The role of metabolic syndrome in heart failure

Perrone‐Filardi, Pasquale; Paolillo, Stefania; Costanzo, Pierluigi; Savarese, Gianluigi; Trimarco, Bruno; Bonow, Robert O.

doi:10.1093/eurheartj/ehv350

Cited by 104 publications

(85 citation statements)

References 72 publications

(73 reference statements)

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“…Therefore, collectively, muscle PGC‐1α reduces the development of an age‐related metabolic syndrome. As the metabolic syndrome is highly predictive for heart disorders and failure (Perrone‐Filardi et al., 2015), it would be interesting to study the effect of exercise combined with modulation of muscle PGC‐1α on the aging heart.…”

Section: Discussionmentioning

confidence: 99%

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

et al. 2017

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SummaryThe age‐related impairment in muscle function results in a drastic decline in motor coordination and mobility in elderly individuals. Regular physical activity is the only efficient intervention to prevent and treat this age‐associated degeneration. However, the mechanisms that underlie the therapeutic effect of exercise in this context remain unclear. We assessed whether endurance exercise training in old age is sufficient to affect muscle and motor function. Moreover, as muscle peroxisome proliferator‐activated receptor γ coactivator 1α (PGC‐1α) is a key regulatory hub in endurance exercise adaptation with decreased expression in old muscle, we studied the involvement of PGC‐1α in the therapeutic effect of exercise in aging. Intriguingly, PGC‐1α muscle‐specific knockout and overexpression, respectively, precipitated and alleviated specific aspects of aging‐related deterioration of muscle function in old mice, while other muscle dysfunctions remained unchanged upon PGC‐1α modulation. Surprisingly, we discovered that muscle PGC‐1α was not only involved in improving muscle endurance and mitochondrial remodeling, but also phenocopied endurance exercise training in advanced age by contributing to maintaining balance and motor coordination in old animals. Our data therefore suggest that the benefits of exercise, even when performed at old age, extend beyond skeletal muscle and are at least in part mediated by PGC‐1α.

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Section: Discussionmentioning

confidence: 99%

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

et al. 2017

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“…The metabolic syndrome additionally comprises abdominal (central) obesity, high blood pressure, insulin resistance, and lipid abnormalities (Perrone-Filardi et al 2015). It is present in 34% of the population, and greatly increases the risk of heart failure (Perrone-Filardi et al 2015).…”

Section: The Role Of Evs In Diabetes and Metabolic Diseasementioning

confidence: 99%

Microvesicles and exosomes: new players in metabolic and cardiovascular disease

Lawson¹,

Vicencio²,

Yellon³

et al. 2016

Journal of Endocrinology

282

241

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The past decade has witnessed an exponential increase in the number of publications referring to extracellular vesicles (EVs). For many years considered to be extracellular debris, EVs are now seen as novel mediators of endocrine signalling via cell-to-cell communication.With the capability of transferring proteins and nucleic acids from one cell to another, they have become an attractive focus of research for different pathological settings and are now regarded as both mediators and biomarkers of disease including cardio-metabolic disease. They also offer therapeutic potential as signalling agents capable of targeting tissues or cells with specific peptides or miRNAs. In this review, we focus on the role that microvesicles (MVs) and exosomes, the two most studied classes of EV, have in diabetes, cardiovascular disease, endothelial dysfunction, coagulopathies, and polycystic ovary syndrome. We also provide an overview of current developments in MV/exosome isolation techniques from plasma and other fluids, comparing different available commercial and non-commercial methods. We describe different techniques for their optical/biochemical characterization and quantitation. We also review the signalling pathways that exosomes and MVs activate in target cells and provide some insight into their use as biomarkers or potential therapeutic agents. In summary, we give an updated focus on the role that these exciting novel nanoparticles offer for the endocrine community.

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“…For example, the adipose tissue, particularly the visceral fat depots, may stimulate central SNS activity through dysregulated adipokine production and secretion. [15][16][17] In addition, experimental studies have recently demonstrated that adipocytes produce and secrete both norepinephrine and epinephrine, 18 therefore, suggesting that the sympathetic fibers within adipose tissue are not the only source of catecholamines. Epicardial adipose tissue (EAT) is the visceral fat depot of the heart and represents a source of several adipocytokines and other bioactive molecules.…”

mentioning

confidence: 99%

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

Parisi

Rengo

Perrone‐Filardi

et al. 2016

Circulation Research

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Rationale: It has been reported that epicardial adipose tissue (EAT) may affect myocardial autonomic function.Objective: The aim of this study was to explore the relationship between EAT and cardiac sympathetic nerve activity in patients with heart failure. Methods and Results:In 110 patients with systolic heart failure, we evaluated the correlation between echocardiographic EAT thickness and cardiac adrenergic nerve activity assessed by Conclusions:This study provides the first evidence of a direct correlation between increased EAT thickness and cardiac sympathetic denervation in heart failure. (Circ Res.

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The role of metabolic syndrome in heart failure

Cited by 104 publications

References 72 publications

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice

Microvesicles and exosomes: new players in metabolic and cardiovascular disease

Increased Epicardial Adipose Tissue Volume Correlates With Cardiac Sympathetic Denervation in Patients With Heart Failure

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