The Role of Micronutrients to Support Immunity for COVID-19 Prevention

Ahmed, Mukhtar H.; Hassan, Arez; Molnár, Judit

doi:10.1007/s43450-021-00179-w

Cited by 21 publications

(26 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The recent experimental studies described that a lack of micro-and macronutrients in terms of quality and/or quantity in the diet of SARS-CoV-2-infected patients increases the morbidity and mortality rates [51]. Nevertheless, the intake of seaweeds as dietary supplements may provide the essential micronutrients, reducing the risk of omicron infections and organ deterioration [52,53]. The chemical compounds from the dietary seaweeds, particularly constituted with fucoidan, might have antiviral actions against SARS-CoV-2 [54].…”

Section: Discussionmentioning

confidence: 99%

In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer

et al. 2022

View full text Add to dashboard Cite

Omicron is an emerging SARS-CoV-2 variant, evolved from the Indian delta variant B.1.617.2, which is currently infecting worldwide. The spike glycoprotein, an important molecule in the pathogenesis and transmissions of SARS-CoV-2 variants, especially omicron B.1.1.529, shows 37 mutations distributed over the trimeric protein domains. Notably, fifteen of these mutations reside in the receptor-binding domain of the spike glycoprotein, which may alter transmissibility and infectivity. Additionally, the omicron spike evades neutralization more efficiently than the delta spike. Most of the therapeutic antibodies are ineffective against the omicron variant, and double immunization with BioNTech-Pfizer (BNT162b2) might not adequately protect against severe disease induced by omicron B.1.1.529. So far, no efficient antiviral drugs are available against omicron. The present study identified the promising inhibitors from seaweed’s bioactive compounds to inhibit the omicron variant B.1.1.529. We have also compared the seaweed’s compounds with the standard drugs ceftriaxone and cefuroxime, which were suggested as beneficial antiviral drugs in COVID-19 treatment. Our molecular docking analysis revealed that caffeic acid hexoside (−6.4 kcal/mol; RMSD = 2.382 Å) and phloretin (−6.3 kcal/mol; RMSD = 0.061 Å) from Sargassum wightii (S. wightii) showed the inhibitory effect against the crucial residues ASN417, SER496, TYR501, and HIS505, which are supported for the inviolable omicron and angiotensin-converting enzyme II (ACE2) receptor interaction. Cholestan-3-ol, 2-methylene-, (3beta, 5 alpha) (CMBA) (−6.0 kcal/mol; RMSD = 3.074 Å) from Corallina officinalis (C. officinalis) manifested the strong inhibitory effect against the omicron RBD mutated residues LEU452 and ALA484, was magnificently observed as the essential residues in Indian delta variant B.1.617.2 previously. The standard drugs (ceftriaxone and cefuroxime) showed no or less inhibitory effect against RBD of omicron B.1.1.529. The present study also emphasized the pharmacological properties of the considered chemical compounds. The results could be used to develop potent seaweed-based antiviral drugs and/or dietary supplements to treat omicron B.1.1529-infected patients.

show abstract

Section: Discussionmentioning

confidence: 99%

In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Zn, vitamin D, vitamin C, curcumin, cinnamaldehyde, probiotics, selenium, lactoferrin, quercetin, and other nutrients are among them. Combining some of these phytonutrients in the right combination as a food supplement may help to boost the immune system, prevent virus spread, prevent disease progression to a severe stage, and suppress hyper inflammation even further, providing both prophylactic and therapeutic support against COVID-19 ( Mrityunjaya et al., 2020 ; Ahmed et al., 2021 ). Micronutrients stimulate the immune system and can be used as a treatment for those who do not want to use drugs.…”

Section: Prevention Of Covid-19 and Immune Enhancermentioning

confidence: 99%

In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective

Rahman

Islam

Akash

et al. 2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a substantial number of deaths around the world, making it a serious and pressing public health hazard. Phytochemicals could thus provide a rich source of potent and safer anti-SARS-CoV-2 drugs. The absence of approved treatments or vaccinations continues to be an issue, forcing the creation of new medicines. Computer-aided drug design has helped to speed up the drug research and development process by decreasing costs and time. Natural compounds like terpenoids, alkaloids, polyphenols, and flavonoid derivatives have a perfect impact against viral replication and facilitate future studies in novel drug discovery. This would be more effective if collaboration took place between governments, researchers, clinicians, and traditional medicine practitioners’ safe and effective therapeutic research. Through a computational approach, this study aims to contribute to the development of effective treatment methods by examining the mechanisms relating to the binding and subsequent inhibition of SARS-CoV-2 ribonucleic acid (RNA)-dependent RNA polymerase (RdRp). The in silico method has also been employed to determine the most effective drug among the mentioned compound and their aquatic, nonaquatic, and pharmacokinetics’ data have been analyzed. The highest binding energy has been reported -11.4 kcal/mol against SARS-CoV-2 main protease (7MBG) in L05. Besides, all the ligands are non-carcinogenic, excluding L04, and have good water solubility and no AMES toxicity. The discovery of preclinical drug candidate molecules and the structural elucidation of pharmacological therapeutic targets have expedited both structure-based and ligand-based drug design. This review article will assist physicians and researchers in realizing the enormous potential of computer-aided drug design in the design and discovery of therapeutic molecules, and hence in the treatment of deadly diseases.

