The Role of Microbial Amino Acid Metabolism in  Host Metabolism

Neis, Evelien P. J. G.; Dejong, Cornelis H. C.; Rensen, Sander S.

doi:10.3390/nu7042930

Cited by 688 publications

(573 citation statements)

References 108 publications

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“…In particular, the functional output of the gut microbiota, including short-chain fatty acids (SCFAs), amino acids, and secondary biliary acids, is thought to modulate the pathogenesis of obesity (146). The known roles of some metabolites in immune cell function support their possible involvement in modulating alloimmunity.…”

Section: R E V I E W S E R I E S : T R a N S P L A N Tat I O Nmentioning

confidence: 99%

Impact of environmental factors on alloimmunity and transplant fate

Riella

Bagley

Iacomini

et al. 2017

Journal of Clinical Investigation

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Section: R E V I E W S E R I E S : T R a N S P L A N Tat I O Nmentioning

confidence: 99%

Impact of environmental factors on alloimmunity and transplant fate

Riella

Bagley

Iacomini

et al. 2017

Journal of Clinical Investigation

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“…Mostly intercellular lipid intermediates, sphingolipids and bile acid intermediates are associated to obesity [77]. Microbial metabolism produces SCFAs from host amino acids, and changes in plasma levels of some amino acids are associated with T2DM [79], particularly aromatic amino acids. In a Qatari study, predictors of T2DM were identified in different body fluids, saliva, plasma, and urine, at different timescales of glycemic control, revealing a connection between metabolites across the body fluids and a specific association of metabolites with the timescales of glycemic control [44].…”

Section: Nutrigenomic Approaches To Obesitymentioning

confidence: 99%

Potential Nutrigenomic Approaches to Reduce the High Incidence of Obesity in Qatar

Soldati¹,

Tomei²

2016

J Nutr Food Sci

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Obesity prevalence has been growing exponentially over the last few decades, with a high impact in high-income countries, like Qatar. Several approaches are attempting to understand the causes of this phenomenon however more important is what to do to reverse the trends. Obesity is widely studied, mostly in Europe and the Unites States, and a number of studies have demonstrate the role of specific gene patterns, transcriptome and proteome pathways, and gut microbiome strains. The Omics sciences have a great potential to investigate the determinants of non-communicable diseases, such as obesity. Nutritional genomics sciences apply all the Omics approaches to address nutrition-related diseases, investigating the interaction between genes and diet. To date, few data are available from nutrigenomic studies conducted in Middle East and particularly in Qatar to help the design of targeted interventions. The high incidence of obesity and the peculiar genetic make-up of the Qatari population provide opportunities for exploring nutrigenomic approaches to help addressing the problem.

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“…Bacteria of the rumen may be incorporated straight into amino acids and peptides from the diet [5]. Consequently, there is need to consider the proportion of peptides and amino acids in dairy cow rations.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Yield of Microbial-N from Fermentation of Glucogenic and Lipogenic Diets Provided by Different Sources of Rumen Degradable Amino Acids

Eyni¹,

Mesgaran²,

Vakili³

et al. 2017

J Vet Sci Technol

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This experiment was conducted to evaluate the effects of different sources of rumen degradable amino acids, soybean meal versus a commercial source of hydrolyzed cottonseed cake with low molecular weight (Fortid ® ), on the in vitro ruminal fermentation responses and the microbial nitrogen yield of glucogenic (n=8) and lipogenic (n=8) diets. An in vitro gas production technique was used to determine the differences in microbial nitrogen yield of the diets. Sources of grain including barely and corn were used in the glucogenic diets as grinded or steam flaked, while in the lipogenic diets, corn silage, sugar beet pulp, linseed and prill fat were used to provide the energy needed for rumen fermentation. The experiment was a randomized design including two types of diets × two sources of rumen degradable amino acids factorial arrangement. The gas produced from the fermentable fraction (b) was higher for the lipogenic diets containing corn silage and F than those for the others. The fraction (b) and microbial nitrogen to diet nitrogen ratio were greater (p<0.05) for Fortid ® versus soybean meal. The true substrate digestibility of glucogenic diets were significantly higher (p<0.05) compared to those of lipogenic diets. Both the grain sources used as steam flaked caused an increase in the rate of gas produced (c) and microbial nitrogen to diet nitrogen ratio. There were significant interactions (p<0.005) of the type of diets with either soybean meal or Fortid ® on microbial nitrogen to diet nitrogen. The results indicated that pre-hydrolyzed protein sources which are rich in low molecular weight peptides may be considered as candidates to improve rumen feed fermentation and microbial nitrogen production with both glucogenic and lipogenic diets. This conclusion was arrived at from the different patterns of action of soybean meal and Fortid ® in the present in vitro rumen fermentation responses.

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The Role of Microbial Amino Acid Metabolism in Host Metabolism

Cited by 688 publications

References 108 publications

Impact of environmental factors on alloimmunity and transplant fate

Impact of environmental factors on alloimmunity and transplant fate

Potential Nutrigenomic Approaches to Reduce the High Incidence of Obesity in Qatar

In Vitro Yield of Microbial-N from Fermentation of Glucogenic and Lipogenic Diets Provided by Different Sources of Rumen Degradable Amino Acids

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