The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy

Szostak, Joanna; Gorący, Anna; Durys, Damian; Dec, Paweł; Modrzejewski, Andrzej; Pawlik, Andrzej

doi:10.3390/ijms24076214

Cited by 12 publications

(6 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In long-standing diabetes mellitus (DM), there is an increase in TGF-β expression mediated through protein kinase C, polyol, and hexosamine pathways. MiR-192 could be the link between liver fibrosis and diabetic nephropathy (DN) as it is upregulated not only in our MAFLD patients but also in DN patients ( 35 ). The presence of T2DM could be one of the predictors of rapid fibrotic progression ( 36 ), and miR-192 might be one of the important biomarkers for disease evolution in MAFLD and DN.…”

Section: Discussionmentioning

confidence: 92%

Time for micro-RNAs in steatotic liver disease: a case–control study

Stoica,

Apostol,

Diculescu

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

One of the challenges of modern-day living is to resist the temptation of overfeeding and sedentariness and maintain a healthy body and mind. On a favorable genetic and epigenetic background, a high-fat diet combined with lack of physical exercise constitutes the foundation for severe metabolic disturbances including steatotic liver disease. In our case–control study, we had the aim of establishing the role of selected micro-RNAs—miR-122, miR-192, miR-33a, and miR-33b—as superior biomarkers for the diagnosis and prognosis of steatotic liver in a 36-patient cohort compared to 12 healthy controls. Initial results confirmed the decline in miR-122 expression as fatty liver is progressing. However, combinations of ΔmiRs, such as ΔmiR33a_192, ΔmiR33a_122, and ΔmiR33b_122, correlate with ultrasound steatosis grade (R2 = 0.78) while others such as ΔmiR33b_122 provide a high specificity and sensitivity in fatty liver disease with an area under the curve (AUC) of 0.85. Compared to classical biomarkers, micro-RNAs can be used for both diagnostic and prognostic purposes as their diminished expression in severe cases of steatosis is associated with higher risk of emerging hepatocellular carcinoma. Manipulating micro-RNAs through agomirs or antagomirs can be the answer to the yet unsolved problem of efficient therapy in MAFLD.

show abstract

Section: Discussionmentioning

confidence: 92%

Time for micro-RNAs in steatotic liver disease: a case–control study

Stoica,

Apostol,

Diculescu

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Promoting miR-29 signaling is found to weaken TGF-β1, fibronectin, and collagen I deposition in dystrophic musculoskeletal tissue [17,20]. Our investigation of transgenic mice overexpressing miR-29a uncovered that miR-29a overexpression enables animals to exhibit minor responses to fibrosis in diabetic kidneys [21,22], ligation-induced liver injury [23,24], and excess glucocorticoid-induced osteoporosis [25,26]. Of interest, treatment with non-coding RNA signaling becomes an innovative therapeutic strategy for excessive fibrosis in various tissues.…”

Section: Introductionmentioning

confidence: 88%

MicroRNA-29a Mitigates Laminectomy-Induced Spinal Epidural Fibrosis and Gait Dysregulation by Repressing TGF-β1 and IL-6

Lin

Lian

et al. 2023

IJMS

View full text Add to dashboard Cite

Spinal epidural fibrosis is one of the typical features attributable to failed back surgery syndrome, with excessive scar development in the dura and nerve roots. The microRNA-29 family (miR-29s) has been found to act as a fibrogenesis-inhibitory factor that reduces fibrotic matrix overproduction in various tissues. However, the mechanistic basis of miRNA-29a underlying the overabundant fibrotic matrix synthesis in spinal epidural scars post-laminectomy remained elusive. This study revealed that miR-29a attenuated lumbar laminectomy-induced fibrogenic activity, and epidural fibrotic matrix formation was significantly lessened in the transgenic mice (miR-29aTg) as compared with wild-type mice (WT). Moreover, miR-29aTg limits laminectomy-induced damage and has also been demonstrated to detect walking patterns, footprint distribution, and moving activity. Immunohistochemistry staining of epidural tissue showed that miR-29aTg was a remarkably weak signal of IL-6, TGF-β1, and DNA methyltransferase marker, Dnmt3b, compared to the wild-type mice. Taken together, these results have further strengthened the evidence that miR-29a epigenetic regulation reduces fibrotic matrix formation and spinal epidural fibrotic activity in surgery scars to preserve the integrity of the spinal cord core. This study elucidates and highlights the molecular mechanisms that reduce the incidence of spinal epidural fibrosis, eliminating the risk of gait abnormalities and pain associated with laminectomy.

show abstract

“…A plethora of evidence indicates that mechanisms such as autophagy, non-coding RNA, the gut microbiome, lipotoxicity, oxidative stress, and inflammatory responses contribute to DN ( Cui et al, 2020 ; Opazo-Ríos et al, 2020 ; Jin et al, 2023 ; Szostak et al, 2023 ; Zhao et al, 2023 ). Recent pharmacological studies have revealed that A. oxyphylla possesses therapeutic capabilities, including the activation of autophagy, regulation of non-coding RNA, modulation of intestinal microbiota, attenuation of lipotoxicity, reduction of oxidative damage, and mitigation of inflammatory responses ( Du et al, 2017 ; Xie et al, 2017 ; Xie et al, 2018 ; Wang et al, 2022 ; Wang et al, 2023c ; Ni et al, 2023 ; Yin et al, 2023 ).…”

Section: Roles Of Alpinia Oxyphylla On Dnmentioning

confidence: 99%

Research progress on Alpinia oxyphylla in the treatment of diabetic nephropathy

Wang,

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

Diabetic nephropathy (DN) constitutes a major microvascular complication of diabetes and is a primary cause of mortality in diabetic individuals. With the global rise in diabetes, DN has become an urgent health issue. Currently, there is no definitive cure for DN. Alpinia oxyphylla, a Chinese herbal medicine traditionally used, exhibits a wide range of pharmacological effects and is frequently used in the prevention and management of DN. This paper offers an extensive review of the biological mechanisms by which A. oxyphylla delivers therapeutic advantages in DN management. These mechanisms include activating podocyte autophagy, regulating non-coding RNA, modulating gut microbiota, alleviating lipotoxicity, counteracting oxidative stress, and diminishing inflammatory responses, underscoring the therapeutic potential of A. oxyphylla in DN treatment.

show abstract

The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy

Cited by 12 publications

References 121 publications

Time for micro-RNAs in steatotic liver disease: a case–control study

Time for micro-RNAs in steatotic liver disease: a case–control study

MicroRNA-29a Mitigates Laminectomy-Induced Spinal Epidural Fibrosis and Gait Dysregulation by Repressing TGF-β1 and IL-6

Research progress on Alpinia oxyphylla in the treatment of diabetic nephropathy

Contact Info

Product

Resources

About