The role of metallothionein and selenium in metal detoxification in the liver of deep-sea fish from the NW Mediterranean Sea

Siscar, R.; Koenig, Samuel; Torreblanca, Amparo; Solé, Montserrat

doi:10.1016/j.scitotenv.2013.07.081

Cited by 64 publications

(33 citation statements)

References 54 publications

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“…Regarding to the enhancement of liver protection by DOW, DOW has intrinsic hepatoprotective functions (Ha et al 2014;Siscar et al 2014). In the previous study, the submerged culture consists of DOW as the main water source; therefore, the functional ingredients of DOW were accumulated in the A. camphorata mycelium and fermentation filtrates (Wang et al 2013a).…”

Section: Increasing Functional Metabolite Productionmentioning

confidence: 99%

“…Additionally, DOW substantially reduced TAA-induced TNF-α and α-SMA expression levels and collagen production abilities (Wang et al 2013a). Previous studies have demonstrated the antiinflammatory and hepatoprotective effects of DOW (Ha et al 2014;Siscar et al 2014). Therefore, the hepatoprotective effects of DOW were accumulated in DOW-AC, which enhanced preventive effects against liver fibrosis (Wang et al 2013a).…”

Section: Increasing Functional Metabolite Productionmentioning

confidence: 99%

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The advantages of deep ocean water for the development of functional fermentation food

Lee¹

2015

Appl Microbiol Biotechnol

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Deep ocean water (DOW) is obtained from 600 m below the sea surface. In recent years, DOW has been applied in the development of fermentation biotechnologies and functional foods. DOW is rich in trace minerals, comprises multiple physiological and health functions, and is able to promote microbe growth; therefore, the application of DOW directly benefits the development of the fermentation industry and functional foods. This study integrated the current health functions and applications of DOW with the latest results from studies related to fermentation biotechnology. Subsequently, the influence of applying DOW in fermented functional food development and the effects in health function improvements were summarized. According to the previous studies, the main reasons for the increased effect of fermented functional foods through the application of DOW are increased generation of functional metabolite contents in the microbes, intrinsic health functions of DOW, and the microbial use of mechanisms of converting the absorbed inorganic ions into highly bioavailable organic ions for the human body. These combined advantages not only enhance the health functions of fermentation products but also provide fermentation products with the intrinsic health functions of DOW.

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Section: Increasing Functional Metabolite Productionmentioning

confidence: 99%

Section: Increasing Functional Metabolite Productionmentioning

confidence: 99%

The advantages of deep ocean water for the development of functional fermentation food

Lee¹

2015

Appl Microbiol Biotechnol

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“…All the phenomena could be elucidated by chemical property of the thiolate bond (Suzuki et al, 2002). Some deep-sea fish species like Alepocephalus rostratus sequester heavy metals like Hg and Ag bound to MT under the synergy effects of Se (Siscar et al, 2014). Caretta caretta and Chelonia mydas also secretes mucus containing MT proteins that decrease Cu and Cd concentrations in hepatic and renal (Andreani et al, 2008).…”

Section: Structure Characteristics Of Mtsmentioning

confidence: 99%

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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“…According to Maffuci et al (2005), it appears that loggerhead turtles can regulate Se concentrations through homeostatic processes in a balance between metabolic requirements and prevention against toxic effects. Also the presence of Se in tissues reduces Cd toxicity by storing and reallocating these toxic metals and thus, diminishing its potential adverse effect (Siscar et al, 2014). Heavy metals or metalloids, including Pb, As and Cd, have an important physiological role in reactive oxygen species (ROS)-generating reactions (Konigsberg, 2008), and elements such as Se, Zn, Cu or Mn have a protective role in preventing metals toxicity in aquatic organisms due to their association with antioxidant enzymes (Livingstone, 2001), such as glutathione peroxidase and superoxide dismutase.…”

Section: Element Correlationsmentioning

confidence: 99%

Metals and metalloids in whole blood and tissues of Olive Ridley turtles ( Lepidochelys olivacea ) from La Escobilla Beach (Oaxaca, Mexico)

Cortés-Gómez

Fuentes-Mascorro

Romero

2014

Marine Pollution Bulletin

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The role of metallothionein and selenium in metal detoxification in the liver of deep-sea fish from the NW Mediterranean Sea

Cited by 64 publications

References 54 publications

The advantages of deep ocean water for the development of functional fermentation food

The advantages of deep ocean water for the development of functional fermentation food

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Metals and metalloids in whole blood and tissues of Olive Ridley turtles ( Lepidochelys olivacea ) from La Escobilla Beach (Oaxaca, Mexico)

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