show abstract

“…All of these immunocompromised conditions are liable to be influenced not only by COVID-19 infections but also by other pathogens and can lead to fatal consequences. A variety of approaches have targeted immune boosting with vitamins, especially D, C, and E, for patients who are suffering from acute respiratory distress syndromes and other symptoms in conjunction with COVID-19 [ 18 , 43 ]. Accordingly, the immune system is a major focus of modern medicine, which functions as the principle means of prevention for various diseases.…”

Section: Functional Importance Of the Immune System And Its Connectio...mentioning

confidence: 99%

“…The protective effects of retinoids on a number of viruses, including hepatitis B, influenza, and cytomegalovirus, have been demonstrated [ 41 , 46 ]. Vitamin A deficiency has been shown to be correlated with COVID-19 incidence and mortality [ 18 ]. It has been reported that retinoic acid agonist acts on SARS and MERS through the interruption of lipogenic pathways [ 18 , 47 ], which could be used in combination with other antiviral drugs in the management of COVID-19 or other viral infections.…”

Section: Vitamin and Immune Health Dynamics In Healthy Physiologymentioning

confidence: 99%

“…Since no therapies are effective to prevent and/or cure this deadly disease today, healthy diet and/or lifestyle, involving modulation of the immune system, is pivotal to combating COVID-19. Even so, the COVID-19 pandemic, impacting infections and mortalities worldwide, has prompted the development and urgent approval of a number of measures, including vaccinations and medications [ 17 , 18 ]. Currently, a few anti-viral drugs and antibody cocktails have received emergency use authorization (EUA) to respond to and/or treat certain COVID-19 patients to reduce hospitalizations, as well as mortalities [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Healthy Immunity on Preventive Medicine for Combating COVID-19

2022

View full text Add to dashboard Cite

Immunomodulation is influenced by the consumption of nutrients, and healthy immunity is pivotal to defending an individual from a variety of pathogens. The immune system is a network of intricately regulated biological processes that is comprised of many organs, cellular structures, and signaling molecules. A balanced diet, rich in vitamins, minerals, and antioxidants, is key to a strengthened immune system and, thus, crucial to proper functioning of various physiological activities. Conversely, deficiencies of these micronutrients, involving impaired immunity, are linked to numerous health complications, along with a host of pathologies. Coronavirus disease 2019 (COVID-19) is a dangerous infectious disease caused by a β-form of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its genomic variants, which enter host cells upon binding to the angiotensin converting enzyme 2 receptors, and is associated with substantial morbidities and mortalities globally. Patients afflicted with COVID-19 display asymptomatic to severe symptoms, occurrences of which are multifactorial and include diverse immune responses, sex and gender differences, aging, and underlying medical conditions. Geriatric populations, especially men in comparison to women, regardless of their states, are most vulnerable to severe COVID-19-associated infections and complications, with fatal outcomes. Advances in genomic and proteomic technologies help one understand molecular events, including host–pathogen interactions and pathogenesis of COVID-19 and, subsequently, have developed a variety of preventive measures urgently, ranging from mask wearing to vaccination to medication. Despite these approaches, no unique strategy is available today that can effectively prevent and/or treat this hostile disease. As a consequence, the maintenance of a boosted immune system could be considered a high priority of preventive medicine for combating COVID-19. Herein, we discuss the current level of understanding underlining the contribution of healthy immunity and its relevance to COVID-19 molecular pathogenesis, and potential therapeutic strategies, in the management of this devastating disease.

show abstract

The Role of Micronutrients to Support Immunity for COVID-19 Prevention

Cited by 21 publications

References 97 publications

In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer

In Silico Screening of Bioactive Compounds of Representative Seaweeds to Inhibit SARS-CoV-2 ACE2-Bound Omicron B.1.1.529 Spike Protein Trimer

In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspective

Healthy Immunity on Preventive Medicine for Combating COVID-19

Contact Info

Product

Resources

About