The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Mirzaei, Sepideh; Zarrabi, Ali; Asnaf, Sholeh Etehad; Hashemi, Farid; Zabolian, Amirhossein; Hushmandi, Kiavash; Raei, Mehdi; Goharrizi, Mohammad Ali Sheikh Beig; Makvandi, Pooyan; Samarghandian, Saeed; Najafi, Masoud; Ashrafizadeh, Milad; Aref, Amir Reza; Hamblin, Michael R.

doi:10.1016/j.lfs.2020.119005

Cited by 58 publications

(24 citation statements)

References 212 publications

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“…Furthermore, chemotherapy may be followed by radiotherapy. 3,4 Immunotherapy and targeted cancer therapy are other newer antitumour therapy modalities. Immunotherapy aims to kill cancer cells by boosting immune system function.…”

Section: Introductionmentioning

confidence: 99%

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Yang

Najafi

2021

Basic Clin Pharma Tox

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Section: Introductionmentioning

confidence: 99%

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Yang

Najafi

2021

Basic Clin Pharma Tox

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“…Increasing lncRNAs have been found to be involved in the prevalent ceRNA networks, where they could compete with the upstream mediators of mRNAs, miRNAs, for the 3’UTR region of mRNAs, consequently regulating such mRNAs [ 27 , 28 ]. MiRNAs are a group of endogenous small ncRNAs that can modulate target gene expression at post-transcriptional level and capable of interaction with mRNA-coding genes [ 29 ]. Meanwhile, miRNA and lncRNA are key non-coding RNAs because of their negative feedback interaction and regulation on various biological processes by targeting diverse molecular pathways [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297

Liu

et al. 2021

Diagn Pathol

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Background Cervical cancer (CC) endangers women’s health in the world range. Accumulating studies have revealed the crucial regulatory role of long non-coding RNAs (lncRNAs) in multiple malignancies, including CC. Our study aimed to explore the role of lncRNA double homeobox A pseudogene 8 (DUXAP8) in cervical carcinogenesis. Methods Gene expressions in CC were assessed by RT-qPCR. Function experiments and tube formation assays were performed to evaluate the role of DUXAP8 in CC cells. Subcellular fractionation and FISH assays were conducted to determine the subcellular location of DUXAP8. Luciferase reporter, RNA pull down and RIP assays were conducted to investigate the mechanism of DUXAP8. Results DUXAP8 was notably upregulated in CC cells. Downregulation of DUXAP8 repressed cell malignant behaviors and angiogenesis in CC. Mechanically, DUXAP8 boosted the expression of reticulocalbin-2 (RCN2) through relieving the binding of miR-1297 to RCN2 3’-UTR. Moreover, miR-1297 inhibition and RCN2 overexpression could counteract the inhibitory effects of DUXAP8 knockdown on the malignant phenotypes of CC cells. Besides, enhanced RCN2 expression restored the tumor growth in vivo that was inhibited by DUXAP8 repression. Conclusions DUXAP8 promotes malignant behaviors in CC cells via regulating miR-1297/RCN2 axis. Graphical Abstract

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“…And the regulation of lncRNAs and miRNAs have also been reported in a variety of cancers (Dong et al, 2019;Xu et al, 2019;Ghafouri-Fard et al, 2021). MiRNAs, a kind of endogenous non-coding RNAs consisting of 21-23 nucleotide sequences, participate in the regulation of gene expression (Zamani et al, 2020;Mirzaei et al, 2021a). They control posttranscriptional regulatory factors of gene expression and the translation process of target mRNAs via attachment of mRNA molecules at the 3′-UTR bases, thus reducing transcription of proteins (Lagos-Quintana et al, 2001;Bartel, 2004;Pu et al, 2019;Alizadeh-Fanalou et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

miR-30d-5p: A Non-Coding RNA With Potential Diagnostic, Prognostic and Therapeutic Applications

Zhao

Yuan

Zheng

et al. 2022

Front. Cell Dev. Biol.

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Cancer is a great challenge facing global public health. Scholars have made plentiful efforts in the research of cancer therapy, but the results are still not satisfactory. In relevant literature, the role of miRNA in cancer has been widely concerned. MicroRNAs (miRNAs) are a non-coding, endogenous, single-stranded RNAs that regulate a variety of biological functions. The abnormal level of miR-30d-5p, a type of miRNAs, has been associated with various human tumor types, including lung cancer, colorectal cancer, esophageal cancer, prostate cancer, liver cancer, cervical cancer, breast cancer and other types of human tumors. This reflects the vital function of miR-30d-5p in tumor prognosis. miR-30d-5p can be identified either as an inhibitor hindering the development of, or a promoter accelerating the occurrence of tumors. In addition, the role of miR-30d-5p in cell proliferation, motility, apoptosis, autophagy, tumorigenesis, and chemoresistance are also noteworthy. The multiple roles of miR-30d-5p in human cancer suggest that it has broad feasibility as a biomarker and therapeutic target. This review describes the connection between miR-30d-5p and the clinical indications of tumors, and summarizes the mechanisms by which miR-30d-5p mediates cancer progression.

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The role of microRNA-338-3p in cancer: growth, invasion, chemoresistance, and mediators

Cited by 58 publications

References 212 publications

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Long non-coding RNA DUXAP8 elevates RCN2 expression and facilitates cell malignant behaviors and angiogenesis in cervical cancer via sponging miR-1297

miR-30d-5p: A Non-Coding RNA With Potential Diagnostic, Prognostic and Therapeutic Applications

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