The role of metformin and statins in the incidence of epithelial ovarian cancer in type 2 diabetes: a cohort and nested case–control study

Abstract

No evidence found for metformin or statins reducing the incidence of ovarian cancer.

Do statins play role in reducing the incidence and mortality of ovarian cancer? A systematic review and meta-analysis

“…After the study of the finally enrolled 24 articles, two other studies were excluded because the effect size of statin on the incidence or mortality of OC had not been calculated or not been reported in the study and four studies were found as being irrelevant to my research according to the information of the full texts of the articles. Eighteen articles were selected for final analysis, of which ten articles were included for the assessment of the relationship between statin use and the risk of developing OC [ 11 , 12 , 16-18 , 22 , 23 , 32-34 ], and nine articles for the relationship between post-diagnosis statin consumption and OC mortality [ 11 , 13-15 , 19-21 , 35 , 36 ]. It should be noted that Lavie et al study [ 11 ], addressed both the risk of incidence and mortality of from OC ( Fig.…”

“…There were 7,943 cases of OC incidence reported in the included studies. Among the studies included [ 11 , 12 , 16-18 , 22 , 23 , 32-34 ], four studies were cohort studies with total sample size of 428,613 individuals [ 17 , 22 , 33 , 34 ], five studies were case-control with total sample size equal to 82,4891 individuals [ 11 , 12 , 16 , 18 , 32 ] and one was a clinical trial with total sample size equal to 997 individuals [ 23 ].…”

“…The reviewed articles had been published between 2001-2018 Six of the included studies were conducted in USA [ 12 , 17 , 22 , 23 , 33 , 34 ], three in Europe [ 16 , 18 , 32 ] and one in Asia [ 11 ]. The sample size was 682-748, 282 participants and the mean follow-up of the participants period was 59-130 months ( Tab.…”

“…This meta-analysis included ten studies investigating the association between statin consumption and the risk of developing OC [ 11 , 12 , 16-18 , 22 , 23 , 32-34 ]. Adjusted variables in the assessment of the relationship between statin use and risk of OC incidence are shown in Table II .…”

“…Recent studies have reported that statin could reduce the risk of OC incidence [ 11 , 12 ] and also its post-diagnosis use can improve the survival of OC patients [ 11 , 13-15 ]. In contrast, some studies have not reported any strong evidence on the protective effect of statins in reducing the risk of incidence [ 16-18 ] and mortality from OC [ 19-21 ].…”