The Role of microRNA in the Inflammatory Response of Wound Healing

Jiang, Yuanyuan; Xu, Xiang Xi; Xiao, Long; Wang, Lihong; Qiang, Sheng

doi:10.3389/fimmu.2022.852419

Cited by 31 publications

(28 citation statements)

References 111 publications

(118 reference statements)

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“…The role of miRs as regulatory molecules is observed in all phases of the wound healing process including the inflammation phase and proliferation phase involving angiogenesis, re-epithelialization, and granulation tissue formation to accelerate wound healing process [ 309 , 310 ]. A list of miRs and their role in different phases of wound healing is listed in Table 5 .…”

Section: Innovative Strategies For Wound Healingmentioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

141

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Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in the normal wound healing process results in abnormal scar formation, and chronic state which is more susceptible to infections. Chronic wounds affect patients’ quality of life along with increased morbidity and mortality and are huge financial burden to healthcare systems worldwide, and thus requires specialized biomedical intensive treatment for its management. The clinical assessment and management of chronic wounds remains challenging despite the development of various therapeutic regimens owing to its painstakingly long-term treatment requirement and complex wound healing mechanism. Various conventional approaches such as cell therapy, gene therapy, growth factor delivery, wound dressings, and skin grafts etc., are being utilized for promoting wound healing in different types of wounds. However, all these abovementioned therapies are not satisfactory for all wound types, therefore, there is an urgent demand for the development of competitive therapies. Therefore, there is a pertinent requirement to develop newer and innovative treatment modalities for multipart therapeutic regimens for chronic wounds. Recent developments in advanced wound care technology includes nanotherapeutics, stem cells therapy, bioengineered skin grafts, and 3D bioprinting-based strategies for improving therapeutic outcomes with a focus on skin regeneration with minimal side effects. The main objective of this review is to provide an updated overview of progress in therapeutic options in chronic wounds healing and management over the years using next generation innovative approaches. Herein, we have discussed the skin function and anatomy, wounds and wound healing processes, followed by conventional treatment modalities for wound healing and skin regeneration. Furthermore, various emerging and innovative strategies for promoting quality wound healing such as nanotherapeutics, stem cells therapy, 3D bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based approaches, and cold plasma treatment therapy have been discussed with their benefits and shortcomings. Finally, challenges of these innovative strategies are reviewed with a note on future prospects.

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Section: Innovative Strategies For Wound Healingmentioning

confidence: 99%

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Kolimi

Narala

Nyavanandi

et al. 2022

Cells

141

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“…Small, non-coding RNAs, namely miRNAs (18–24 nucleotides), play a vital role in regulating apoptosis by intrinsic and extrinsic pathways [ 25 ]. These molecules act post-translationally, targeting pro-and anti-apoptotic genes [ 25 , 26 , 27 ]. It was found that an overexpressed miR-761 might alleviate chronic inflammation and induce the remodelling of nasal mucosa in CRS mice.…”

Section: Introductionmentioning

confidence: 99%

Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)—Evaluation at mRNA and miRNA Levels

et al. 2022

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In chronic upper respiratory tract diseases, increased cell proliferative activity is observed, which is coordinated by BCL-2 proteins and small non-coding RNAs. This study aimed to determine the expression of critical apoptosis markers at the mRNA and miRNA levels in patients with chronic rhinosinusitis with nasal polyps (CSRwNP). The study group consisted of ten patients with CSRwNP and ten healthy subjects. To detect in situ apoptosis in the maxillary sinus mucosa, TUNEL staining was performed. The expression of transcripts was determined by RT-qPCR and included the detection of markers associated with cell survival and apoptosis, i.e., BAX, p53, p21, CASP3, CASP9, c-MYC, CCND1, BRIC5, and APAF1. Levels of miR-17-5p, miR-145-5p, miR-146a-5p, and miR-203a-3p were also measured by RT-qPCR. The obtained results indicated increased apoptosis determined by a TUNEL assay in CSRwNP patients and accompanied by an increased expression of BAX, P21, P53, CASP3, CASP9, c-MYC, and APAF-1 transcripts and decreased mRNA levels of BCL-2 and BIRC5. Furthermore, the nasal sinus epithelium of patients with CSRwNP showed increased levels of miR-203a-3p while also showing a decreased expression of miR-17-5p and miR-145-5p. Our results showed that pro-apoptotic transcripts detected at mRNA and miRNA levels might be involved in the pathogenesis of chronic sinusitis with polyps. The identification of those key molecular mediators may be applicable for the specific diagnostic and/or development of targeted therapies for chronic sinusitis with polyps.

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“…As the largest organ of the human body, the skin requires a large amount of highly regulated miRNAs for its development and morphogenesis. miRNAs are involved in skin immunity, cell proliferation, aging, pigmentation, wound healing, and cutaneous microbiomes [ 18 , 19 ]. miRNAs also play a role in skin cancers, inflammatory skin diseases, and autoimmune skin disorders.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases

et al. 2022

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Skin inflammation occurs due to immune dysregulation because of internal disorders, infections, and allergic reactions. The inflammation of the skin is a major sign of chronic autoimmune inflammatory diseases, such as psoriasis, atopic dermatitis (AD), and lupus erythematosus. Although there are many therapies for treating these cutaneous inflammation diseases, their recurrence rates are high due to incomplete resolution. MicroRNA (miRNA) plays a critical role in skin inflammation by regulating the expression of protein-coding genes at the posttranscriptional level during pathogenesis and homeostasis maintenance. Some miRNAs possess anti-inflammatory features, which are beneficial for mitigating the inflammatory response. miRNAs that are reduced in inflammatory skin diseases can be supplied transiently using miRNA mimics and agomir. miRNA-based therapies that can target multiple genes in a given pathway are potential candidates for the treatment of skin inflammation. This review article offers an overview of the function of miRNA in skin inflammation regulation, with a focus on psoriasis, AD, and cutaneous wounds. Some bioactive molecules can target and modulate miRNAs to achieve the objective of inflammation suppression. This review also reports the anti-inflammatory efficacy of these molecules through modulating miRNA expression. The main limitations of miRNA-based therapies are rapid biodegradation and poor skin and cell penetration. Consideration was given to improving these drawbacks using the approaches of cell-penetrating peptides (CPPs), nanocarriers, exosomes, and low-frequency ultrasound. A formulation design for successful miRNA delivery into skin and target cells is also described in this review. The possible use of miRNAs as biomarkers and therapeutic modalities could open a novel opportunity for the diagnosis and treatment of inflammation-associated skin diseases.

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The Role of microRNA in the Inflammatory Response of Wound Healing

Cited by 31 publications

References 111 publications

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

Expression of Apoptosis-Related Biomarkers in Inflamed Nasal Sinus Epithelium of Patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)—Evaluation at mRNA and miRNA Levels

Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases

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