The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer

Pordel, Safoora; Khorrami, Motahare; Saadatpour, Fatemeh; Rezaee, Delsuz; Cho, William C.; Jahani, Saleheh; Aghaei-Zarch, Seyed Mohsen; Hashemi, Elham; Najafi, Sajad

doi:10.1016/j.prp.2023.154729

Cited by 23 publications

(10 citation statements)

References 255 publications

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“…In vivo studies, particularly those utilizing animal models, have demonstrated that circRNAs influence tumor growth and metastasis ( 28 , 29 ). Moreover, akin to other ncRNAs such as miRNAs ( 30 , 31 ), circRNAs are emerging as vital prognostic and diagnostic biomarkers for a multitude of diseases such as neurologic diseases ( 32 ), diabetic complications ( 33 ) and tumors ( 34 ).…”

Section: Circrnamentioning

confidence: 99%

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

Ye,

Xiang,

Wang

et al. 2024

Int J Mol Med

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Circular RNA (circRNA), a type of non-coding RNA, plays a regulatory role in biological processes. The special loop structure of circRNA makes it highly stable and specific in diseased tissues and cells, especially in tumors. Competing endogenous RNAs (ceRNAs) compete for the binding of microRNA (miRNA) at specific binding sites and thus regulate gene expression. ceRNAs play an important role in various diseases and are currently recognized as the most prominent mechanism of action of circRNAs. circRNAs can modulate the proliferation, migration, invasion and apoptosis of tumor cells through the ceRNA mechanism. With further research, circRNAs may serve as novel markers and therapeutic targets for ovarian cancer (OC). In the present review, the research progress of circRNAs as ceRNAs in OC was summarized, focusing on the effects of the circRNA/miRNA/mRNA axis on the biological functions of OC cells through mediating pivotal signaling pathways. The role of circRNAs in the diagnosis, prognostic assessment and treatment of OC was also discussed in the present review.

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Section: Circrnamentioning

confidence: 99%

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

Ye,

Xiang,

Wang

et al. 2024

Int J Mol Med

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“…Among them, microRNA (miRNA), long ncRNA (lncRNA) and circular RNA (circRNA) are the major type ncRNAs that play a key role in cancers. 4 – 7 Circular RNAs (circRNAs), characterized by covalently closed-loop structures, have enormous advantages as noninvasive biomarkers of tumors due to their high stability and evolutionary conservation feature. 8 – 10 Recently, quite a lot of studies have revealed that circRNAs are involved in the malignant progression of cancer.…”

Section: Introductionmentioning

confidence: 99%

CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis

Luo,

Zhong,

Guo

et al. 2024

Technol Cancer Res Treat

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Objectives Circular RNAs (circRNAs) serve a crucial regulatory role in ovarian cancer (OC). Circular RNA ArfGAP with FG repeats 1 (circAGFG1) has been shown to be involved in promoting the progression of several cancers, containing triple-negative breast cancer, esophageal cancer and colorectal cancer. However, the function of circAGFG1 in OC is unclear. Methods Quantitative real-time reverse transcription PCR (RT-qPCR) was conducted to determine the expression levels of circAGFG1 and miR-409-3p. The proliferation and metastasis of cells were determined by colony formation assays, EdU assays, transwell assays and wound healing assays. In addition, a dual-luciferase reporter assay was performed to validate the mechanism between circAGFG1, miR-409-3p, and ZEB1. Results Our data suggested that circAGFG1 was significantly overexpressed in OC tissues compared to normal ovarian epithelial tissues. Overexpression of circAGFG1 was correlated with intraperitoneal metastasis, tumor recurrence and advanced stage. Additionally, circAGFG1 overexpression revealed a poor prognosis in OC patients. Knockdown of circAGFG1 suppressed the proliferation, invasion and migration of OC cells. Mechanistically, circAGFG1 acted as a sponge of miR-409-3p to enhance the expression level of zinc finger E-box binding homeobox 1 (ZEB1), thereby conferring OC cell proliferation, invasion and migration. Importantly, re-expression of ZEB1 effectively reversed the effects of circAGFG1 knockdown on OC cells. Conclusions In summary, our study indicated that circAGFG1 may act as a prognostic biomarker and potential therapeutic target for patients with OC.

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“…The advent of targeted therapies has markedly prolonged the survival of patients with mutations in key driver genes such as EGFR, ALK, MET, ROS1, RET, and HER2 [ 3 ]. Nevertheless, a significant fraction of LUAD patients do not possess these mutations, highlighting the critical need for identifying new actionable driver genes [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis

Yu,

Wang

et al. 2024

J Transl Med

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Background Chaperonin Containing TCP1 Subunit 6 A (CCT6A) is a prominent protein involved in the folding and stabilization of newly synthesized proteins. However, its roles and underlying mechanisms in lung adenocarcinoma (LUAD), one of the most aggressive cancers, remain elusive. Methods Our study utilized in vitro cell phenotype experiments to assess CCT6A’s impact on the proliferation and invasion capabilities of LUAD cell lines. To delve into CCT6A’s intrinsic mechanisms affecting glycolysis and proliferation in lung adenocarcinoma, we employed transcriptomic sequencing and liquid chromatography-mass spectrometry analysis. Co-immunoprecipitation (Co-IP) and chromatin immunoprecipitation (CHIP) assays were also conducted to substantiate the mechanism. Results CCT6A was found to be significantly overexpressed in LUAD and associated with a poorer prognosis. The silencing of CCT6A inhibited the proliferation and migration of LUAD cells and elevated apoptosis rates. Mechanistically, CCT6A interacted with STAT1 protein, forming a complex that enhances the stability of STAT1 by protecting it from ubiquitin-mediated degradation. This, in turn, facilitated the transcription of hexokinase 2 (HK2), a critical enzyme in aerobic glycolysis, thereby stimulating LUAD’s aerobic glycolysis and progression. Conclusion Our findings reveal that the CCT6A/STAT1/HK2 axis orchestrated a reprogramming of glucose metabolism and thus promoted LUAD progression. These insights position CCT6A as a promising candidate for therapeutic intervention in LUAD treatment.

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The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer

Cited by 23 publications

References 255 publications

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

Role of circular RNA as competing endogenous RNA in ovarian cancer (Review)

CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis

CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis

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