The role of mesenchymal stromal cells in skin wound healing

Xenogeneic mesenchymal stem cell biocurative improves skin wounds healing in diabetic mice by increasing mast cells and the regenerative profile

“…MSCs administered by biocuratives stimulate the immune system, which in turn has a direct impact on healing [ 31 ]. Inflammation is necessary in the first phase of the healing process.…”

“…In diabetic patients, MSCs resolve the inflammation phase of the healing, recognize pro-inflammatory factors such as TNF-α and interferon-γ (IFN-γ), and secrete anti-inflammatory cytokines such as IL-10 and TGF-β, which contribute to the differentiation of M2 macrophages and favor the healing process. MSCs also act in the initiation of the proliferative phase, through the secretion of growth factors, such as VEGF and platelet-derived growth factor (PDGF) that stimulate proliferation of endothelial cells and fibroblasts [ 25 , [29] , [30] , [31] , [32] , [33] , [34] ]. New studies aimed to create biocuratives composed of hydrogel matrices associated with mesenchymal cells have been launched.…”