The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells

Masri, Selma; Liu, Zheng; Phung, Sheryl; Wang, Emily; Yuan, Yate-Ching; Chen, Shiuan

doi:10.1007/s10549-009-0716-3

Cited by 94 publications

(63 citation statements)

References 43 publications

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“…Association analyses revealed that expression of mir-205 and mir-21 are markers linked to squamous cell carcinoma (SCC) and adenocarcinoma (ADC) histology, respectively, confirming previous studies on the validity of studying miRNA expression in support of histopathological diagnosis for a precise classification of tumor histology (20)(21)(22). Interestingly, miRNAs that were deregulated in the more aggressive tumors identified in later years of screening are involved in adhesion and invasion pathways: miR-339 was reported to negatively regulate intercellular cell adhesion molecule (ICAM)-1 (23), and mir-128a has been involved in TGFβ pathway promotion of tumor cell invasion and metastasis (24). This miRNA specifically targets FOXO1A, a transcription factor involved in AKT signaling and apoptosis inhibition (25).…”

Section: Discussionsupporting

confidence: 79%

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

Boeri

Verri

Conte

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

629

565

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The efficacy of computed tomography (CT) screening for early lung cancer detection in heavy smokers is currently being tested by a number of randomized trials. Critical issues remain the frequency of unnecessary treatments and impact on mortality, indicating the need for biomarkers of aggressive disease. We explored microRNA (miRNA) expression profiles of lung tumors, normal lung tissues and plasma samples from cases with variable prognosis identified in a completed spiral-CT screening trial with extensive follow-up. miRNA expression patterns significantly distinguished: (i) tumors from normal lung tissues, (ii) tumor histology and growth rate, (iii) clinical outcome, and (iv) year of lung cancer CT detection. Interestingly, miRNA profiles in normal lung tissues also displayed remarkable associations with clinical features, suggesting the influence of a permissive microenvironment for tumor development. miRNA expression analyses in plasma samples collected 1-2 y before the onset of disease, at the time of CT detection and in disease-free smokers enrolled in the screening trial, resulted in the generation of miRNA signatures with strong predictive, diagnostic, and prognostic potential (area under the ROC curve ≥ 0.85). These signatures were validated in an independent cohort from a second randomized spiral-CT trial. These results indicate a role for miRNAs in lung tissues and plasma as molecular predictors of lung cancer development and aggressiveness and have theoretical and clinical implication for lung cancer management.circulating biomarkers | risk prediction | miRNA ratios D espite recent advances in the management of resected lung cancer and the use of molecular targeted agents in specific clinical settings, the cure rate of non-small-cell lung cancer (NSCLC) remains low due to drug-refractory recurrent and metastatic disease.Early detection studies using chest X-rays (1) and, more recently, spiral-computed tomography (CT; refs. 2 and 3), have reported a significant increase in the number of lung cancer diagnoses, without apparent major decrease in advanced cancers or reduction of mortality in smokers (4). A recent press release (http://www.cancer.gov) reporting the findings of the largest randomized trial comparing spiral-CT to chest X-rays showed a 6.9% reduction in all-cause mortality (−20.3% lung cancer mortality), but a full report of the results of this trial is not yet available. A likely explanation of the limited impact of CT screening on mortality is that perhaps not all aggressive lung tumors arise from identifiable slow-growing precursors, suggesting a possible paradigm shift in our understanding of the natural history of lung cancer (5, 6). In this respect, the identification of biologic and molecular features of indolent and aggressive disease would be critical to define clinically useful predictors of high-risk lesions. microRNAs (miRNAs) are small RNA molecules with regulatory function and marked tissue specificity that can modulate multiple targets belonging to several pathways. They are fr...

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Section: Discussionsupporting

confidence: 79%

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

Boeri

Verri

Conte

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

629

565

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“…The mechanism of TGF␤1 sensitivity loss in T ϩ LET R cells was suggested to result from miR-128a targeting TGF␤R1 protein expression. This study concluded that breast cancer progression and resistance to therapy, owing to the modulation of vital signaling pathways, may be due not only to estrogen-mediated gene expression, but also to hormone-regulated miRNAs (68 ).…”

Section: Mir-224mentioning

confidence: 91%

Intracellular and Extracellular MicroRNAs in Breast Cancer

et al. 2011

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BACKGROUND Successful treatment of breast cancer is enhanced by early detection and, if possible, subsequent patient-tailored therapy. Toward this goal, it is essential to identify and understand the most relevant panels of biomarkers, some of which may also have relevance as therapeutic targets. METHODS We critically reviewed published literature on microRNAs (miRNAs) as relevant to breast cancer. SUMMARY Since the initial recognition of the association of miRNAs with breast cancer in 2005, studies involving cell lines, in vivo models, and clinical specimens have implicated several functions for miRNAs, including suppressing oncogenesis and tumors, promoting or inhibiting metastasis, and increasing sensitivity or resistance to chemotherapy and targeted agents in breast cancer. For example, miR-21 is overexpressed in both male and female breast tumors compared with normal breast tissue and has been associated with advanced stage, lymph node positivity, and reduced survival time. miR-21 knock-down in cell-line models has been associated with increased sensitivity to topotecan and taxol in vitro and the limitation of lung metastasis in vivo. Furthermore, the discovery of extracellular miRNAs (including miR-21), existing either freely or in exosomes in the systemic circulation, has led to the possibility that such molecules may serve as biomarkers for ongoing patient monitoring. Although additional investigations are necessary to fully exploit the use of miRNAs in breast cancer, there is increasing evidence that miRNAs have potential not only to facilitate the determination of diagnosis and prognosis and the prediction of response to treatment, but also to act as therapeutic targets and replacement therapies.

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“…miRNAs are also associated with resistance to aromatase inhibitors. 60 Masri et al 61 suggested that miR-128a modulates the transforming growth factor-β signaling and survival of letrozole-resistant cell lines. miRNAs expression profiling before and after letrozole treatment reveal post-treatment increases in let-7f expression in both the preclinical and clinical settings.…”

Section: Mirna In Hormone Receptor-positive/her2-negative Breast Cancermentioning

confidence: 99%

Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes

et al. 2016

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MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes at the post-transcriptional phase. miRNAs are considered to have roles in the development, progression and metastasis of cancer. Recent studies have indicated that particular miRNA signatures are correlated with tumor aggressiveness, response to drug therapy and patient outcome in breast cancer. On the other hand, in routine clinical practice, the treatment regimens for breast cancer are determined based on the intrinsic subtype of the primary tumor. Previous studies have shown that miRNA expression profiles of each intrinsic subtypes of breast cancer differ. In hormone receptor-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer, miRNA expressions are found to be correlated with endocrine therapy resistance, progesterone receptor expression and heat shock protein activity. Some miRNAs are associated with resistance to HER2-targeted therapy and HER3 expression in HER2-positive breast cancer. In triple-negative breast cancer, miRNA expressions are found to be associated with BRCA mutations, immune system, epithelial-mesenchymal transition, cancer stem cell properties and androgen receptor expression. As it has been clarified that the expression levels and functions of miRNA differ among the various subtypes of breast cancer, and it is necessary to take account of the characteristics of each breast cancer subtype during research into the roles of miRNA in breast cancer. In addition, the discovery of the roles played by miRNAs in breast cancer might provide new opportunities for the development of novel strategies for diagnosing and treating breast cancer.

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The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells

Cited by 94 publications

References 43 publications

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer

Intracellular and Extracellular MicroRNAs in Breast Cancer

Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes

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