2022
DOI: 10.30699/ijp.2022.539029.2726
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The Role of Micro RNAs in Regulating PI3K/AKT Signaling Pathways in Glioblastoma

Abstract: Glioblastoma is a type of brain cancer with aggressive and invasive nature. Such features result from increased proliferation and migration and also poor apoptosis of glioma cells leading to resistance to current treatments such as chemotherapy and radiotherapy. In recent studies, micro RNAs have been introduced as a novel target for treating glioblastoma via regulation of apoptotic signaling pathway, remarkably PI3K/AKT, which affect cellular functions and blockage or progression of the tumor. In this review,… Show more

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Cited by 5 publications
(2 citation statements)
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“…Specifically, several oncogenic miRNAs that are overexpressed in ER+ breast cancer directly target the tumor suppressor PTEN, which dephosphorylates PIP3 and subsequently suppresses PI3K/Akt signaling ( Figure 3 ). Therefore, the abnormal overexpression of oncogenic miRNAs in ER+ breast cancer attenuates PTEN-mediated inhibition of PI3K/Akt signaling, which in turn increases oncogenic cell growth, survival, and migration through downstream Akt signaling ( 33 ). For patients with ER+ breast cancer, targeted inhibition of these oncogenic miRNAs may offer additional therapeutic alternatives.…”
Section: Oncogenic Mirnas In Bcmentioning
confidence: 99%
“…Specifically, several oncogenic miRNAs that are overexpressed in ER+ breast cancer directly target the tumor suppressor PTEN, which dephosphorylates PIP3 and subsequently suppresses PI3K/Akt signaling ( Figure 3 ). Therefore, the abnormal overexpression of oncogenic miRNAs in ER+ breast cancer attenuates PTEN-mediated inhibition of PI3K/Akt signaling, which in turn increases oncogenic cell growth, survival, and migration through downstream Akt signaling ( 33 ). For patients with ER+ breast cancer, targeted inhibition of these oncogenic miRNAs may offer additional therapeutic alternatives.…”
Section: Oncogenic Mirnas In Bcmentioning
confidence: 99%
“…However, the connections involving other ncRNAs, such as between miRNAs and AKT/AKT signaling, lack comprehensive and systemic integration. Recently, the impact of miRNAs in the regulation of AKT signaling has been reported in several cancer studies, such as for breast [ 35 ], glioblastoma [ 36 ], and nasopharyngeal [ 37 ] cancer cells. Moreover, miRNA and AKT signaling exhibit a reciprocal interaction in cancer cells [ 38 ].…”
Section: Relationship Between Mirna Akt and Cell Functionsmentioning
confidence: 99%