muscles reduces the lactate level, whereas its decreased concentration predisposes to the development of type II diabetes and may serve as a predictor biomarker of this condition because reduced circulating level of miR-320 precedes disease symptoms [ 55 ]. In a rat model of myocardial ischemia–reperfusion injury, the expression level of miR-320 is significantly upregulated and leads to mitochondrial apoptosis in cardiomyocytes [ 54 , 56 ]. MiR-320a regulates skeletal muscle mitochondrial metabolism and mitochondrial oxidative capacity [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players

Podgórski

Cieśla

Podgórska

et al. 2022

JCM

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A deeper insight into the mechanisms responsible for athlete performance that may serve as specific and detailed training indicators is still desired, because conventionally used biomarkers provide limited information about the adaptive processes that occur during exercise. The objective of our study was to assess insulin-like growth factor 1 receptors (IGF1R) gene expression and evaluate plasma concentration of selected microRNAs (miRNAs) during a 10-week training period (sampling times: week 1, 4, 7, and 10) in a group of 12 professional female volleyball players. Circulating miRNAs (miR-223, miR-320a, and miR-486) with established concentration in plasma and documented association with the IGF1 signaling pathway, which is involved in muscle development and recovery, were tested. The levels of analyzed miRNAs, tested by one-way ANOVA, were significantly different between four training periods during a 10-week training cycle (miR-223 p < 0.0001, miR-320a p = 0.00021, miR-486 p = 0.0037, respectively). The levels of IGF1R also appeared to be different (p = 0.00092), and their expression showed a trend to increase between the first and third periods. In the fourth period, the expression decreased, although it was higher compared with the baseline. Correlations between concentration levels of miR-223 and miR-320a (rs = 0.54, p < 0.001), as well as between miR-320a and miR-486 (rs = 0.73, p < 0.001) were also found. In the fourth period, a negative correlation between miR-223 plasma level and leucocyte IGF1R expression was found (rs = −0.63, p = 0.028). Multiple linear regression analysis showed that miR-320a (p = 0.024) and creatine kinase (p = 0.028) had the greatest impact on the expression levels of the IGF1R gene. Future studies are required to define whether these miRNAs, especially miR-320a, as well as IGF1R expression could be useful biomarkers of physiological changes during exercise and to discover their detailed biological roles in mode-specific exercise training adaptations of professional athletes.

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The role of miR-320 in glucose and lipid metabolism disorder-associated diseases

Cited by 38 publications

References 148 publications

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Neuronally-Enriched Exosomal miR-27b Reveals Mechanism for Ibuprofen-Induced Acute Effects on Reward-Related Brain Processing in a Randomized, Placebo-Controlled, Double-Blind Trial

Ectodysplasin A/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases

Plasma microRNA-320a as a Potential Biomarker of Physiological Changes during Training in Professional Volleyball Players

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