The Role of miR-155 in Nutrition: Modulating Cancer-Associated Inflammation

Abstract

Nutrition plays an important role in overall human health. Although there is no direct evidence supporting the direct involvement of nutrition in curing disease, for some diseases, good nutrition contributes to disease prevention and our overall well-being, including energy level, optimum internal function, and strength of the immune system. Lately, other major, but more silent players are reported to participate in the body’s response to ingested nutrients, as they are involved in different physiological and pathological processes. Furthermore, the genetic profile of an individual is highly critical in regulating these processes and their interactions. In particular, miR-155, a non-coding microRNA, is reported to be highly correlated with such nutritional processes. In fact, miR-155 is involved in the orchestration of various biological processes such as cellular signaling, immune regulation, metabolism, nutritional responses, inflammation, and carcinogenesis. Thus, this review aims to highlight those critical aspects of the influence of dietary components on gene expression, primarily on miR-155 and its role in modulating cancer-associated processes.

MicroRNAs expressed during normal wound healing and their associated pathways: A systematic review and bioinformatics analysis

“…On day 1, among the miRNAs with an increase in their expression (mmu-miR-223-3p and mmu-miR-34c-5p), already it is possible to observe the correlation with wound healing. Evidence had shown that mmu-miR-223-3p can ameliorates vascular endothelial lesions through the IL6ST and STAT3 signaling pathways [ 23 , 30 ]. Furthermore, members of the miR-223 family have been associated as important regulators in the inflammatory process that occurs during early phases of wound healing, which justifies its increase in expression on day 1, when the inflammatory process of tissue repair occurs.…”

The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

“…MicroRNAs regulate inflammation by modulating inflammatory pathways. Evidence has shown that miR-155 (a non-coding micro-RNA) is involved in cellular signaling, immune regulation, inflammation, and metabolism and is highly correlated with nutrition [ 67 ].…”

“…For example, flavonoids such as resveratrol and quercetin were reported to be the potent epigenetic modulators of miR-155 expression, followed by inhiation of NF-kB activation and anti-inflammatory action [ 14 , 68 , 69 ]. Moreover, supplementation with quercetin showed a decrease in the expression of TNF-α, IL-6, and IL-17 and a decrease in the expression of the NF-κB through changes in the expression of miR-146 [ 5 , 14 , 67 , 69 ].…”

Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review

“…miRNA155 has also been shown to inhibit FOXO3a expression, promoting apoptosis and inflammation. 97 MiRNA192 is essential for the correct functioning of the colon's epithelial barrier and inflammation, further, affects the operation of tight junctions, which form seals between neighboring epithelial cells and prevent undesirable molecules from entering the circulation. MiRNA192 inhibits the production of tight junction proteins such claudin-1 and occludin, resulting in enhanced paracellular permeability.…”