The Role of Microelectrode Recording (MER) in STN DBS Electrode Implantation

Raju, Venkateshwarla Rama; Rukmini, K M; Borgohain, Rupam; Ankathi, P.; Anitha,; Jabeen, Shagufta; Meena, A K

doi:10.1007/978-3-319-19387-8_292

Cited by 5 publications

(2 citation statements)

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“…[4][5][6][7][8][9] Unlike MER-SNA, macro electrode recordings are based on local field potentials which represent the aggregate activity of neuronal populations in the region of the electrode contact. [7][8][9][10] In PD, LFP recordings from STN are an important indicator of neural rhythms. 8 Studies have demonstrated an excessive synchrony in beta band (13Hz-30Hz) activity in STN.…”

Section: Introductionmentioning

confidence: 99%

“…8 Studies have demonstrated an excessive synchrony in beta band (13Hz-30Hz) activity in STN. [9][10][11][12][13][14][15] The aim of the present study was to explore the informational content of local field potential's L F Ps recorded from macro-D B S electrodes, in order to identify the anatomical borders of S T N. Since the L F Ps can easily be recorded from macro contacts, their use in the operating room can reduce surgery time and serve as a useful tool for target confirmation or validation.…”

Section: Introductionmentioning

confidence: 99%

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Edge detections of MER Signals of STN with DBS micro electrode local field potential acquisitions in Parkinson`s

Raju

2022

IJN

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Deep brain stimulation of the subthalamic nucleus (STN) is a highly effective treatment for motor symptoms of Parkinson’s disease. Sub thalamic nucleus deep brain stimulation (STN-DBS) is a therapeutic surgical procedure for reducing the symptoms Parkinson’s and restoring and increasing the motor functioning. However, precise intraoperative edge or perimeter detection of STN remains a procedural challenge. In this study, we present the micro electrode signals recordings (MER) of STNs and local field potentials (LFPs) were acquired from deep brain stimulation macro electrodes during trajectory towards STN, in Parkinson patients. The frequency versus intensity atlas of field potential activity was obtained and further than investigated in distinct sub band’s, to explore whether field potentials activity can be employed for STN edge detection. STN perimeter detections by means of L F Ps were evaluated to edge predictions by way of the functional stereotactic DBS neurosurgeon, based on micro electrode derived, single unit recordings (M E R – S N A of S T Ns). The findings show variation amongst M E R – S N A and macro electrode L F P-signals gathering through MER-system pertaining to the d o r s a l S T N b o r d e r of -1.00±0.85mm plus -0.42±1.08 mm in the and frequencies, correspondingly. For these sub band`s, root mean square of the voids was found to be 1.27milli meters and 1.07milli meters. The Assessment of other sub band`s didn`t set a limit for differentiating the posterior (c a u d a l) point of sub-thalamic nuclei. We may infer that In conclusion, macro electrode signal acquisitions of STNs derived L F P gatherings might offer an unconventional methodology in the direction of m e r – s n a, for detecting the aimed target subthalamic nucleus borders during DBS-surgery.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Edge detections of MER Signals of STN with DBS micro electrode local field potential acquisitions in Parkinson`s

Raju

2022

IJN

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Effect of Microelectrode Recording in Accurate Targeting STN with High Frequency DBS in Parkinson Disease

Raju

Mridula

Borgohain

2019

IETE Journal of Research

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Analysis of Parkinson‘s disease movement disorder by M E R with S T N – Deep Brain Stimulations

Raju¹

2021

IJN

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Brain's neuro protection is clearly the new frontier in movement disorder research and therapy. The longterm clinical studies have so far failed to prove that high-frequency stimulation has been able to slow down the evolution of the disease. So called e a r l y s t i m clinical p r o t o c o l s have only proven that it was safe to induce or stimuli sub thalamic nucleus S T N much earlier than it was so far accepted. At the experimental level, M P T P-treated monkeys, high-frequency stimuli of the S T N could protect neurons in the sub stantia nigra. To test this scientific rationale/hypothesis in humans, one would need to perform S T N induced stimuli at the very beginning of the disease, which is not easily ethically sustainable given the surgical risk, even if low, in patients who are still minimally impaired by the disease. There have been so many advancements in computing capabilities; big data management; miniaturization of electronics, devices and batteries; and new sources of energy compatible with implantation of biological devices and fuel cells. More recently, there has been an explosion of biological imaging at the nano level as well as whole-brain imaging. It is impossible to generate a reasonable picture of future technological development without being sure to be wrong. The consequence of that is that when building projects and setting new protocols as well as imagining new tools and devices, we should be confident that what has not yet been developed will eventually be created. In this article we the author explained the present past and future Parkinson's disease prediction.

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The Role of Microelectrode Recording (MER) in STN DBS Electrode Implantation

Cited by 5 publications

References 0 publications

Edge detections of MER Signals of STN with DBS micro electrode local field potential acquisitions in Parkinson`s

Edge detections of MER Signals of STN with DBS micro electrode local field potential acquisitions in Parkinson`s

Effect of Microelectrode Recording in Accurate Targeting STN with High Frequency DBS in Parkinson Disease

Analysis of Parkinson‘s disease movement disorder by M E R with S T N – Deep Brain Stimulations

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