The role of membrane-bound porphyrin-type compound as endogenous sensitizer in photodynamic damage to yeast plasma membranes

Fraikin, G. Ya.; Strakhovskaya, M. G.; Rubin, A. B.

doi:10.1016/1011-1344(96)07287-9

Cited by 44 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Irradiation with 20-50 J/cm 2 of broadband visible light without the addition of exogenous sensitizers was found to produce oxygendependent lethal effects of plasma membranes and mitochondria of Candida guilliermondii [20]. However in another study [9], the viability of suspensions of C. albicans was not affected by irradiation with 66 J/cm 2 of red laser light (632.8 nm).…”

Section: Porphyrinsmentioning

confidence: 94%

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

Calzavara‐Pinton

Venturini

Sala

2005

Journal of Photochemistry and Photobiology B: Biology

183

119

View full text Add to dashboard Cite

Section: Porphyrinsmentioning

confidence: 94%

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

Calzavara‐Pinton

Venturini

Sala

2005

Journal of Photochemistry and Photobiology B: Biology

183

119

View full text Add to dashboard Cite

“…The biological role of photodynamic reactions mediated by naturally occurring endogenous porphyrins is presently being debated. Irradiation with 20–50 J cm −2 of broadband visible light without the addition of exogenous sensitizers was found to produce oxygen dependent lethal effects of plasma membranes and mitochondria of C. guilliermondii (34). However in another study (35), the viability of suspensions of C. albicans was not affected by irradiation with 66 J cm −2 of red laser light (632.8 nm).…”

Section: Photosensitizersmentioning

confidence: 99%

Photodynamic Antifungal Chemotherapy^†

Calzavara‐Pinton

Rossi

Sala

et al. 2012

Photochem & Photobiology

159

View full text Add to dashboard Cite

The growing resistance against antifungal drugs has renewed the search for alternative treatment modalities, and antimicrobial photodynamic therapy (PDT) seems to be a potential candidate. Preliminary findings have demonstrated that dermatophytes and yeasts can be effectively sensitized in vitro and in vivo by administering photosensitizers (PSs) belonging to four chemical groups: phenothiazine dyes, porphyrins and phthalocyanines, as well as aminolevulinic acid, which, while not a PS in itself, is effectively metabolized into protoporphyrin IX. Besides efficacy, PDT has shown other benefits. First, the sensitizers used are highly selective, i.e., fungi can be killed at combinations of drug and light doses much lower than that needed for a similar effect on keratinocytes. Second, all investigated PSs lack genotoxic and mutagenic activity. Finally, the hazard of selection of drug resistant fungal strains has been rarely reported. We review the studies published to date on antifungal applications of PDT, with special focus on yeast, and aim to raise awareness of this area of research, which has the potential to make a significant impact in future treatment of fungal infections.

show abstract

“…the combined use of photosensitisers and visible light, is considered to be a new potential method for inactivation of microorganisms [1,2,3,4], in the context of the disinfection of water, blood and blood products [5]. A number of photosensitisers are known to be phototoxic towards a variety of Gram-positive bacteria, mycoplasma and yeast [2,6,7]. However, Gram-negative bacteria have not usually been susceptible to photosensitising effects, unless the permeability of their membranes has been artificially increased [8,9].…”

Section: Introductionmentioning

confidence: 99%

Photobiological activity of exogenous and endogenous porphyrin derivatives in Escherichia coli and Enterococcus hirae cells

Gábor

Szocs

Maillard

et al. 2001

Radiation and Environmental Biophysics

View full text Add to dashboard Cite

Photodynamic treatment, the combined application of a photosensitiser and visible light, represents a new and promising approach for the inactivation of microorganisms. The photosensitising potentials of exogenous zinc-phthalocyanine-tetrasulphonate (ZnPsTS), tetraphenylporphyrins (TPPs) and endogenous porphyrin derivatives were tested and compared on Gram-negative and Gram-positive bacteria, Escherichia coli B. and Enterococcus hirae, respectively. The synthesis of endogenous porphyrins was induced by 5-aminolevulinic acid (delta-ALA). The porphyrin- or delta-ALA-treated cells were irradiated with white light. The photosensitising efficiency of endogenous derivatives on both types of bacteria is ZnPcTS < TP(4-OGluOH)3P < TP(4-OGluOH)4P. However, neither exogenous derivatives exhibit appreciable photosensitising activity for disinfection application. ALA-induced photodynamic treatment showed good potential for the inactivation of Escherichia coli cells, but not towards Enterococcus hirae cells. The failure of photosensitisation of the Enterococcus hirae strain selected indicates that apart from the Gram-positive character, other structural elements of the membrane can influence the result of photodynamic treatments.

show abstract

The role of membrane-bound porphyrin-type compound as endogenous sensitizer in photodynamic damage to yeast plasma membranes

Cited by 44 publications

References 18 publications

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

Photodynamic Antifungal Chemotherapy^†

Photobiological activity of exogenous and endogenous porphyrin derivatives in Escherichia coli and Enterococcus hirae cells

Contact Info

Product

Resources

About

The role of membrane-bound porphyrin-type compound as endogenous sensitizer in photodynamic damage to yeast plasma membranes

Cited by 44 publications

References 18 publications

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

A comprehensive overview of photodynamic therapy in the treatment of superficial fungal infections of the skin

Photodynamic Antifungal Chemotherapy†

Photobiological activity of exogenous and endogenous porphyrin derivatives in Escherichia coli and Enterococcus hirae cells

Contact Info

Product

Resources

About

Photodynamic Antifungal Chemotherapy^†